Protein Alignment ValRS-m and VARS1

DIOPT Version :10

• Sequence 1: NP_648268.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: XP_005249419.1
• Gene: VARS1 / 7407
• HGNCID: 12651
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 1024
• Identity: 402/1024 - (39%)
• Similarity: 562/1024 - (54%)
• Gaps: 115/1024 - (11%)

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE---HRQANLPKASASSCKRGTYRMLLPPPNVTGNLH 89
            ||.:.  |:...|.|:.||.|   :||::   ..:...|..||:: .||.:.|.:|||||||:||
Human   291 KDVSG--PMPDSYSPRYVEAAWYPWWEQQGFFKPEYGRPNVSAAN-PRGVFMMCIPPPNVTGSLH 352

  Fly    90 LGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEV 154
            |||||...:||.:.|.....|....|.||.||||||||||||:.:...|..:||:|||.|||.||
Human   353 LGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEV 417

  Fly   155 WRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTAL 219
            |:||.|||..|...|::||..|:|.|..||||.:.:.||..||.||.|||:|.|...:|||...|
Human   418 WKWKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCTL 482

  Fly   220 RSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETI 284
            .|||||||||..|:|....:|||||..||.||.:..|||.|...:     |.||:||:|||.||:
Human   483 NSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSD-----SDEEVVVATTRIETM 542

  Fly   285 LGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFEL 349
            ||||||||||.|.||...:..:.:   |||...::|:|||..||.:|||||||||||||:.|:|:
Human   543 LGDVAVAVHPKDTRYQHLKGKNVI---HPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQNDYEV 604

  Fly   350 ATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
            ..||.||...:....|.:::....:.|:||||||..::..|:|..|.|.:..:.|.:|:|:||||
Human   605 GQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSKD 669

  Fly   415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPA 479
            |:|.::.|||:::|.::|:.|.:.:..|.|:|||...:..|..|:.:.|:|||||||||||::||
Human   670 VVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWCISRQLWWGHRIPA 734

  Fly   480 YEVI----------DSQGNSQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLP 532
            |.|.          |..|. .||:..:|..||:||.:..|  .::.:|::|.|||||||||.|.|
Human   735 YFVTVSDPAVPPGEDPDGR-YWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFP 798

  Fly   533 FSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRK 595
            .|..|||.:|  ....||..:::|||||:|||||||:||||||||..||:.:.|:.||.||||||
Human   799 LSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRK 863

  Fly   596 MSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALR 660
            ||||:||::.|..|:.|.||:    ||........:.|||::.:..|....||.||.||||||||
Human   864 MSKSLGNVIDPLDVIYGISLQ----GLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALR 924

  Fly   661 FTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLE-GVNLGLWDR 724
            |.|.::..:...|:.|||.....:.|.||:|.|.:|.|   :|||.......|.: |.:..|.||
Human   925 FGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFAL---RGLGKGFVPSPTSQPGGHESLVDR 986

  Fly   725 WIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-GNRSADAYIHVGTLT 788
            ||..||.|.:.:.:|.:..|:|...|.|..:|:...|||.|||..||.: |.....|.....||.
Human   987 WIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLY 1051

  Fly   789 ACLSWGLQAMAPYAPFVASELLQHVPLNI-------------ELKLSDYKDEKLEEEVNEIVNIC 840
            .||..||:.::|:.|||..||.|.:|..:             |.....:||.:.|..:...::|.
Human  1052 TCLDVGLRLLSPFMPFVTEELFQRLPRRMPQAPPSLCVTPYPEPSECSWKDPEAEAALELALSIT 1116

  Fly   841 HNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDE-----SSKI 900
            ..||.:::...:: |..|                             |..||:.||     :|.:
Human  1117 RAVRSLRADYNLT-RIRP-----------------------------DCFLEVADEATGALASAV 1151

  Fly   901 SKQLSYFSTAGAL---------------------CSFGLKLSDGLDLTPEKRDEMQKANAKKLKK 944
            |..:...::||.:                     ||..|:|...:|  |.:  |:.|..||:: :
Human  1152 SGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVD--PAR--ELGKLQAKRV-E 1211

  Fly   945 LVTELQRYRMRLDNEAFQLMADKKVKSHFENKVKELEAEINSLTRLAVL 993
            ...:.||.|.|.....:.:....:|:...|.|:::.|||:..:.....|
Human  1212 AQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIAL 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_648268.1	PTZ00419	23..989	CDD:240411	401/1018 (39%)
VARS1	XP_005249419.1	GST_C_ValRS_N	92..213	CDD:198327
		PTZ00419	283..1265	CDD:240411	402/1024 (39%)