DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ValRS-m and vars2

DIOPT Version :9

Sequence 1:	NP_001286988.1	Gene:	ValRS-m / 39023	FlyBaseID:	FBgn0035942	Length:	994	Species:	Drosophila melanogaster
Sequence 2:	NP_001124133.1	Gene:	vars2 / 100170827	ZFINID:	ZDB-GENE-060503-575	Length:	1057	Species:	Danio rerio

Alignment Length:	1008	Identity:	387/1008 - (38%)
Similarity:	555/1008 - (55%)	Gaps:	93/1008 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KDAANELPLAAGYQPQPVE---NAYWERE-----HRQANLPKASASSCKRGTYRMLLPPPNVTGN 87
            ||..  ||....|.|:.||   ..:||::     .:.:..|.|....     :.:.:|||||||.
Zfish    81 KDTT--LPFPQSYSPEYVEFGWYQWWEKQGFFSPEQHSKQPHAVDKH-----FSLCIPPPNVTGT 138

  Fly    88 LHLGHALMATVQDVIARQREQLGYQVDWVPGTDHAGIATQVVVERTIAASQAKTRHELGRSAFLD 152
            |||||||...::|.:||.|...||:|.||||.||||||||.||||.:...|.|:|.:..|..||.
Zfish   139 LHLGHALTVAIEDALARWRRMQGYKVLWVPGCDHAGIATQSVVERKLLREQGKSRQDFSREEFLK 203

  Fly   153 EVWRWKAEKGAGIVQDLRQLGCKLNWQREYFTMDEQQAHAVNVAFERLFEEGLIQRRNSVVNWCT 217
            :||.||.|||..|...||:||..|:|.|..||||...:.||..||.||.:.|||.|...::||..
Zfish   204 QVWMWKNEKGDEIYHQLRKLGASLDWSRACFTMDPAFSSAVTEAFVRLCDSGLIYRAEGLINWSC 268

  Fly   218 ALRSAISDIEVDSVEITEPVEISVPGYDHKVLFGRMYDFAYHVVDGEALPDGSVEEIVVSTTRPE 282
            .|.||||||||||.|:.....:|||||..||.||.|..|||.:       :|...|:.|||||||
Zfish   269 TLESAISDIEVDSKELPGRTLLSVPGYQQKVEFGTMVTFAYPL-------EGQEGEVAVSTTRPE 326

  Fly   283 TILGDVAVAVHPLDPRYAKYRNIDQVKLKHPFRDDTIPLVFDITVDQEFGTGAVKITPAHDKFDF 347
            |:|||||:||||.|||   |:::...:.:|||.:..:|:|.|.|||..|||||||:|||||..||
Zfish   327 TMLGDVAIAVHPDDPR---YKHLHGKRCRHPFTEQLLPIVTDTTVDMTFGTGAVKLTPAHDHTDF 388

  Fly   348 ELATRHKLEPRQVFTETGLVVDAYSEY-KGIPRFEARDLIVNRLEEMDLLRQVRSHTMQLPICSR 411
            .|:.:|.|....|....|.:.....:: :|:.||:||:.:::.|.|..|.|..:.|.|.||||||
Zfish   389 LLSQKHSLPRLTVIGGNGTMTSVCGQWLEGVKRFDARERVISALMERKLFRGKKDHPMSLPICSR 453

  Fly   412 SKDVIEYMILPQWFLKCKDLAKDALSELHSGRLQILPPNFETEWERWLQDSRDWCISRQLWWGHQ 476
            |.||||.::..|||::|:::||.|:..:..|.|||:|..:...|:.||.:..|||:|||||||||
Zfish   454 SGDVIEPLLKKQWFVRCQEMAKKAVQAVEEGDLQIIPQFYSKMWKSWLSNISDWCVSRQLWWGHQ 518

  Fly   477 VPAYEV-IDSQGNSQ---WVAALDEKTARQKAMRLIG--SEEFTLKRDPDVLDTWFSSSLLPFST 535
            :|||.| :.:..|::   ||.......|:|:|....|  .|..||.:|||||||||||.|.||:.
Zfish   519 IPAYRVTLQNSMNTEEEHWVWGRSAAEAQQRATIKFGVNPEAITLTQDPDVLDTWFSSGLFPFAM 583

