DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LAG3 and mxra5a

DIOPT Version :9

Sequence 1:	NP_002277.4	Gene:	LAG3 / 3902	HGNCID:	6476	Length:	525	Species:	Homo sapiens
Sequence 2:	XP_001919144.3	Gene:	mxra5a / 100151112	ZFINID:	ZDB-GENE-090312-22	Length:	2516	Species:	Danio rerio

Alignment Length:	446	Identity:	105/446 - (23%)
Similarity:	148/446 - (33%)	Gaps:	148/446 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    39 PAQLPCSPTIPLQDLS---LLRRAGVTWQHQPDS----GPPAAAP---GHP-------------- 79
            |..|....::|||.|.   .::..|::.:|...|    ..|.|.|   |.|
Zfish  1484 PLNLTLIASVPLQKLPGRLGVQGRGISSEHYTTSEGLQQRPTALPEGRGRPQITSTNIRSVTAHA 1548

Human    80 --------LAPG-PHP---------AAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERG 126
                    :|.| |||         .|..|...|.:|:.|.|       :|.|.:...:.||:
Zfish  1549 ETNAYLPCMAVGKPHPFLTWTKVSTGASISQNTRFQRFEVSS-------NGTLIIHKVIPLDQ-- 1604

Human   127 RQRGDFSLWLRPARRADAGEYRAAVHL-----RDRALSCRLR---LRLGQ-----ASMTASPPGS 178
               |.:..    :.:...||.|..|:|     ..|.|..|.|   ..|||     ......|...
Zfish  1605 ---GQYLC----SVQNQFGEDRIVVNLIVLAEHPRVLQPRYREATAYLGQTIEFECQSKGHPQPR 1662

Human   179 LRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHH---LAESFLFLPQVSPMDSGPWG 240
            :   .||:       |::.. ||       ..||...:|.|.   |....|.:..::.||.|.:.
Zfish  1663 I---TWVL-------PNKEV-VH-------SSVPTHGTPEHMISVLPNGTLHMKSINQMDRGIYK 1709

Human   241 CILTYRDGFNVSIMYNLTVLGLEP------------PTPLTVYAGAGSRVGLPCRLPAGVGTRSF 293
            ||.:...|.: :|...|||..|.|            |...|||....:| |.|   |..:
Zfish  1710 CIASNAAGAD-AISVRLTVATLAPIIQQLSLENVTFPEGSTVYFNCSAR-GAP---PPSI----- 1764

Human   294 LTAKWTPPGG---GPDLLVTGDN----GDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAII 351
               .|..|.|   .|...:.|.|    .:.||.|..:|...||.|.|.:    ..:......|||
Zfish  1765 ---NWITPDGMQLHPSQFINGRNLFVFPNGTLHLHSLSLTDAGRYECSV----TNVIGNARRAII 1822

Human   352 TVTPKS---------FGSP-------GSLGKLLCEVTPVSGQERFVWSSLDTPSQR 391
            ....||         |.||       |....|.| :|..:.:.|.:|.   |||::
Zfish  1823 LTVRKSMKYSRAKITFSSPQKTDVVYGGRLHLDC-ITSGNPEPRIIWR---TPSKK 1874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LAG3	NP_002277.4	Interaction with FGL1. /evidence=ECO:0000269\|PubMed:30580966, ECO:0000269\|PubMed:9159144	37..252		60/270 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..97		15/73 (21%)
		Ig_2	174..259	CDD:290606	20/87 (23%)
		IG_like	185..259	CDD:214653	18/76 (24%)
		Ig	263..336	CDD:299845	23/91 (25%)
		IG_like	267..348	CDD:214653	21/87 (24%)
		Connecting peptide. /evidence=ECO:0000250\|UniProtKB:Q61790	429..450
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	487..525
		KIEELE motif. /evidence=ECO:0000250\|UniProtKB:Q61790	498..503
		12 X 2 AA tandem repeats of E-X	501..524
mxra5a	XP_001919144.3	LRRNT	24..55	CDD:214470
		leucine-rich repeat	35..53	CDD:275380
		LRR_8	52..112	CDD:290566
		leucine-rich repeat	54..77	CDD:275380
		leucine-rich repeat	78..101	CDD:275380
		LRR_8	101..160	CDD:290566
		leucine-rich repeat	102..125	CDD:275380
		LRR_4	125..165	CDD:289563
		leucine-rich repeat	126..149	CDD:275380
		leucine-rich repeat	150..181	CDD:275380
		leucine-rich repeat	182..205	CDD:275380
		LRRCT	214..267	CDD:214507
		IG	478..559	CDD:214652
		Ig	485..545	CDD:143165
		IG	573..657	CDD:214652
		IGc2	581..647	CDD:197706
		I-set	1534..1626	CDD:254352	22/107 (21%)
		Ig	1554..1616	CDD:299845	16/77 (21%)
		I-set	1631..1727	CDD:254352	27/114 (24%)
		Ig	1646..1727	CDD:299845	22/99 (22%)
		IG_like	1740..1825	CDD:214653	25/100 (25%)
		IGc2	1746..1815	CDD:197706	21/84 (25%)
		IG_like	1841..1926	CDD:214653	10/38 (26%)
		IGc2	1849..1916	CDD:197706	9/30 (30%)
		I-set	1932..2030	CDD:254352
		IGc2	1946..2020	CDD:197706
		I-set	2035..2124	CDD:254352
		IGc2	2050..2114	CDD:197706
		Ig	2149..2224	CDD:299845
		IG	2244..2321	CDD:214652
		IGc2	2246..2312	CDD:197706
		IG	2334..2407	CDD:214652
		Ig	2341..2416	CDD:299845
		IG	2429..2515	CDD:214652
		Ig	2439..2512	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910