Protein Alignment ValRS-m and Vars2

DIOPT Version :10

• Sequence 1: NP_648268.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_780346.3
• Gene: Vars2 / 68915
• MGIID: 1916165
• Length: 1060
• Species: Mus musculus
• Alignment Length: 999
• Identity: 383/999 - (38%)
• Similarity: 536/999 - (53%)
• Gaps: 86/999 - (8%)

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE-----HRQANLPKASASSCKRGTYRMLLPPPNVTGN 87
            ||.:..||.|  |.||.||.|   :|.||     ..||.||:|:..     |:.|.:|||||||:
Mouse    94 KDVSGPLPPA--YSPQYVEAAWYQWWVREGFFKPEYQARLPQATGE-----TFSMCIPPPNVTGS 151

  Fly    88 LHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLD 152
            ||:||||...:||.:.|.....|.:|.|:||:||||||||.:||:.:...|...||||.|..||.
Mouse   152 LHIGHALTVAIQDALVRWHRMRGDRVLWIPGSDHAGIATQAMVEKQLWKEQRVRRHELSREDFLR 216

  Fly   153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCT 217
            .||:||.|||..|.:.|..||..|:|.||.||||...:.||..||.||:..||:.|...:|||..
Mouse   217 AVWQWKHEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYNSGLLYRNRQLVNWSC 281

  Fly   218 ALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPE 282
            .||||||||||:|..:.....:.:||....|.||.:...|: .||||  ||   .||||.|||||
Mouse   282 TLRSAISDIEVESRPLPGRTVLQLPGCPTPVSFGLLASVAF-PVDGE--PD---TEIVVGTTRPE 340

  Fly   283 TILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDF 347
            |:.|||||||||.||||.   ::...:|:||.....:||:.|.||....||||||:||||...|.
Mouse   341 TLPGDVAVAVHPDDPRYT---HLHGRQLRHPLTGQLLPLITDTTVQPHVGTGAVKVTPAHSPIDA 402

  Fly   348 ELATRHKLEPRQVFTETGLVVDAYSEY-KGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSR 411
            |:.|||.|.|..|..|.|.:.....:: :|:.||.||:.|:..|.|..|.|.::.|.|.||||||
Mouse   403 EIGTRHGLTPLSVIAEDGTMTSLCGDWLQGLHRFVAREKIMCTLREQGLFRGLQEHPMVLPICSR 467

  Fly   412 SKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQ 476
            |.||:||::..|||::|:::...|...:.||.|::.|...:..|:.|.....|||:|||||||||
Mouse   468 SGDVVEYLLKSQWFVRCQEMGDLAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQ 532

  Fly   477 VPAYEVIDSQGNSQ----WVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFST 535
            :|||.||.......    ||....|..||..|.:..|  ..|.||:||||||||||||:|.|||.
Mouse   533 IPAYRVIGENAEDDRKECWVVGRSEAEARAVAAKRTGRPEAELTLERDPDVLDTWFSSALFPFSA 597

  Fly   536 AGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSK 598
            .|||.|:  ....|||.:::||.|::.|||.||:|||.:|||:.||.::||:.:|.|..||||||
Mouse   598 LGWPRETPDLAHFYPLTLLETGSDLLMFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSK 662

  Fly   599 SIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFTL 663
            |:||::.|:.::.|..|:.|:|.|..    |.:.|.||..:.....:.||.||.|||||||||.|
Mouse   663 SLGNVLDPRDIISGQELQVLQAKLRD----GNLDPGELAVAAAAQKKDFPYGIPECGTDALRFAL 723

  Fly   664 MSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGVNLGLWDRWIVG 728
            .||.|....:...|:.....:.|.||:|.|:||.|   :.||.:.......|.......|.||:.
Mouse   724 CSHGILGGDLHLSVSEVLNYRHFCNKLWNALRFVL---RALGDNFVPQPAEEVTPSSPMDAWILS 785

  Fly   729 RLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRSADAYIHVG---TLTAC 790
            |||...|.|.:.:.:....|.|..|..|:...|||.|||..||.:.:.....    |   .|.:|
Mouse   786 RLAFAASECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVLSSVPRPP----GPPQVLFSC 846

  Fly   791 LSWGLQAMAPYAPFVASELLQHV------PLNIELKLSDY---------KDEKLEEEVNEIVNIC 840
            ...||:.:||..||:|.||.|.:      ||...:.::.|         :..:||...:.:..:.
Mouse   847 ADVGLRLLAPLMPFLAEELWQRLPPRPGGPLAPSICVAPYPSTRSLEFWRQPELERCFSRVQEVV 911

  Fly   841 HNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLS 905
            ..:|.:::..:::|. .||:.|...:...:|:::..|..:.:||.|..|.
Mouse   912 QALRALRATYQLTKA-RPQVLLQCSDPGEQGLVQPFLEPLGILSHCGAVG--------------- 960

  Fly   906 YFSTAGALCSFG---LKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQRYRMRLDNEAFQLMADK 967
             |.:.||....|   ..|.|.:.:..|.:..:...:  :|.:|....|:.:.:||:...:.|::.
Mouse   961 -FLSPGAAAPSGWALTPLGDTMKIYMELQGLVDPQS--QLPRLTARRQKLQKQLDDLLNRTMSEG 1022

  Fly   968 KVKSHFENKVKELEAEINSLTRLA 991
            ..:.  :.::..|..|::.|.:.|
Mouse  1023 LAER--QQRISSLHLELSKLDQAA 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_648268.1	PTZ00419	23..989	CDD:240411	382/995 (38%)
Vars2	NP_780346.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..50
		PTZ00419	90..1018	CDD:240411	378/969 (39%)
		'HIGH' region	146..156		7/9 (78%)
		'KMSKS' region	659..663		3/3 (100%)