DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and CPEB4

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_085130.2	Gene:	CPEB4 / 80315	HGNCID:	21747	Length:	729	Species:	Homo sapiens

Alignment Length:	775	Identity:	332/775 - (42%)
Similarity:	409/775 - (52%)	Gaps:	163/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSATSSASGSNSNLSGSTSASASAATSPTSSGTAVGGILSGAPKSPPGLGSSTPISVRFNANEES 74
            |:..|.|:..|:|.:.:.|::.||...|..:...:...:.|:.|:              .:.::.
Human    36 NATPSPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKA--------------KSQQQE 86

  Fly    75 LDDILQSFHHSKHSPSGGASGG--------------GDASPTSN------------LLG---MKN 110
            ..|.|:.   .:.|||.|...|              ||.|..:.            |.|   .:.
Human    87 QQDPLEK---QQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRIESPVLTGFDYQEA 148

  Fly   111 NGLGL----VVGNCDSLSSSPSQPQMHAGSASLFGNDEVSLRNNFMQAGGFFNRKSCGGLPNLNL 171
            .|||.    :..:..||:...:.....|.|:|...|::.|          ||::   ||:|..:.
Human   149 TGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDAS----------FFHQ---GGVPAASA 200

  Fly   172 NK--------------------PPQLHQQQHQQQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHH 216
            |.                    .||:........|..|.||...|...|.:...||:.....|.:
Human   201 NNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRN 265

  Fly   217 QQQQQLRESGGS-----------HSPS-------SPGGGG----GGSPYNGSQAGCSSGGISPIP 259
            ....||.....:           .|||       ||||||    |||.....:.|. :|||:|:
Human   266 AAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGGSQGRDHRRGL-NGGITPL- 328

  Fly   260 PQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLSIGNGGGGGSTGMVSAGATGG 324
                      .||| |:|.|             ..|.|:.:...:..:......:.|..:.....
Human   329 ----------NSIS-PLKKN-------------FASNHIQLQKYARPSSAFAPKSWMEDSLNRAD 369

  Fly   325 GDAPYLGNSYGNMMTSNGQMHHGGGLDNSLCDYMR--NMSLGG--NGGGDGSNSMSLMQDRM--R 383
            ...|:...      .....||   .|::||.|.||  |.::.|  |....||:|..|:..|.  |
Human   370 NIFPFPDR------PRTFDMH---SLESSLIDIMRAENDTIKGRLNYSYPGSDSSLLINARTYGR 425

  Fly   384 VMGGPKHLSEADAMAIAASGNDPSVYLNALKMGSPSRLSPHSPHSPIQGGNGGNVGDGTARFSRK 448
            ..|........|.......|:.|   |:: .:|||...|..:             |:...|:|||
Human   426 RRGQSSLFPMEDGFLDDGRGDQP---LHS-GLGSPHCFSHQN-------------GERVERYSRK 473

  Fly   449 VFVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDESSVQQLIDSCITD 513
            ||||||||||||||||.||||||||:||||||||||||||||||||||||||||||.|||:||.:
Human   474 VFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACIEE 538

  Fly   514 EDKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVGGVPRPLKAFELAMIMDRL 578
            :.||||||||||||||.||||||.|:|:|:|:|.:..||||||:|||||||||:|.|||||||||
Human   539 DGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRL 603

  Fly   579 YGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCD 643
            ||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||:||
Human   604 YGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCD 668

  Fly   644 ECEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGREYHKPLVKEGADRPRAVPFRW 703
            ||:|.||||||||||||||||||||||:|||.||||.|||:||||||||.||||.:.|||
Human   669 ECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRW 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	81/90 (90%)
		RRM2_CPEB2_like	555..635	CDD:241170	75/79 (95%)
		CEBP_ZZ	630..691	CDD:318563	53/60 (88%)
CPEB4	NP_085130.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..49		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..328		29/110 (26%)
		RRM1_CPEB2_like	472..563	CDD:410123	81/90 (90%)
		RNA-binding. /evidence=ECO:0007744\|PDB:5DIF	541..543		1/1 (100%)
		RRM2_CPEB2_like	580..660	CDD:410125	75/79 (95%)
		CEBP_ZZ	655..716	CDD:406704	53/60 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140712
Domainoid	1	1.000	173	1.000	Domainoid score	I3695
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm41783
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.680