DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GNBP3 and GNBP2

DIOPT Version :9

Sequence 1:	NP_523986.2	Gene:	GNBP3 / 39020	FlyBaseID:	FBgn0040321	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_524141.1	Gene:	GNBP2 / 40033	FlyBaseID:	FBgn0040322	Length:	461	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	142/527 - (26%)
Similarity:	225/527 - (42%)	Gaps:	124/527 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CLQLLFLLLGVQGYEVPKAKIDVFYPKGFEVSIPDEEGITLFAFHGKLNEEMEGLEAGTWARD-I 76
            ||.||.....:.|::||....::...:|||||||||.||....:..::::....|      .| |
  Fly     8 CLLLLISNNKIFGFKVPSINFEMLKDEGFEVSIPDEPGIQRVFYMFQIDDTCPAL------MDYI 66

  Fly    77 VKAKNGRWTFRDRITALKPGDTLYYWTYVIYNGLGYREDDGSFVVNGYSGNNASPHPPVVPVSTT 141
            .:|.||.|..:.:: :|:..|.|.....|.:|...:.:.:...::|             ..:.||
  Fly    67 TEAVNGSWVSKQKM-SLQNNDKLQISMLVQFNEEIFEKSETRVIIN-------------TRLLTT 117

  Fly   142 ------------------PWTPPADPDIDIRLGCTTPKTEVNGAPTRCAGQLVFVDEFNAAKLDP 188
                              .:..||..    ...|...:|.|:.....|.|:|:|.|.|:.|:|:.
  Fly   118 KDSSSRGITFLTGEGECQAYLAPAQQ----AKRCKAAQTIVSNGRHTCQGELIFEDNFSEAQLNK 178

  Fly   189 NKWKAERRFSGQPDYEFNVYVDDAPETLCLANG--HVV--LSTNTMKKQFKKGSGESLDLGEKCT 249
            ..||.:.|.......|..|..|||.....:..|  |:|  ::|......||        ||::||
  Fly   179 TTWKHDIRQRMYHVEEELVAFDDAARNCFVKEGELHIVPTIATEVTDGSFK--------LGDRCT 235

  Fly   250 G-QANTHDCVRNGRTLNDGL-----PPMVTAQFSSKD-FSFKYGRVEVRAKMPRAQWVTPQIWLQ 307
            . ::...:|     .:..|:     ||:.:||..::: ||||:|::.||||:|:..|:.|.:.||
  Fly   236 AVESPEQEC-----NIAHGIFYSIKPPVFSAQIHTRNSFSFKFGKIVVRAKLPKGDWLFPYLMLQ 295

  Fly   308 PRRPIYGVDDYRSGQLRIAYTRPN-----------GGNLDLYGAAVLFADEPLRSVKNCLKPGTG 361
            | ...|....| :.||||||.|.|           .|| .|||..|::..   .:....||....
  Fly   296 P-VSTYAETHY-AKQLRIAYARGNANLRTKQGDDISGN-HLYGGGVVWHH---GNAVQFLKDKIS 354

  Fly   362 NNSEDWSDSFHNYTLEWTPRELRWLVDGKEWCVQGSAKGSFSETTAAGKSLPQAQKLEEGTGLAP 426
            |:  .:.|.|||||:.|...::..:||.:   |.|                      |...||..
  Fly   355 NS--HYGDDFHNYTMIWQRDKITLMVDDE---VYG----------------------ELYDGLPF 392

  Fly   427 FDQEFYLTFGLSVGGFNEYQ-----HEIKPWNERAPQAQKAFWKEVKKIRDHWLD----EGHMKI 482
            |:::.::.||::||||..:.     .::||:..|.|:|..:||:.    ||.|..    ...|.|
  Fly   393 FNEKCFIIFGVTVGGFLNFDDSLLAKDVKPYKNREPRAALSFWQH----RDAWAPTWGRHSAMVI 453

  Fly   483 DYVKVYS 489
            |||:||:
  Fly   454 DYVRVYA 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GNBP3	NP_523986.2	CBM39	27..132	CDD:292510	26/105 (25%)
GNBP3	NP_523986.2	GH16_beta_GRP	175..489	CDD:185688	101/344 (29%)
GNBP2	NP_524141.1	CBM39	22..120	CDD:292510	28/117 (24%)
GNBP2	NP_524141.1	GH16_beta_GRP	165..460	CDD:185688	101/344 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26300
OrthoDB	1	1.010	-	-		D105633at50557
OrthoFinder	1	1.000	-	-		FOG0006727
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.960