DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LAG3 and sdk1a

DIOPT Version :9

Sequence 1:	NP_002277.4	Gene:	LAG3 / 3902	HGNCID:	6476	Length:	525	Species:	Homo sapiens
Sequence 2:	XP_009297968.1	Gene:	sdk1a / 558391	ZFINID:	ZDB-GENE-081104-374	Length:	2245	Species:	Danio rerio

Alignment Length:	446	Identity:	100/446 - (22%)
Similarity:	154/446 - (34%)	Gaps:	147/446 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    18 APVKPLQPGAEVP------VVWAQEGAPAQLPC-SPTIPLQDLSLL-RRAGVTWQHQPDSGPPAA 74
            ||..|:.|...:|      |....|   |.|.| :...|::.|||: ||.||
Zfish   316 APADPVAPVIVIPPRNTTVVAGISE---ATLECVANARPVEKLSLVWRRNGV------------- 364

Human    75 APGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPA 139
                        ...|..|...||.|:::                                   .
Zfish   365 ------------EVASGVGSFSRRLTIIN-----------------------------------P 382

Human   140 RRADAGEYRAAVHLRDRAL---SCRLRLRLGQAS-MTASP----PGSLRASDWVILNCSFSRPDR 196
            ...|.|.|.....|.|.::   ..|..|.:.:|. .||.|    .|.:..|  |.:.|.......
Zfish   383 TSTDVGMYVCEALLLDSSVKPAEARAFLSITEAPYFTAEPRRKMMGEVEKS--VDIQCQARGVPM 445

Human   197 PASVHWFRNRGQGRVPVRE--SPHHHLAESF-LFLPQVSPMDSGPWGC----------ILTYRDG 248
            | .:.|:::    .||:.:  :|.:.:..|. |.:.::.|.|:|.:.|          :.||.|.
Zfish   446 P-KLEWYKD----AVPLSKLNNPRYKIISSMGLQVRKLQPSDAGIFQCFARNSAGEAQVHTYLDV 505

Human   249 FNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRL-----PAGVGTR--------SFLTAKWTP 300
            .:::..:.      .||..:||..||.:  ...||:     ||.|..|        |....::|
Zfish   506 TSMAPAFT------APPLDITVTDGAVA--AFTCRVSGAPKPAIVWRRDTQILASGSVQIPRFT- 561

Human   301 PGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSP---- 361
                  ||.:|.     |:::.|.....|.|||:....|..:||:.:|.:.:.|  |..||
Zfish   562 ------LLESGG-----LQIQPVVLQDTGNYTCYAANSEGAINASASLTVWSRT--SISSPPTDR 613

Human   362 ----GSLGKLLCEVT--PVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQL-LSQPW 410
                |:...|.|..|  |..| .|:||...:.....|..|. :..||..| :||.|
Zfish   614 RVIKGTTAILECGATHDPRVG-VRYVWKKDEELVSHSRGGR-ISLQEGSLHISQTW 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAG3	NP_002277.4	Interaction with FGL1. /evidence=ECO:0000269\|PubMed:30580966, ECO:0000269\|PubMed:9159144	37..252		45/237 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..97		2/34 (6%)
		Ig_2	174..259	CDD:290606	19/101 (19%)
		IG_like	185..259	CDD:214653	16/86 (19%)
		Ig	263..336	CDD:299845	23/85 (27%)
		IG_like	267..348	CDD:214653	24/93 (26%)
		Connecting peptide. /evidence=ECO:0000250\|UniProtKB:Q61790	429..450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..525
		KIEELE motif. /evidence=ECO:0000250\|UniProtKB:Q61790	498..503
		12 X 2 AA tandem repeats of E-X	501..524
sdk1a	XP_009297968.1	I-set	125..208	CDD:254352
		Ig	125..204	CDD:299845
		IG_like	222..302	CDD:214653
		Ig	236..287	CDD:299845
		Ig_3	322..394	CDD:290638	23/134 (17%)
		I-set	323..412	CDD:254352	27/151 (18%)
		I-set	416..505	CDD:254352	20/95 (21%)
		Ig	436..500	CDD:299845	12/68 (18%)
		I-set	510..600	CDD:254352	27/109 (25%)
		Ig	527..600	CDD:299845	21/86 (24%)
		I-set	605..693	CDD:254352	20/65 (31%)
		Ig	610..693	CDD:299845	17/60 (28%)
		FN3	697..788	CDD:238020
		fn3	800..886	CDD:278470
		FN3	901..997	CDD:238020
		FN3	1002..1090	CDD:238020
		FN3	1100..1196	CDD:238020
		FN3	1206..1301	CDD:238020
		FN3	1308..1397	CDD:238020
		FN3	1408..1501	CDD:238020
		FN3	1507..1602	CDD:238020
		FN3	1616..1722	CDD:238020
		FN3	1732..1825	CDD:238020
		FN3	1830..1919	CDD:238020
		FN3	1931..2021	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910