  Fly   536 AGWPEES--YKERYPLDIMQTGHDIIFFWVARMMMLGLKLTGEAPFQRILLNGIVCDAHGRKMSK 598
            .|||:::  ..:.||..|::||.|:||||||||:|||.:|||:.||:::|.:.:|.|.:||||||
Zfish   584 LGWPQQTKDLTQFYPNSILETGSDLIFFWVARMVMLGTELTGQLPFKQVLFHSLVRDKYGRKMSK 648

  Fly   599 SIGNIVAPQQVVQGASLESLKAGLEQSCEAGIITPSELKASTIGMTQMFPNGIQECGTDALRFTL 663
            |:||::.|..|:.|.|||.    |::..:.|.:.|.|...:.....:.||.||.|||||||||.|
Zfish   649 SLGNVIDPLDVISGVSLER----LQEKVKEGNLDPRESIVAIEAQKKDFPKGIPECGTDALRFAL 709

  Fly   664 MSHNIKSHFISFDVNACHTNKLFLNKVWQAMRFTLGSAKGLGISLHQFETLEGVNLGLWDRWIVG 728
            .|:..:...||..::...:.:.|.||:||.:||||.:.....:.....||..   |...|:||..
Zfish   710 CSYRAQGEDISLSMSHVLSCRHFCNKMWQTVRFTLATLNDASLPTPLAETYP---LSSMDKWICS 771

  Fly   729 RLAETLSVCSQSYSNYNFHLATAALKTFFYQYLCDTYLETTKPAI-----GNRSADAYIHVGTLT 788
            ||..|:..|.|.:.:|..:..|:||.:|:...|||.|||:.||.:     ..|..:..:....|.
Zfish   772 RLYSTVKECEQGFESYELYTVTSALHSFWLHCLCDVYLESIKPLLKPEGCEERVGERQVATSVLY 836

  Fly   789 ACLSWGLQAMAPYAPFVASELLQHV-------PLNIELKLSDY-KDEKLE------EE-----VN 834
            ..:|..|..::|:.||:..||.|.:       ..:..|.:..| |..:||      ||     |.
Zfish   837 HSVSVSLALLSPFMPFLTEELWQRLLPYGHFDKTSCSLCVQPYPKTSQLEHWYFPKEEADFSLVQ 901

  Fly   835 EIVNICHNVRQVKSRNEISKRHHPQLSLFAQNTDSEGVLRRHLPQIKVLSRCEDVELEL----FD 895
            |:|.:   .|.::::.:::|......::.|  .|...:|.|....|..|.|...:.|..    |.
Zfish   902 EVVRV---TRLLRAQCQMTKEKPDLYAVCA--PDQMEILLRFRSAICTLGRISTLHLHCPEAGFS 961

  Fly   896 E--SSKISKQLSYFSTAG----ALCSFGLKLSDGLDLTPEKRDEMQKANAKKLKKLVTELQRYRM 954
            :  |:|.       |..|    :|| ..|...:|::     .|:.:....::.:||..:|::...
Zfish   962 DCPSAKA-------SAVGVVDHSLC-LHLSAQNGVN-----ADKQRAILCQRREKLAFKLKQALA 1013

  Fly   955 RLDNEAFQLMADKKVKSHFENKVKELEAEINSL 987
            |....::.....:||:...|||:..:|.|:.::
Zfish  1014 RTQTHSYIEKVPQKVRQEMENKITAMEQEMKNI 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ValRS-m	NP_001286988.1	PTZ00419	23..989	CDD:240411	387/1008 (38%)
		ValRS_core	73..675	CDD:185677	290/610 (48%)
		tRNA-synt_1_2	268..391	CDD:290334	56/123 (46%)
		Anticodon_Ia_Val	675..812	CDD:153416	42/141 (30%)
vars2	NP_001124133.1	PTZ00419	66..1054	CDD:240411	387/1008 (38%)
		ValRS_core	124..721	CDD:185677	290/615 (47%)
		tRNA-synt_1_2	302..>402	CDD:290334	54/109 (50%)
		Anticodon_Ia_Val	721..861	CDD:153416	43/142 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53858
OrthoDB	1	1.010	-	-		D229591at2759
OrthoFinder	1	1.000	-	-		FOG0001015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100292
Panther	1	1.100	-	-	O	PTHR11946
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830