Protein Alignment ValRS-m and Vars1

DIOPT Version :10

• Sequence 1: NP_648268.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_445744.1
• Gene: Vars1 / 25009
• RGDID: 3950
• Length: 1264
• Species: Rattus norvegicus
• Alignment Length: 1029
• Identity: 409/1029 - (39%)
• Similarity: 562/1029 - (54%)
• Gaps: 125/1029 - (12%)

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE---HRQANLPKASASSCKRGTYRMLLPPPNVTGNLH 89
            ||.:..:|  ..|.||.||.|   :|||:   ..:...|..||.: .||.:.|.:|||||||:||
  Rat   290 KDVSGTMP--DSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPN-PRGVFMMCIPPPNVTGSLH 351

  Fly    90 LGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEV 154
            |||||...:||.:.|.....|....|.||.||||||||||||:.:...:...||:|||.|||.||
  Rat   352 LGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLQEV 416

  Fly   155 WRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTAL 219
            |:||||||..|...|::||..|:|.|..||||.:.:..|..||.||.|||:|.|...:|||...|
  Rat   417 WKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTL 481

  Fly   220 RSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETI 284
            .|||||||||..|:|....:|||||..||.||.:..|||.|...:     |.||:||:|||.||:
  Rat   482 NSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSD-----SDEEVVVATTRIETM 541

  Fly   285 LGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFEL 349
            ||||||||||.|||   |:::....:.|||...::|:|||..||.||||||||||||||:.|:|:
  Rat   542 LGDVAVAVHPKDPR---YQHLKGKSVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEV 603

  Fly   350 ATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
            ..||:||...:....|.:|:....:.|:||||||..::..|:|..|.|.::.:.|.:|:|:||||
  Rat   604 GQRHRLEAISIMDSKGALVNVPPPFLGLPRFEARKAVLAALKEQGLFRGIKDNPMVVPLCNRSKD 668

  Fly   415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPA 479
            |:|.::.|||:::|.::|:.|.:.:..|.|:|||...:..|..|:.:.|||||||||||||::||
  Rat   669 VVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPA 733

  Fly   480 YEVI----------DSQGNSQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLP 532
            |.:.          |..|. .||:...|..||:||.|..|  .::.:|::|.|||||||||.|.|
  Rat   734 YFITVHDPAVPPGEDPDGR-YWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFP 797

  Fly   533 FSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRK 595
            ||..|||.:|  ....||..:::|||||:|||||||:|||||||.:.||:.:.|:.||.||||||
  Rat   798 FSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTEKLPFREVYLHAIVRDAHGRK 862

  Fly   596 MSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALR 660
            ||||:||::.|..|:.|.||:    ||........:.|||::.:..|....||.||.||||||||
  Rat   863 MSKSLGNVIDPLDVIHGVSLQ----GLHDQLLNSNLDPSEVEKAKEGQRADFPAGIPECGTDALR 923

  Fly   661 FTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETL--EGVNLGLWD 723
            |.|.::..:...|:.|||.....:.|.||:|.|.:|.|   :|||.......|.  || :..|.|
  Rat   924 FGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFAL---RGLGKGFVPSPTSKPEG-HESLVD 984

  Fly   724 RWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-GNRSADAYIHVGTL 787
            |||..||||.:.:.::.:..|:|...|.|..:|:...|||.|||..||.: |.....|.....||
  Rat   985 RWIRSRLAEAVRLSNEGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAADCARQTL 1049

  Fly   788 TACLSWGLQAMAPYAPFVASELLQHVPLNI-------------ELKLSDYKDEKLEEEVNEIVNI 839
            ..||..||:.::|:.|||..||.|.:|...             |.....:||.:.|..:...::|
  Rat  1050 YTCLDVGLRLLSPFMPFVTEELFQRLPRRTPNAPASLCVTPYPEPSECSWKDPEAEAALELALSI 1114

  Fly   840 CHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDE-----SSK 899
            ...||.:::...:: |..|                             |..||:.||     :|.
  Rat  1115 TRAVRSLRADYNLT-RTRP-----------------------------DCFLEVADEATGALASA 1149

  Fly   900 ISKQLSYFSTAGAL---------------------CSFGLKLSDGLDLTPEKRDEMQKANAKKLK 943
            :|..:...::||.:                     ||..|:|...:|  |.:  |:.|..||:
  Rat  1150 VSAYVQTLASAGVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVD--PAR--ELGKLQAKR-- 1208

  Fly   944 KLVTELQRYRMRLDN----EAFQLMADKKVKSHFENKVKELEAEINSLTRLAVL 993
               :|.||...||..    ..:......:|:...|.|:::.|||:..:.....|
  Rat  1209 ---SEAQRQAQRLQERRAASGYSAKVPLEVQEADEVKLQQTEAELRKVDEAIAL 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_648268.1	PTZ00419	23..989	CDD:240411	408/1023 (40%)
Vars1	NP_445744.1	GST_C_family	92..213	CDD:470672
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..296		2/5 (40%)
		PTZ00419	282..1264	CDD:240411	409/1029 (40%)
		'HIGH' region	344..354		8/9 (89%)
		'KMSKS' region	862..866		3/3 (100%)