DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ValRS-m and vars1

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001298275.1	Gene:	vars1 / 114427	ZFINID:	ZDB-GENE-010601-1	Length:	1271	Species:	Danio rerio

Alignment Length:	1009	Identity:	391/1009 - (38%)
Similarity:	576/1009 - (57%)	Gaps:	95/1009 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDAANELPLAAGYQPQPVENA---YWER------EHRQANLPKASASSCKRGTYRMLLPPPNVTG 86
            ||..:  ||...|.||.||.|   :||:      |:.:..|.:.:    .||.:.|.:|||||||
Zfish   295 KDVLS--PLPDSYSPQYVEAAWYSWWEKQGFFKPEYGRKKLSEPN----PRGVFMMCIPPPNVTG 353

  Fly    87 NLHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFL 151
            :|||||||...:||.:.|.....|....|.||.||||||||||||:.:...:..|||:|||..|:
Zfish   354 SLHLGHALTNAIQDCLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLMRERKMTRHDLGRENFI 418

  Fly   152 DEVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWC 216
            .|||:||.|||..|...|::||..|:|.|..||||::.:.||..||.|:.|||:|.|...:|||.
Zfish   419 KEVWKWKNEKGDRIYHQLKKLGSSLDWDRACFTMDDKLSFAVQEAFIRMHEEGVIYRSKRLVNWS 483

  Fly   217 TALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRP 281
            ..|.|||||||||..|:|....:.||||..||:||.:..|:|.:       :||.||::|:|||.
Zfish   484 CTLNSAISDIEVDKKELTGRTLLPVPGYKDKVVFGVLVSFSYKI-------EGSDEEVIVATTRI 541

  Fly   282 ETILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFD 346
            ||:|||.||||||.|.|   |:::....:.|||.|..:|:|||..||..|||||||||||||..|
Zfish   542 ETMLGDTAVAVHPEDSR---YKHLKGKMVIHPFCDRKMPVVFDDFVDMNFGTGAVKITPAHDHND 603

  Fly   347 FELATRHKLEPRQVFTETGLVVDAYSEYKGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSR 411
            :|:..||||....:..|.||:::....:.|:.|||||..::..|::....::|:.:.|.:|:|||
Zfish   604 YEVGERHKLPFINILDENGLLINVPPPFLGMKRFEARTAVLQALKDRGQFKEVKDNPMVVPVCSR 668

  Fly   412 SKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQ 476
            |||::|.::.|||::.|:::.|.|...:.:|.|:|:|.:....|..|:.:.|||||||||||||:
Zfish   669 SKDIVEPLLKPQWYVDCREMGKQAADVVRNGELKIIPDHHLKTWFNWMDNIRDWCISRQLWWGHR 733

  Fly   477 VPAYEVI----------DSQGNSQWVAALDEKTARQKAMRL--IGSEEFTLKRDPDVLDTWFSSS 529
            :|||.|.          |..|: .||:...|:.||:||.:.  :.:::.:|::|.|||||||||.
Zfish   734 IPAYFVTVNDPAVKPGEDVDGH-YWVSGRSEQEAREKAAKRFNVTADKISLRQDEDVLDTWFSSG 797

  Fly   530 LLPFSTAGWPEESYKER--YPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAH 592
            :.|||..|||.||...|  ||..:::|||||:|||||||:|:||||||:.||:.:.|:.:|.|||
Zfish   798 IFPFSIFGWPNESEDLRVFYPGTLLETGHDILFFWVARMVMMGLKLTGKLPFKEVYLHAVVRDAH 862

  Fly   593 GRKMSKSIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTD 657
            |||||||:||::.|..|:.|.|||.|.|.|..|    .:.|.|::.:..|....:|.||.|||||
Zfish   863 GRKMSKSLGNVIDPLDVITGISLEGLYAQLADS----NLDPLEIEKAKQGQKSDYPTGIPECGTD 923

  Fly   658 ALRFTLMSHNIKSHFISFDVNACHTNKLFLNKVWQAMRF---TLGSAKGLGISLHQFETLEGVNL 719
            ||||.|.::..:...|:.|||.....:.|.||:|.|::|   |||..         |...|...|
Zfish   924 ALRFALCAYTSQGRDINLDVNRILGYRHFCNKLWNAVKFAMRTLGEG---------FVPCEKAQL 979

  Fly   720 ----GLWDRWIVGRLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI------G 774
                .:.||||:.||:..:::|...:..|:|...|.|:..|:...|||.|||..||..      |
Zfish   980 CGSESVSDRWILSRLSAAVALCDGGFKAYDFPTITTAIYNFWLYELCDVYLECVKPVFSRTDSKG 1044

  Fly   775 NRSADAYIHVGTLTACLSWGLQAMAPYAPFVASELLQHVPLN------IELKLSDYKD------- 826
            .:.||  :...||..||..||:.::|..|||:.||.|.:|..      ..:.::.|.|
Zfish  1045 QKQAD--VCRQTLYTCLEVGLRLLSPIMPFVSEELFQRLPRRRPRDSPPSISVTPYPDTAEFCWH 1107

  Fly   827 -EKLEEEVNEIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSE--GVLRRHLPQIKVLSRCED 888
             |.::.::..::::...:|.:::...::|   .:...|.|..|||  .:::::..||:.||..:.
Zfish  1108 SEDVDRQMEFVMSVVRTIRSLRADYNLTK---TRADCFLQCIDSETAALVQKYSLQIQTLSYSQA 1169

  Fly   889 VELELFDESSKISKQLSYFSTAGALCSFGLKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQRYR 953
            |...:.|.:   ..|....:.|...|:..|.|...:||    ..|:.|..||| .:|..::::.:
Zfish  1170 VHSVVGDAA---IPQGCAVAIASDKCTVNLMLKGLIDL----GKEVTKLTAKK-GELEKQMEKMK 1226

  Fly   954 MRLDNEAFQLMADKKVKSHFENKVKELEAEINSL 987
            .::....::.....||:.....|:::.|||:..:
Zfish  1227 EKMTKNDYKEKVPVKVQEADAEKLRQSEAELQKV 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	391/1009 (39%)
		ValRS_core	73..675	CDD:185677	289/615 (47%)
		tRNA-synt_1_2	268..391	CDD:290334	60/122 (49%)
		Anticodon_Ia_Val	675..812	CDD:153416	50/149 (34%)
vars1	NP_001298275.1	GstA	<45..192	CDD:223698
		GST_C_ValRS_N	80..202	CDD:198327
		PTZ00419	291..1270	CDD:240411	391/1009 (39%)
		ValRS_core	340..941	CDD:185677	289/615 (47%)
		tRNA-synt_1_2	518..643	CDD:290334	63/134 (47%)
		Anticodon_Ia_Val	941..1081	CDD:153416	51/150 (34%)
		Val_tRNA-synt_C	1203..1266	CDD:287436	14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930