DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAG3 and Lag3

DIOPT Version :9

Sequence 1:	NP_002277.4	Gene:	LAG3 / 3902	HGNCID:	6476	Length:	525	Species:	Homo sapiens
Sequence 2:	NP_032505.1	Gene:	Lag3 / 16768	MGIID:	106588	Length:	521	Species:	Mus musculus

Alignment Length:	529	Identity:	364/529 - (68%)
Similarity:	391/529 - (73%)	Gaps:	12/529 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MWEAQFLGLLFLQPLWVAPVKPLQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQH 65
            |.|...||.|.|..||.|||....||.|:||||||||||..||||...|..|.:.|||.||.|||
Mouse     1 MREDLLLGFLLLGLLWEAPVVSSGPGKELPVVWAQEGAPVHLPCSLKSPNLDPNFLRRGGVIWQH 65

Human    66 QPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRG 130
            |||||.|...|...|    |...||...|.|.|||||||.||||||||.||.|.|||:|||.|||
Mouse    66 QPDSGQPTPIPALDL----HQGMPSPRQPAPGRYTVLSVAPGGLRSGRQPLHPHVQLEERGLQRG 126

Human   131 DFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPD 195
            |||||||||.|.|||||.|.|.|.:|||||.||||:|||||.|||.|.|:.||||:|||||||||
Mouse   127 DFSLWLRPALRTDAGEYHATVRLPNRALSCSLRLRVGQASMIASPSGVLKLSDWVLLNCSFSRPD 191

Human   196 RPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVL 260
            ||.|||||  :||.||||..||.|.|||:||.||||||:|||.|||:|||||||||||.|||.||
Mouse   192 RPVSVHWF--QGQNRVPVYNSPRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVL 254

Human   261 GLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQ 325
            ||||..||||||..||||.|||.||.||||.|.|.||||||||||:|.|.|.:|:|||.||.|..
Mouse   255 GLEPVAPLTVYAAEGSRVELPCHLPPGVGTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGL 319

Human   326 AQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQ 390
            ||||||||.||||.||||||||||:|||||||||.|||.|||||||||.||:|||||..|:..|
Mouse   320 AQAGTYTCSIHLQGQQLNATVTLAVITVTPKSFGLPGSRGKLLCEVTPASGKERFVWRPLNNLS- 383

Human   391 RSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAGHLLLFLI 455
            ||..||.||.|||:||::.||||||:|:|||||.||..| ||.||..:.|..|.|..|||:|.||
Mouse   384 RSCPGPVLEIQEARLLAERWQCQLYEGQRLLGATVYAAE-SSSGAHSARRISGDLKGGHLVLVLI 447

Human   456 LGVLSLLLLVTGAFGFHLWRRQWRPRRFSALEQGIHPPQAQSKIEELEQEPE----PEPEPEPEP 516
            ||.|||.|||.||||||.||:|...|||||||.||.|..||.||||||:|.|    .||||||||
Mouse   448 LGALSLFLLVAGAFGFHWWRKQLLLRRFSALEHGIQPFPAQRKIEELERELETEMGQEPEPEPEP 512

Human   517 EPEPEPEQL 525
            :.||||.||
Mouse   513 QLEPEPRQL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAG3	NP_002277.4	Interaction with FGL1. /evidence=ECO:0000269\|PubMed:30580966, ECO:0000269\|PubMed:9159144	37..252		148/214 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..97		15/34 (44%)
		Ig_2	174..259	CDD:290606	64/84 (76%)
		IG_like	185..259	CDD:214653	57/73 (78%)
		Ig	263..336	CDD:299845	51/72 (71%)
		IG_like	267..348	CDD:214653	60/80 (75%)
		Connecting peptide. /evidence=ECO:0000250\|UniProtKB:Q61790	429..450		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..525		26/41 (63%)
		KIEELE motif. /evidence=ECO:0000250\|UniProtKB:Q61790	498..503		4/4 (100%)
		12 X 2 AA tandem repeats of E-X	501..524		17/26 (65%)
Lag3	NP_032505.1	Interaction with FGL1. /evidence=ECO:0000250\|UniProtKB:P18627	37..246		148/214 (69%)
		ig	168..246	CDD:278476	59/79 (75%)
		IG_like	181..253	CDD:214653	57/73 (78%)
		Ig	261..344	CDD:299845	62/82 (76%)
		IG_like	261..344	CDD:214653	62/82 (76%)
		Connecting peptide. /evidence=ECO:0000305\|PubMed:15557174	422..442		9/20 (45%)
		KIEELE motif. /evidence=ECO:0000269\|PubMed:12421911	490..495		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..521		17/27 (63%)
		13 X 2 AA tandem repeats of E-X	493..518		15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970773
Domainoid	1	1.000	359	1.000	Domainoid score	I13041
eggNOG	1	0.900	-	-		E1_2BYG2
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1719
Inparanoid	1	1.050	694	1.000	Inparanoid score	I9297
Isobase	1	0.950	-	0	Normalized mean entropy	S10135
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39586
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0013845
OrthoInspector	1	1.000	-	-		oto118240
orthoMCL	1	0.900	-	-		OOG6_120563
Panther	1	1.100	-	-	LDO	PTHR11890
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12976
SonicParanoid	1	1.000	-	-		X12735
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.240