Protein Alignment ValRS-m and VARS2

DIOPT Version :9

• Sequence 1: NP_001286988.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_001161206.1
• Gene: VARS2 / 57176
• HGNCID: 21642
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 1000
• Identity: 381/1000 - (38%)
• Similarity: 550/1000 - (55%)
• Gaps: 87/1000 - (8%)

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE-----HRQANLPKASASSCKRGTYRMLLPPPNVTGN 87
            ||.:..||.|  |.|:.||.|   :|.||     ..||.||:|:..     |:.|.:|||||||:
Human   124 KDVSGPLPPA--YSPRYVEAAWYPWWVREGFFKPEYQARLPQATGE-----TFSMCIPPPNVTGS 181

  Fly    88 LHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLD 152
            ||:||||...:||.:.|.....|.||.||||:||||||||.|||:.:...:...||||.|.|||.
Human   182 LHIGHALTVAIQDALVRWHRMRGDQVLWVPGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLR 246

  Fly   153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCT 217
            |||:||..||..|.:.||.||..|:|.||.||||...:.||..||.||::.||:.|.:.:|||..
Human   247 EVWQWKEAKGGEICEQLRALGASLDWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSC 311

  Fly   218 ALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPE 282
            |||||||||||::..:....::.:||....|.||.::..|: .||||  ||.   |:||.|||||
Human   312 ALRSAISDIEVENRPLPGHTQLRLPGCPTPVSFGLLFSVAF-PVDGE--PDA---EVVVGTTRPE 370

  Fly   283 TILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDF 347
            |:.|||||||||.|.||.   ::...:|:||.....:||:.|..|....||||||:||||...|.
Human   371 TLPGDVAVAVHPDDSRYT---HLHGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADA 432

  Fly   348 ELATRHKLEPRQVFTETGLVVDAYSEY-KGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSR 411
            |:..||.|.|..|..|.|.:.....:: :|:.||.||:.|::.|.|..|.|.:::|.|.||||||
Human   433 EMGARHGLSPLNVIAEDGTMTSLCGDWLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSR 497

  Fly   412 SKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQ 476
            |.|||||::..|||::|:::...|...:.||.|::.|...:..|:.|.....|||:|||||||||
Human   498 SGDVIEYLLKNQWFVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQ 562

  Fly   477 VPAYEVID--SQGNSQ-WVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFSTA 536
            :|||.|::  :||... ||....|..||:.|..|.|  ..|.||:||||||||||||:|.|||..
Human   563 IPAYLVVEDHAQGEEDCWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSAL 627

  Fly   537 GWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSKS 599
            |||:|:  ....|||.:::||.|::.|||.||:|||.:|||:.||.::||:.:|.|..|||||||
Human   628 GWPQETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMSKS 692

  Fly   600 IGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFTLM 664
            :||::.|:.::.|..::.    |::...:|.:.|:||........:.||:||.|||||||||||.
Human   693 LGNVLDPRDIISGVEMQV----LQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRFTLC 753

  Fly   665 SHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGVNLGLWDRWIVGR 729
            ||.:::..:...|:...:.:.|.||:|.|:||.|.:   ||.........|.......|.||:.|
Human   754 SHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNA---LGEKFVPQPAEELSPSSPMDAWILSR 815

  Fly   730 LAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRSADAYIHVG---TLTACL 791
            ||.....|.:.:......|.|.||..|:...|||.|||..||.:.:....    :|   .|.:|.
Human   816 LALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRP----LGPPQVLFSCA 876

  Fly   792 SWGLQAMAPYAPFVASELLQHVP----------LNI-----ELKLSDYKDEKLEEEVNEIVNICH 841
            ..||:.:||..||:|.||.|.:|          :::     ...|..::..:||...:.:..:..
Human   877 DLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSACSLEHWRQPELERRFSRVQEVVQ 941

  Fly   842 NVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDESSKISKQLSY 906
            .:|.:::..:::|. .|::.|.:.....:|:....|..:..|..|..|.|
Human   942 VLRALRATYQLTKA-RPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGL--------------- 990

  Fly   907 FSTAGALCSFG---LKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQRYRM--RLDNEAFQLMAD 966
             ...||....|   ..|||    |.:...|:|.....:::..:...:||::  :||:...:..::
Human   991 -LPPGAAAPSGWAQAPLSD----TAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSE 1050

  Fly   967 KKVKSHFENKVKELEAEINSLTRLA 991
            .:..:..:.|:..|:.|::.|.:.|
Human  1051 GEAGTQRQQKLSSLQLELSKLDKAA 1075

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	380/996 (38%)
		ValRS_core	73..675	CDD:185677	286/609 (47%)
		tRNA-synt_1_2	268..391	CDD:290334	54/123 (44%)
		Anticodon_Ia_Val	675..812	CDD:153416	44/139 (32%)
VARS2	NP_001161206.1	tRNA-synt_1g	116..1081	CDD:330949	380/999 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930