Protein Alignment ValRS-m and Vars1

DIOPT Version :10

• Sequence 1: NP_648268.1
• Gene: ValRS-m / 39023
• FlyBaseID: FBgn0035942
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_035820.3
• Gene: Vars1 / 22321
• MGIID: 90675
• Length: 1263
• Species: Mus musculus
• Alignment Length: 1029
• Identity: 409/1029 - (39%)
• Similarity: 564/1029 - (54%)
• Gaps: 125/1029 - (12%)

  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE---HRQANLPKASASSCKRGTYRMLLPPPNVTGNLH 89
            ||.:..:|  ..|.||.||.|   :|||:   ..:...|..||.: .||.:.|.:|||||||:||
Mouse   289 KDVSGAMP--DSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPN-PRGVFMMCIPPPNVTGSLH 350

  Fly    90 LGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEV 154
            |||||...:||.:.|.....|....|.||.||||||||||||:.:...:...||:|||.|||:||
Mouse   351 LGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEV 415

  Fly   155 WRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTAL 219
            |:||||||..|...|::||..|:|.|..||||.:.:..|..||.||.|||:|.|...:|||...|
Mouse   416 WKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTL 480

  Fly   220 RSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETI 284
            .|||||||||..|:|....:.||||..||.||.:..|||.|...:     |.||:||:|||.||:
Mouse   481 NSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSD-----SDEEVVVATTRIETM 540

  Fly   285 LGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFEL 349
            ||||||||||.|||   |:::....:.|||...::|:|||..||.||||||||||||||:.|:|:
Mouse   541 LGDVAVAVHPKDPR---YQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEV 602

  Fly   350 ATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
            ..||:||...:....|.:::....:.|:||||||..::..|:|..|.|.|:.:.|.:|:|:||||
Mouse   603 GQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKD 667

  Fly   415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPA 479
            |:|.::.|||:::|.::|:.|.:.:..|.|:|||...:..|..|:.:.|||||||||||||::||
Mouse   668 VVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPA 732

  Fly   480 YEVI----------DSQGNSQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLP 532
            |.:.          |..|. .||:...|..||:||.|..|  .::.:|::|.|||||||||.|.|
Mouse   733 YFITVHDPAVPPGEDPDGR-YWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFP 796

  Fly   533 FSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRK 595
            ||..|||.:|  ....||..:::|||||:|||||||:||||||||:.||:.:.|:.||.||||||
Mouse   797 FSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRK 861

  Fly   596 MSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALR 660
            ||||:||::.|..|:.|.||:.|...|..|    .:.|||::.:..|....||.||.||||||||
Mouse   862 MSKSLGNVIDPLDVIHGVSLQGLYDQLLNS----NLDPSEVEKAKEGQKADFPAGIPECGTDALR 922

  Fly   661 FTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETL--EGVNLGLWD 723
            |.|.::..:...|:.|||.....:.|.||:|.|.:|.|   :|||.......|.  || :..|.|
Mouse   923 FGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFAL---RGLGKGFVPSATSKPEG-HESLVD 983

  Fly   724 RWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-GNRSADAYIHVGTL 787
            |||..||.|.:.:.::.:..|:|...|.|..:|:...|||.|||..||.: |.....|.....||
Mouse   984 RWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTL 1048

  Fly   788 TACLSWGLQAMAPYAPFVASELLQHVPLNI-------------ELKLSDYKDEKLEEEVNEIVNI 839
            ..||..||:.::|:.|||..||.|.:|...             |.....:||.:.|..:...::|
Mouse  1049 YTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSECSWKDPEAEAALELALSI 1113

  Fly   840 CHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDE-----SSK 899
            ...||.:::...:: |..|                             |..||:.||     :|.
Mouse  1114 TRAVRSLRADYNLT-RTRP-----------------------------DCFLEVADEATGALASA 1148

  Fly   900 ISKQLSYFSTAGAL---------------------CSFGLKLSDGLDLTPEKRDEMQKANAKKLK 943
            :|..:...::||.:                     ||..|:|...:|  |.:  |:.|..||:
Mouse  1149 VSGYVQALASAGVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVD--PAR--ELGKLQAKR-- 1207

  Fly   944 KLVTELQRYRMRLDN----EAFQLMADKKVKSHFENKVKELEAEINSLTRLAVL 993
               :|.||...||..    .::......:|:...|.|:::.|||:..:.....|
Mouse  1208 ---SEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEAELRKVDEAIAL 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_648268.1	PTZ00419	23..989	CDD:240411	408/1023 (40%)
Vars1	NP_035820.3	GST_C_family	92..213	CDD:470672
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..294		2/4 (50%)
		PTZ00419	281..1263	CDD:240411	409/1029 (40%)
		'HIGH' region	343..353		8/9 (89%)
		'KMSKS' region	861..865		3/3 (100%)