DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS-m and vars-1

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_505070.3	Gene:	vars-1 / 179184	WormBaseID:	WBGene00006935	Length:	978	Species:	Caenorhabditis elegans

Alignment Length:	829	Identity:	305/829 - (36%)
Similarity:	452/829 - (54%)	Gaps:	80/829 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ASASSCKRGT-YRMLLPPPNVTGNLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQV 128
            |:|:..|.|: :||:||||||||.|||||||...|:|.|.|.:...|.:.:|:||.|||||||||
Worm    48 AAANYRKNGSLFRMVLPPPNVTGKLHLGHALTVAVEDAICRHQRNQGNKAEWIPGFDHAGIATQV 112

  Fly   129 VVERTIAASQAKTRHELGRSAFLDEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAV 193
            |||: |.|...|.|.|:.|..|:.|...|..:..:.|.|.|.::|..|:|.:.|:|:|.:.:.||
Worm   113 VVEK-ILAKNGKRRLEMTREEFVKECHLWGEKCSSEIRQQLTRMGASLDWTQSYYTLDSKFSEAV 176

  Fly   194 NVAFERLFEEGLIQRRNSVVNWCTALRSAISDIEVDSVEITEPVEI---SVPGYDHKVLFGRMYD 255
            ..||..|.:|.||.|...:|:||..|.|.:|..||:.:::.....|   |..|...:|.||:|:.
Worm   177 TKAFCILEQEDLITRGKRLVHWCPTLSSTLSSQEVNRIDVPSDGYINLSSSSGTRRRVKFGQMHV 241

  Fly   256 FAYHVVDGEALPDGSVEEIVVSTTRPETILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDT-- 318
            ..|::||.|:      |.|.|.||||||:..||||||||.|.||:|:..      ||.:...|
Worm   242 IRYNLVDSES------EFIEVGTTRPETLFADVAVAVHPEDDRYSKFHG------KHVWSPVTPG 294

  Fly   319 --IPLVFDITVDQEFGTGAVKITPAHDKFDFELATRHKLEPRQVFTETGLVVDAY-------SEY 374
              :.::.|..|..|.|||||||||:||..|:|:..|..|...|...|....:||.       .::
Worm   295 RKLFVITDSAVSVEKGTGAVKITPSHDALDYEIWNRWILNAGQNTIEEFACIDAEGKMTNSGEDF 359

  Fly   375 KGIPRFEARDLIVNRLEEMDLLRQVRSHT-MQLPICSRSKDVIEYMILPQWFLKCKDLAKDALSE 438
            .|:.|||||:.::.:|.|:.....:..|. .|:.||||:.|:||..:..||||.|||:...:...
Worm   360 DGMDRFEAREKVIQKLSELGNYNGLMKHEGAQVNICSRTGDIIEPRLTEQWFLDCKDMFARSADA 424

  Fly   439 LHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPAYEVIDSQGNSQWVAALDEKTARQK 503
            :.||::::.|.........|.::...||:||||||||::|||.|   .|.|:|:...||:.||
Worm   425 IKSGKIEVFPEYQSHRLADWFENQEPWCLSRQLWWGHRIPAYNV---PGQSKWMVTTDEEEAR-- 484

  Fly   504 AMRLIGSEEFTLKRDPDVLDTWFSSSLLPFSTAGWPEESYKERYPLDIMQTGHDIIFFWVARMMM 568
              |.:|.:   :::|||||||||||:|:|....||.|.:..:...|::|:||.||..||||||:.
Worm   485 --RELGDK---MQQDPDVLDTWFSSALVPLVKNGWLEGAPIQTPSLNVMETGWDISGFWVARMIA 544

  Fly   569 LGLKL-TGEAPFQRILLNGIVCDAHGRKMSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIIT 632
            |.:|| :||.||.:::|:|:|.|..|||||||:||::.|..|:.|.:.|.:...::.|..    .
Worm   545 LNMKLSSGETPFGKVVLHGLVRDNEGRKMSKSLGNVIDPLDVLDGITFEKMIERVKSSAH----E 605

  Fly   633 PSELKASTIGMTQMFPNGIQECGTDALRFTLMSHNIKSHFISFDV-NACHTNKLFLNKVWQAMRF 696
            ..|:..:...:|:.|||||..||.|||||.|:.:::.|..|..|| ||......|.||:|....:
Worm   606 KEEIDNAVKDLTKRFPNGISRCGPDALRFALLKYDVLSTDIPIDVSNAAIEGLHFCNKIWNLAAY 670

  Fly   697 TLGSAKGLGISLHQFETLEGVNLG-LWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQY 760
            ....|:       :.|.::.|:.. |.|.||:.||:.|:|......:.::.|||.:.|..|....
Worm   671 YDQLAE-------KCEVIKDVDSDRLVDEWIMARLSTTVSTVDAHMNKFSLHLALSTLHKFITSD 728

  Fly   761 LCDTYLETTKPAIGN----RSADAYIHVGTLTACLSWGLQAMAPYAPFVASELLQHVPLNIELK- 820
            :||.|||:||.|:.|    |..:|.   ..|...|...|..:..:.|||:..:.:.:     .|
Worm   729 ICDIYLESTKKALWNNDIARIREAR---SILQRVLQPTLVQLNAFMPFVSEYIYERI-----FKR 785

  Fly   821 -----LSD---------YKDEKLEEEVNEIVNICHNVRQVKSRNEISKR 855
                 |.|         :::|:|||.:..|..:...:|..:...::.:|
Worm   786 ETGSILFDVVKPSLFIFHRNEELEEAMKLITAMMAAIRSTRQTLQLPQR 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	305/829 (37%)
		ValRS_core	73..675	CDD:185677	251/618 (41%)
		tRNA-synt_1_2	268..391	CDD:290334	52/133 (39%)
		Anticodon_Ia_Val	675..812	CDD:153416	41/142 (29%)
vars-1	NP_505070.3	PTZ00419	54..971	CDD:240411	303/823 (37%)
		nt_trans	59..648	CDD:294020	250/615 (41%)
		tRNA-synt_1_2	242..375	CDD:290334	56/144 (39%)
		Anticodon_Ia_Val	656..782	CDD:153416	37/135 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780