DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS-m and glp-4

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_493377.1	Gene:	glp-4 / 173224	WormBaseID:	WBGene00006936	Length:	1050	Species:	Caenorhabditis elegans

Alignment Length:	1006	Identity:	390/1006 - (38%)
Similarity:	562/1006 - (55%)	Gaps:	75/1006 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDAANELPLAAGYQPQPVEN---AYWERE--HRQANLPKASASSCKRGTYRMLLPPPNVTGNLHL 90
            |....|:|  |.|.|..||:   ::||:|  .:...:.|.:..|....::.:.:||||||||||:
Worm    73 KKIDGEIP--AAYFPGYVESGWYSWWEKEGFFKPEYIDKLNPGSNPADSFTVCIPPPNVTGNLHV 135

  Fly    91 GHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLDEVW 155
            ||||..||:|.|.|.....|.:..:.||.||||||||||||:.:...:..|||:|||..|..|||
Worm   136 GHALATTVEDTITRFNRMHGKRTLFNPGCDHAGIATQVVVEKRLKRERGLTRHDLGRDRFNQEVW 200

  Fly   156 RWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCTALR 220
            .||.|||..|....|:||..::|.|..||||.:...||..||.|:.|.|.|.|.|.:|||..|||
Worm   201 HWKNEKGDVIYDQFRKLGASVDWDRAVFTMDPKMCRAVTEAFIRMHESGTIYRSNRLVNWSCALR 265

  Fly   221 SAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPETIL 285
            |||||||||..|:|....|:|||||.|:.||.:..|||.:       .||.|||||||||.||:|
Worm   266 SAISDIEVDKKELTGSTLIAVPGYDKKIEFGVLNSFAYKI-------QGSDEEIVVSTTRIETML 323

  Fly   286 GDVAVAVHPLDPRYAKYRNIDQVKLKHPF-RDDTIPLVFDITVDQEFGTGAVKITPAHDKFDFEL 349
            ||..|||||.|.|   |:::...:..||| ....:|:..|..|:.||||||||||||||..|:|:
Worm   324 GDSGVAVHPDDQR---YKHLVGKQCIHPFIPTRNLPIFADSFVEMEFGTGAVKITPAHDHNDYEV 385

  Fly   350 ATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSRSKD 414
            ..|..|......|:.||:.....|:.|:.||:||..::..|:|..|.|....:.|.:|.||||||
Worm   386 GIRQNLPFHNCITDDGLISQGCGEFSGMKRFDARTAVIEALKEKGLYRGKEDNPMVVPTCSRSKD 450

  Fly   415 VIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQVPA 479
            |||.::.|||::||..:|:.|::.:.:|.|||:|...:..|.|||:.||||||||||||||::||
Worm   451 VIEPILKPQWYVKCAHMAEKAVAAVANGDLQIIPEFHKATWNRWLESSRDWCISRQLWWGHRIPA 515

  Fly   480 YEVIDSQGNSQ-------WVAALDEKTARQKAMR--LIGSEEFTLKRDPDVLDTWFSSSLLPFST 535
            |.:..:.|..|       ||:|..|:.|..||.:  .:...|..||.|.|||||||||.:.||:.
Worm   516 YYISFADGREQPLPEENYWVSARTEQEALAKAAQKFQVPEAEILLKWDEDVLDTWFSSGMWPFAV 580

  Fly   536 AGWPEESYKER---YPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMS 597
            .|||:.: |:.   :|..:::|||||:|||||||:.:..:|||:.||:.|||:.::.||||||||
Worm   581 FGWPDAT-KDMDLFFPGAVLETGHDILFFWVARMVFMAQELTGKLPFKEILLHAMIRDAHGRKMS 644

  Fly   598 KSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFT 662
            ||:||::.|..|::|.||..|:|.|    ..|.:...|:..:..|..:.:|:||.|||.|||||.
Worm   645 KSLGNVIDPLDVIRGISLNDLQAQL----LGGNLDEKEIAVAKEGQARDYPDGIPECGVDALRFA 705

  Fly   663 LMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGVNLGL---WDR 724
            |:|:..:...|:.||...|..:.|.||:||.:||.|..   :.....|..|.| :||..   .|.
Worm   706 LLSYTSQGRDINLDVLRVHGYRKFCNKLWQVVRFALAR---ISDKPEQKPTFE-INLKSATPTDL 766

  Fly   725 WIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-GNRSADAYIHVGTLT 788
            ||:.|||:.:...:::...|||..||.....|:....||.|:||.||.: |:.:....:.:..|.
Worm   767 WILSRLAKAVKETNEALKAYNFTQATTVTYNFWLYDFCDVYVETIKPVLYGDNTTLRQVAISVLH 831

  Fly   789 ACLSWGLQAMAPYAPFVASELLQHVP----------------LNIELKLSDYKDEKLEEEVNEIV 837
            .|:..||:.::|..||::.||.|.:|                ..:..|...|::||||.......
Worm   832 KCIDTGLRLISPLMPFISEELWQRMPRLDDSDYTSPSIIVAQYPLTQKYEKYQNEKLEAAFEFAQ 896

  Fly   838 NICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELELFDESSKISK 902
            .:...||.:::..:: |:....:.:.::..:.|.:|......|..|:..|.|.:....||.||.|
Worm   897 ELIGKVRSLRADYDL-KKTKITMQILSETPEDESMLNDISAVITTLTFSEKVSILNKCESDKIEK 960

  Fly   903 QLSYFSTAGALCSFGLKLSDGLDLTPEKRDEMQKANAKKLK-----KLVTELQR---YRMRLDNE 959
            ..::.: .|..|...:.|:..:|: |:   |::|..||..|     |.:.::|.   |..::..:
Worm   961 GSAHIA-CGGRCQVYINLTGIIDV-PK---EIEKLGAKLQKNQISVKKIGDIQSSADYEQKVPVD 1020

  Fly   960 AFQLMADKKVKSHFENKVKELEAEINSLTRL 990
            ...|  |::.|:..|.:::.:.|.|..|..|
Worm  1021 IRAL--DQEKKATLEKEIENITAAIAQLKAL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	389/1003 (39%)
		ValRS_core	73..675	CDD:185677	289/614 (47%)
		tRNA-synt_1_2	268..391	CDD:290334	57/123 (46%)
		Anticodon_Ia_Val	675..812	CDD:153416	45/140 (32%)
glp-4	NP_493377.1	PTZ00419	51..1050	CDD:240411	390/1006 (39%)
		ValRS_core	118..718	CDD:185677	289/614 (47%)
		tRNA-synt_1_2	301..426	CDD:290334	60/134 (45%)
		Anticodon_Ia_Val	718..856	CDD:153416	46/141 (33%)
		Val_tRNA-synt_C	982..1047	CDD:287436	16/70 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S561
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.780