DRSC/TRiP Functional Genomics Resources

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Protein Alignment LAG3 and igsf9bb

DIOPT Version :9

Sequence 1:NP_002277.4 Gene:LAG3 / 3902 HGNCID:6476 Length:525 Species:Homo sapiens
Sequence 2:XP_009293693.1 Gene:igsf9bb / 569554 ZFINID:ZDB-GENE-091112-15 Length:1439 Species:Danio rerio


Alignment Length:557 Identity:113/557 - (20%)
Similarity:179/557 - (32%) Gaps:171/557 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    62 TWQHQPDSGPPAAAPGHP-----LAPGPHPAAPSSWG-PRPRRYTVLSVGPGGLRSGRLPLQPRV 120
            :|.|...:.||......|     ...|....:.:::| |:|      ||  ..||.|. |:|   
Zfish   127 SWVHLTVNAPPTFTDTPPQYVEAKEGGSITLSCTAFGNPKP------SV--SWLREGN-PVQ--- 179

Human   121 QLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMT-----------AS 174
              |....:..|.||.|....|.|.|.|           :||.....|:|..|           .|
Zfish   180 --DSTKYKVSDGSLTLVSISREDRGAY-----------TCRAYSEQGEAVHTTRLLVQGPPFIVS 231

Human   175 PPGSL--RASDWVILNCSFSRPDRPASVHW--------FRNRGQGRVPVRESPHHHLAESFLFLP 229
            ||.::  ..|......|.........:..|        |:|..:.||.:       |.:..|.:.
Zfish   232 PPENITVNISQDAFFTCQAEAYPGNLTYTWFWEEDNVFFKNDLKRRVSI-------LIDGSLIIS 289

Human   230 QVSPMDSGPWGCILTYRDG------FNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGV 288
            ||.|.|:|.:.|..:...|      ..:::.|...|:.:.|    .:|..    :|||..:...|
Zfish   290 QVKPEDAGKYTCSPSNSLGRPPSASAYLTVHYPARVINMPP----VIYVA----IGLPGYIRCPV 346

Human   289 GTRSFLTA-KWTPPG---------GGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLN 343
            .....:|: ||...|         |...:      .|.::|:.:|::...|||||      ...|
Zfish   347 DANPPVTSVKWKKDGLPLRIEKYPGWSQM------EDGSIRVSEVTEDSLGTYTC------VPYN 399

Human   344 ATVTLA-------IITVTPKSFGSPGSLGKLLCEVTPVSGQE-------------RFVW-SSLDT 387
            :..|:.       ::...||....||.      |....:|:|             ...| ..:..
Zfish   400 SLGTMGPSPPAPLVLKDPPKFLVVPGG------EYRQEAGRELVIPCEAEGDPFPNITWRKKVGK 458

Human   388 PSQRSFSGPWLEAQEAQLLSQ----PWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAG 448
            ||:...:.....:.:.:.||:    .|:|........:.|:.:...:        |.:|.|....
Zfish   459 PSRSKHNVLPRGSLQFKSLSKEDHGEWECVASNVATSITASTHLLVI--------GTSPHAPAKV 515

Human   449 HLLLFLILGVLSLLLLVTGAF--GFHLW------RRQWRPRRFSA----------LEQGIHPPQ- 494
            |:.:......:|......|.|  .|.:|      |.|..|..:.:          |.||:.|.. 
Zfish   516 HVTVSTTSANVSWDSSYDGGFEQTFSVWYGHVVKREQLGPHDWLSMPVPSGQHWLLVQGLEPETA 580

Human   495 ------AQSKIEELEQEPEPE---------PEPEPEP 516
                  ||:|   |...|..|         |...|||
Zfish   581 YQFSVLAQNK---LGTGPFSEVVTVNTLVFPISTPEP 614

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAG3NP_002277.4 Interaction with FGL1. /evidence=ECO:0000269|PubMed:30580966, ECO:0000269|PubMed:9159144 37..252 49/222 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 62..97 8/40 (20%)
Ig_2 174..259 CDD:290606 20/100 (20%)
IG_like 185..259 CDD:214653 16/87 (18%)
Ig 263..336 CDD:299845 19/82 (23%)
IG_like 267..348 CDD:214653 19/90 (21%)
Connecting peptide. /evidence=ECO:0000250|UniProtKB:Q61790 429..450 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..525 13/46 (28%)
KIEELE motif. /evidence=ECO:0000250|UniProtKB:Q61790 498..503 1/4 (25%)
12 X 2 AA tandem repeats of E-X 501..524 7/25 (28%)
igsf9bbXP_009293693.1 IG_like 30..113 CDD:214653
Ig 41..113 CDD:143165
IG_like 144..223 CDD:214653 26/103 (25%)
IGc2 151..208 CDD:197706 21/81 (26%)
I-set 227..319 CDD:254352 19/98 (19%)
Ig <263..319 CDD:299845 13/62 (21%)
Ig_2 326..414 CDD:290606 21/107 (20%)
IG_like 329..403 CDD:214653 20/93 (22%)
IG_like 424..504 CDD:214653 13/85 (15%)
Ig 440..504 CDD:299845 8/63 (13%)
FN3 509..604 CDD:238020 21/97 (22%)
FN3 620..704 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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