DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS-m and Vars2

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_998728.1	Gene:	Vars2 / 309596	RGDID:	1303122	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	1004	Identity:	377/1004 - (37%)
Similarity:	533/1004 - (53%)	Gaps:	91/1004 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE-----HRQANLPKASASSCKRGTYRMLLPPPNVTGN 87
            ||.:..||.|  |.||.||.|   :|.||     ..||.||:|:..     |:.|.:|||||||:
  Rat    94 KDVSGPLPPA--YSPQYVEAAWYQWWVREGFFKPEYQARLPQATGE-----TFSMCIPPPNVTGS 151

  Fly    88 LHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLD 152
            ||:||||...:||...|.....|.:|.|:||:||||||||.|||:.:...:...||||.|..||.
  Rat   152 LHIGHALTVAIQDAFVRWHRMRGDRVLWIPGSDHAGIATQAVVEKQLWRERRVRRHELSREDFLR 216

  Fly   153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCT 217
            .||:||.|||..|.:.|..||..|:|.||.||||...:.||..||.||::.||:.|...:|||..
  Rat   217 AVWQWKQEKGGEIYEQLCALGASLDWDRECFTMDAGSSAAVTEAFVRLYDLGLLYRNRQLVNWSC 281

  Fly   218 ALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPE 282
            .||||||||||:|..:.....:.:||....|.||.:...|: .|||:   .|:  ||||.|||||
  Rat   282 TLRSAISDIEVESRPLPGRTVLRLPGCPIPVSFGLLVSIAF-PVDGD---PGT--EIVVGTTRPE 340

  Fly   283 TILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDF 347
            |:.|||||||||.||||.   ::...:|:||.....:||:.|.||....||||||:||||...|.
  Rat   341 TLPGDVAVAVHPDDPRYT---HLHGRQLRHPLTGQHLPLITDTTVQPHVGTGAVKVTPAHSPADA 402

  Fly   348 ELATRHKLEPRQVFTETGLVVDAYSEY-KGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSR 411
            |:.|||.|.|..|..|.|.:.....:: :|:.||.||:.|:..|.|..|.|.::.|.|.||||||
  Rat   403 EMGTRHGLTPLSVIAEDGTMTSLCGDWLQGLHRFVAREKIMCTLRERGLFRGLQEHPMVLPICSR 467

  Fly   412 SKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQ 476
            |.||:||::..|||::|:::...|...:.||.|::.|...:..|:.|.....|||:|||||||||
  Rat   468 SGDVVEYLLKSQWFVRCQEMGDRAAKAVESGALELWPSFHQKSWQHWFAHIGDWCVSRQLWWGHQ 532

  Fly   477 VPAYEV----IDSQGNSQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFST 535
            :|||.|    .:......||....|..||..|.:..|  ..|.||:||||||||||||:|.|||.
  Rat   533 IPAYRVGGEKAEDDREECWVVGRSEAEARAAAAKQTGRPEAELTLERDPDVLDTWFSSALFPFSA 597

  Fly   536 AGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSK 598
            .|||:|:  ....|||.:::||.|::.|||.||:|||.:|||:.||.::||:.:|.|..||||||
  Rat   598 LGWPQETPDLARFYPLTLLETGSDLLTFWVGRMVMLGTQLTGQLPFSKVLLHSMVRDRQGRKMSK 662

  Fly   599 SIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFTL 663
            |:||::.|:.::.|..|:.|:|.|..    |.:...||..:.....:.||.||.|||||||||.|
  Rat   663 SLGNVLDPRDIISGQELQVLQAKLRD----GNLDQGELAVAAAAQKKDFPYGIPECGTDALRFAL 723

  Fly   664 MSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGVNLGLWDRWIVG 728
            .||.|....:...|:.....:.|.||:|.|:||.|   :.||.........:.......|.||:.
  Rat   724 CSHGILGGDLHLSVSEVLNYRHFCNKLWNALRFIL---RALGDDFVPQPAEKVTPSSPMDAWILS 785

  Fly   729 RLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAIGNRSADAYIHVG---TLTAC 790
            |||...:.|.:.:.:....|.|..|..|:...|||.|||..||.:    :.|....|   .|.:|
  Rat   786 RLAFAANECERGFLSRELSLVTHTLYHFWLHNLCDVYLEAVKPVL----SSAPCPPGPPQVLFSC 846

  Fly   791 LSWGLQAMAPYAPFVASELLQHVPLN--------------------IELKLSDYKDEKLEEEVNE 835
            ...||:.:||..||:|.||.|.:|..                    :......::..:||...:.
  Rat   847 ADVGLRLLAPLMPFLAEELWQRLPPRQGGSMAPSICVAPYPSGHSLVSRGQESWRQPELEHCFSR 911

  Fly   836 IVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDESSKI 900
            :..|...:|.:::..::: |..|.:.|.:.:...:|:::..|..:.|||.|..|.
  Rat   912 VQEIVQALRALRATYQLT-RARPHVLLQSSDPGEQGLVQPFLEPLGVLSHCGAVG---------- 965

  Fly   901 SKQLSYFSTAGALCSFG---LKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQRYRMRLDNEAFQ 962
                  |...||....|   ..|.|.:.:..|.:..:...:  :|.:|....|:.:.:||:...:
  Rat   966 ------FLPPGAAAPSGWALAPLGDTIKIYMELQGLVDPQS--QLPRLAARRQKLQKQLDDLLNR 1022

  Fly   963 LMADKKVKSHFENKVKELEAEINSLTRLA 991
            .::|...:.  :.::..|:.|::.|.:.|
  Rat  1023 TVSDGPAER--QQRISSLQLELSKLDQAA 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	376/1000 (38%)
		ValRS_core	73..675	CDD:185677	282/610 (46%)
		tRNA-synt_1_2	268..391	CDD:290334	58/123 (47%)
		Anticodon_Ia_Val	675..812	CDD:153416	43/139 (31%)
Vars2	NP_998728.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..52
		PTZ00419	86..1055	CDD:240411	377/1004 (38%)
		ValRS_core	137..735	CDD:185677	282/615 (46%)
		'HIGH' region	146..156		7/9 (78%)
		'KMSKS' region	659..663		3/3 (100%)
		Anticodon_Ia_Val	735..869	CDD:153416	44/140 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930