DRSC/TRiP Functional Genomics Resources

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Protein Alignment ValRS-m and Vars

DIOPT Version :9

Sequence 1:NP_001286988.1 Gene:ValRS-m / 39023 FlyBaseID:FBgn0035942 Length:994 Species:Drosophila melanogaster
Sequence 2:NP_035820.3 Gene:Vars / 22321 MGIID:90675 Length:1263 Species:Mus musculus


Alignment Length:1029 Identity:409/1029 - (39%)
Similarity:564/1029 - (54%) Gaps:125/1029 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 KDAANELPLAAGYQPQPVENA---YWERE---HRQANLPKASASSCKRGTYRMLLPPPNVTGNLH 89
            ||.:..:|  ..|.||.||.|   :|||:   ..:...|..||.: .||.:.|.:|||||||:||
Mouse   289 KDVSGAMP--DSYSPQYVEAAWYPWWERQGFFKPEYGRPSVSAPN-PRGVFMMCIPPPNVTGSLH 350

  Fly    90 LGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEV 154
            |||||...:||.:.|.....|....|.||.||||||||||||:.:...:...||:|||.|||:||
Mouse   351 LGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEV 415

  Fly   155 WRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTAL 219
            |:||||||..|...|::||..|:|.|..||||.:.:..|..||.||.|||:|.|...:|||...|
Mouse   416 WKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTL 480

  Fly   220 RSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETI 284
            .|||||||||..|:|....:.||||..||.||.:..|||.|...:     |.||:||:|||.||:
Mouse   481 NSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSD-----SDEEVVVATTRIETM 540

  Fly   285 LGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFEL 349
            ||||||||||.|||   |:::....:.|||...::|:|||..||.||||||||||||||:.|:|:
Mouse   541 LGDVAVAVHPKDPR---YQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEV 602

  Fly   350 ATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
            ..||:||...:....|.:::....:.|:||||||..::..|:|..|.|.|:.:.|.:|:|:||||
Mouse   603 GQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKD 667

  Fly   415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPA 479
            |:|.::.|||:::|.::|:.|.:.:..|.|:|||...:..|..|:.:.|||||||||||||::||
Mouse   668 VVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPA 732

  Fly   480 YEVI----------DSQGNSQWVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLP 532
            |.:.          |..|. .||:...|..||:||.|..|  .::.:|::|.|||||||||.|.|
Mouse   733 YFITVHDPAVPPGEDPDGR-YWVSGRTEAEAREKAAREFGVSPDKISLQQDEDVLDTWFSSGLFP 796

  Fly   533 FSTAGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRK 595
            ||..|||.:|  ....||..:::|||||:|||||||:||||||||:.||:.:.|:.||.||||||
Mouse   797 FSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRK 861

  Fly   596 MSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALR 660
            ||||:||::.|..|:.|.||:.|...|..|    .:.|||::.:..|....||.||.||||||||
Mouse   862 MSKSLGNVIDPLDVIHGVSLQGLYDQLLNS----NLDPSEVEKAKEGQKADFPAGIPECGTDALR 922

  Fly   661 FTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETL--EGVNLGLWD 723
            |.|.::..:...|:.|||.....:.|.||:|.|.:|.|   :|||.......|.  || :..|.|
Mouse   923 FGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFAL---RGLGKGFVPSATSKPEG-HESLVD 983

  Fly   724 RWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-GNRSADAYIHVGTL 787
            |||..||.|.:.:.::.:..|:|...|.|..:|:...|||.|||..||.: |.....|.....||
Mouse   984 RWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTL 1048

  Fly   788 TACLSWGLQAMAPYAPFVASELLQHVPLNI-------------ELKLSDYKDEKLEEEVNEIVNI 839
            ..||..||:.::|:.|||..||.|.:|...             |.....:||.:.|..:...::|
Mouse  1049 YTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSECSWKDPEAEAALELALSI 1113

  Fly   840 CHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDE-----SSK 899
            ...||.:::...:: |..|                             |..||:.||     :|.
Mouse  1114 TRAVRSLRADYNLT-RTRP-----------------------------DCFLEVADEATGALASA 1148

  Fly   900 ISKQLSYFSTAGAL---------------------CSFGLKLSDGLDLTPEKRDEMQKANAKKLK 943
            :|..:...::||.:                     ||..|:|...:|  |.:  |:.|..||:  
Mouse  1149 VSGYVQALASAGVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVD--PAR--ELGKLQAKR-- 1207

  Fly   944 KLVTELQRYRMRLDN----EAFQLMADKKVKSHFENKVKELEAEINSLTRLAVL 993
               :|.||...||..    .::......:|:...|.|:::.|||:..:.....|
Mouse  1208 ---SEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEAELRKVDEAIAL 1258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ValRS-mNP_001286988.1 PTZ00419 23..989 CDD:240411 408/1023 (40%)
ValRS_core 73..675 CDD:185677 300/615 (49%)
tRNA-synt_1_2 268..391 CDD:290334 61/122 (50%)
Anticodon_Ia_Val 675..812 CDD:153416 51/139 (37%)
VarsNP_035820.3 GST_C_family 92..213 CDD:383119
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..294 2/4 (50%)
PTZ00419 281..1263 CDD:240411 409/1029 (40%)
'HIGH' region 343..353 8/9 (89%)
'KMSKS' region 861..865 3/3 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0525
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S561
OMA 1 1.010 - - QHG53858
OrthoDB 1 1.010 - - D229591at2759
OrthoFinder 1 1.000 - - FOG0001015
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100292
Panther 1 1.100 - - O PTHR11946
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.780

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