DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS-m and TWN2

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_172913.1	Gene:	TWN2 / 838023	AraportID:	AT1G14610	Length:	1108	Species:	Arabidopsis thaliana

Alignment Length:	1032	Identity:	381/1032 - (36%)
Similarity:	572/1032 - (55%)	Gaps:	122/1032 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 STLKDAANELP-------------------LAAGYQPQPVEN---AYWEREHRQANLPKASASSC 70
            |:.:||:.|.|                   :|..|.|..||.   |:||:    ::|.||.|.|.
plant   106 SSKRDASEENPEDFVDPETPLGERKRLSSQMAKQYSPATVEKSWYAWWEK----SDLFKADAKSS 166

  Fly    71 KRGTYRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIA 135
            | ..:.::||||||||.||:||||.:.::|.|.|.:...||...||||.||||||||||||:.|.
plant   167 K-PPFVIVLPPPNVTGALHIGHALTSAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKIM 230

  Fly   136 ASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERL 200
            ..:..|||::||..|:.|||:||.:.|..|:..||:||..|:|.||.||||||::.||..||.||
plant   231 RDRGMTRHDVGREEFVKEVWKWKNQYGGTILTQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 295

  Fly   201 FEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEA 265
            ::||||.|...:|||...||:||||:||:.::|.|...:.||||:..|.||.:..|||.:
plant   296 YKEGLIYRDIRLVNWDCILRTAISDVEVEYIDIKEKTLLKVPGYEKPVEFGLLTSFAYPL----- 355

  Fly   266 LPDGSVEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFD-ITVDQ 329
              :|.:.|::|:|||.||:|||.|:|:||.|   |:|:::......|||....:|::.| |.||.
plant   356 --EGGLGEVIVATTRVETMLGDTAIAIHPDD---ARYKHLHGKFAVHPFNGRKLPIICDGILVDP 415

  Fly   330 EFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLV-VDAYSEYKGIPRFEARDLIVNRLEEM 393
            .||||.||||||||..|.|:..|||||...:||:.|.: .:..|::.|:|||.||:.:|..|::.
plant   416 NFGTGCVKITPAHDPNDCEVGKRHKLEFINIFTDDGKINTNGGSDFAGMPRFAAREAVVEALQKQ 480

  Fly   394 DLLRQVRSHTMQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSEL---HSGRLQILPPNFETEW 455
            .|.|..:::.|:|.:|||:.||||.||.|||::.|..:.|:||...   .:.:|:.:|..:..||
plant   481 GLYRGAKNNEMRLGLCSRTNDVIEPMIKPQWYVNCSMIGKEALDVAITDENKKLEFVPKQYTAEW 545

  Fly   456 ERWLQDSRDWCISRQLWWGHQVPA-YEVIDSQG-------NSQWVAALDEKTARQKAMRLIGSEE 512
            .|||::.|||||||||||||::|| |..::...       :..||.|..|..||::|.:....::
plant   546 RRWLENIRDWCISRQLWWGHRIPAWYATLEEDQLKEVGAYSDHWVVARTEDDAREEAAQKFLGKK 610

  Fly   513 FTLKRDPDVLDTWFSSSLLPFSTAGWPE--ESYKERYPLDIMQTGHDIIFFWVARMMMLGLKLTG 575
            |.|.||||||||||||.|.|.|..|||:  :.:|..||..:::|||||:|||||||:|:|:||.|
plant   611 FELTRDPDVLDTWFSSGLFPLSVLGWPDVTDDFKAFYPTSVLETGHDILFFWVARMVMMGMKLGG 675

  Fly   576 EAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKAST 640
            |.||.::..:.::.||||||||||:||::.|.:|:.|.:||    ||.:..|.|.:.|.|:..:.
plant   676 EVPFSKVYFHPMIRDAHGRKMSKSLGNVIDPLEVINGVTLE----GLHKRLEEGNLDPKEVIVAK 736

  Fly   641 IGMTQMFPNGIQECGTDALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLG 705
            .|..:.|||||.|||||||||.|:|:..:|..|:.|:......:.:.||:|.|:||.:   ..||
plant   737 EGQVKDFPNGIPECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAM---MKLG 798

  Fly   706 ISLHQFETLEGVNLGLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTK 770
            ......:||....:....:||:..|.:.:|....|...:.|..|...:..::....||.|:|..|
plant   799 DGYTPPQTLSPETMPFSCQWILSVLNKAISKTVVSLDAFEFSDAANTIYAWWQYQFCDVYIEAIK 863

  Fly   771 PAIGNRS---ADAYIHV-GTLTACLSWGLQAMAPYAPFVASELLQHVPL--NIELKLS----DY- 824
            |.....:   |....|. ..|...|..||:.:.|:.|||..||.|.:|.  :.|.|.|    ||
plant   864 PYFAGDNPTFASERAHAQHALWISLETGLRLLHPFMPFVTEELWQRLPAPKDTERKASIMICDYP 928

  Fly   825 ------KDEKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFA--QNTDSEGVLRRHLPQIK 881
                  .:||:|.|::.::.....:|.::: ..:.|:.:.:|..||  :|..:..:::.|..:|:
plant   929 SAIENWSNEKVESEMDTVLATVKCMRALRA-GLLEKQKNERLPAFALCENNVTSEIVKSHELEIR 992

  Fly   882 VLSRCEDVE--------------LELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPEKRD 932
            .|:....:|              :|..:|:.|:     |....||:.:
plant   993 TLANLSSLEVVSKGQHAAPPGSSVETVNENLKV-----YLEVDGAINT----------------- 1035

  Fly   933 EMQKANAKKLKKLVTELQRYRMRLDN----EAFQLMADKKVKSHFENKVKELEAEIN 985
               :|..:|::..:.|||:.:.:|..    ..::......:|....||:.::..|.:
plant  1036 ---EAEQEKIRNKIGELQKQKEKLQKMMSVSTYEEKVPANIKEDNANKLAKILQEFD 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	381/1032 (37%)
		ValRS_core	73..675	CDD:185677	289/616 (47%)
		tRNA-synt_1_2	268..391	CDD:290334	56/124 (45%)
		Anticodon_Ia_Val	675..812	CDD:153416	36/140 (26%)
TWN2	NP_172913.1	PLN02381	41..1106	CDD:215214	381/1032 (37%)
		ValRS_core	168..771	CDD:185677	289/616 (47%)
		tRNA-synt_1_2	351..477	CDD:290334	59/135 (44%)
		Anticodon_Ia_Val	771..910	CDD:153416	37/141 (26%)
		Val_tRNA-synt_C	1034..1099	CDD:287436	10/76 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830