DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAG3 and hspg2

DIOPT Version :9

Sequence 1:	NP_002277.4	Gene:	LAG3 / 3902	HGNCID:	6476	Length:	525	Species:	Homo sapiens
Sequence 2:	XP_021325650.1	Gene:	hspg2 / 565429	ZFINID:	ZDB-GENE-080807-4	Length:	3701	Species:	Danio rerio

Alignment Length:	409	Identity:	89/409 - (21%)
Similarity:	135/409 - (33%)	Gaps:	104/409 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    69 SGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFS 133
            :||.....|.|:    :....::..|||           .:|..||....:..|...........
Zfish  2431 AGPVRVRVGDPI----NLECQAAGEPRP-----------SVRWHRLDNNRKTMLSSTVPVDSSAI 2480

Human   134 LWLRPARRADAGEYRAAVHLRDRALSCRLRLRL-GQASMTASPPGSLRASDWVI-------LNC- 189
            :.:..||..|:|.|..:..........|:.:.: |...:...|..|:|....::       |:|
Zfish  2481 IQVLVARPEDSGTYVCSAQNNQGTTETRVEVFVEGGPQVPTVPRASVREPMIIVVEGSTATLHCD 2545

Human   190 --SFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFN-V 251
              .|.:|    ::.||:.|..  :|.|    |.:.::.|.||.|...|||.:.|..|...|.: |
Zfish  2546 AHGFPKP----TITWFKERSS--LPWR----HKIVDNSLILPNVGRQDSGQYVCNATNHLGTSEV 2600

Human   252 SIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDF 316
            :||..:..    ||...::......|||...||.........|..:||...|..........||.
Zfish  2601 TIMLEVDT----PPYATSLPNDVSVRVGEVIRLQCLAHGTPPLRYEWTKINGSLPSTAQLQGGDL 2661

Human   317 TLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFV 381
            .:.|  ..:..||||.|                   |.....|...:|.|:            .|
Zfish  2662 QINL--AKENDAGTYRC-------------------VASNKVGKSEALAKV------------SV 2693

Human   382 WSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQ----RSGRAP 442
            .|||...     ..|.:|.                  :.||:||.||..:..|.|    :.|
Zfish  2694 RSSLSVK-----VSPQVEV------------------KALGSAVEFTCAAKGGLQIEWLKEG--- 2732

Human   443 GALPAGHLLLFLILGVLSL 461
            |.||..|.:...||.:.:|
Zfish  2733 GVLPPNHHIKDGILRIENL 2751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAG3	NP_002277.4	Interaction with FGL1. /evidence=ECO:0000269\|PubMed:30580966, ECO:0000269\|PubMed:9159144	37..252		41/194 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..97		6/27 (22%)
		Ig_2	174..259	CDD:290606	26/95 (27%)
		IG_like	185..259	CDD:214653	23/84 (27%)
		Ig	263..336	CDD:299845	19/72 (26%)
		IG_like	267..348	CDD:214653	17/80 (21%)
		Connecting peptide. /evidence=ECO:0000250\|UniProtKB:Q61790	429..450		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..525
		KIEELE motif. /evidence=ECO:0000250\|UniProtKB:Q61790	498..503
		12 X 2 AA tandem repeats of E-X	501..524
hspg2	XP_021325650.1	SEA	84..198	CDD:321958
		LDLa	216..251	CDD:238060
		LDLa	277..311	CDD:238060
		LDLa	317..351	CDD:238060
		LDLa	360..395	CDD:238060
		Ig_Perlecan_like	413..490	CDD:143220
		Laminin_B	598..732	CDD:306547
		EGF_Lam	766..814	CDD:238012
		EGF_Lam	831..869	CDD:238012
		Laminin_EGF	871..923	CDD:278482
		Laminin_B	991..1125	CDD:306547
		Laminin_EGF	1159..1206	CDD:278482
		EGF_Lam	1208..1261	CDD:238012
		Laminin_EGF	1272..1315	CDD:278482
		Laminin_B	1536..1671	CDD:306547
		EGF_Lam	1705..1754	CDD:238012
		EGF_Lam	1755..1811	CDD:238012
		IG_like	1823..1903	CDD:214653
		Ig_Perlecan_like	1911..1996	CDD:143231
		I-set	2025..2109	CDD:254352
		I-set	2119..2231	CDD:254352
		I-set	2241..2309	CDD:333254
		Ig_3	2333..2407	CDD:316449
		Ig_3	2427..2500	CDD:316449	16/83 (19%)
		I-set	2517..2606	CDD:254352	26/98 (27%)
		I-set	2610..2693	CDD:333254	22/115 (19%)
		I-set	2699..2778	CDD:333254	18/79 (23%)
		I-set	2785..2867	CDD:254352
		I-set	2871..2954	CDD:254352
		LamG	2961..3119	CDD:238058
		EGF_CA	<3146..3175	CDD:238011
		LamG	3226..3377	CDD:238058
		EGF	3402..3433	CDD:306513
		EGF_CA	3441..3470	CDD:238011
		LamG	3497..3671	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910