DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and Cpeb4

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_080528.2	Gene:	Cpeb4 / 67579	MGIID:	1914829	Length:	729	Species:	Mus musculus

Alignment Length:	793	Identity:	334/793 - (42%)
Similarity:	409/793 - (51%)	Gaps:	199/793 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSATSSASGSNSNLSGSTSASASAATSPTSSGTAVGGILSGAPKSPPGLGSSTPISVRFNANEES 74
            |:..:.|:..|:|.:.:.|::.||...|..:...:...:.|:.|:              .:.::.
Mouse    36 NATPNPAAFINNNTAANGSSAGSAWLFPAPATHNIQDEILGSEKA--------------KSQQQE 86

  Fly    75 LDDILQSFHHSKHSPSGGASGG--------------GDASPTSN------------LLG---MKN 110
            ..|.|:.   .:.|||.|...|              ||:|..::            |.|   .:.
Mouse    87 QQDPLEK---QQLSPSPGQEAGILPETEKAKAEENPGDSSSENSNGKEKLRIESPVLTGFDYQEA 148

  Fly   111 NGLGL----VVGNCDSLSSSPSQPQMHAGSASLFGNDEVSLRNNFMQAGGFFNRKSCGGLPNLNL 171
            .|||.    :..:..||:...:.....|.|:|...|::.|          ||::   ||:|..:.
Mouse   149 TGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDAS----------FFHQ---GGVPGASA 200

  Fly   172 NKPPQLHQQ-QHQ----------------QQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQQQ 219
            |....|.|. .|.                .||..|..|.|                  |||.|.|
Mouse   201 NNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQ------------------HHHSQHQ 247

  Fly   220 QQLRESGGSH--------------------------------SPS-------SPGGGG----GGS 241
            ||.|.....|                                |||       ||||||    |.|
Mouse   248 QQRRSPASPHPPPFTHRSAAFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGGGYGGWGAS 312

  Fly   242 PYNGSQAGCSSGGISPIPPQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLSIG 306
            .....:.|. :|||:|:           .||| |:|.|             ..|.|:.:...:..
Mouse   313 QGRDHRRGL-NGGITPL-----------NSIS-PLKKN-------------FASNHIQLQKYARP 351

  Fly   307 NGGGGGSTGMVSAGATGGGDAPYLGNSYGNMMTSNGQMHHGGGLDNSLCDYMR--NMSLGG--NG 367
            :......:.|..:........|:      ........||   .|::||.|.||  |.|:.|  |.
Mouse   352 SSAFAPKSWMEDSLNRADNIFPF------PERPRTFDMH---SLESSLIDIMRAENDSIKGRLNY 407

  Fly   368 GGDGSNSMSLMQDRM--RVMGGPKHLSEADAMAIAASGNDPSVYLNALKMGSPSRLSPHSPHSPI 430
            ...||:|..|:..|.  |..|........|.......|:.|   |:: .:|||...:..:
Mouse   408 SYPGSDSSLLINARTYGRRRGQSSLFPMEDGFLDDGRGDQP---LHS-GLGSPHCFTHQN----- 463

  Fly   431 QGGNGGNVGDGTARFSRKVFVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYFPPKGYAFL 495
                    |:...|:|||||||||||||||||||.||||||||:|||||||||||||||||||||
Mouse   464 --------GERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFL 520

  Fly   496 LFQDESSVQQLIDSCITDEDKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVG 560
            |||||||||.|||:||.::.||||||||||||||.||||||.|:|:|:|:|.:..||||||:|||
Mouse   521 LFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVG 585

  Fly   561 GVPRPLKAFELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGD 625
            ||||||:|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   586 GVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGE 650

  Fly   626 IDKRVEVKPYVLDDQMCDECEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGREYHKPLVK 690
            |||||||||||||||:||||:|.||||||||||||||||||||||:|||.||||.|||:||||||
Mouse   651 IDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVK 715

  Fly   691 EGADRPRAVPFRW 703
            ||.||||.:.|||
Mouse   716 EGGDRPRHISFRW 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	81/90 (90%)
		RRM2_CPEB2_like	555..635	CDD:241170	75/79 (95%)
		CEBP_ZZ	630..691	CDD:318563	53/60 (88%)
Cpeb4	NP_080528.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..50		4/13 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..324		26/124 (21%)
		RRM1_CPEB2_like	472..563	CDD:241168	81/90 (90%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q17RY0	541..543		1/1 (100%)
		RRM2_CPEB2_like	580..660	CDD:241170	75/79 (95%)
		CEBP_ZZ	655..716	CDD:374504	53/60 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830682
Domainoid	1	1.000	173	1.000	Domainoid score	I3673
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	526	1.000	Inparanoid score	I1228
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm43834
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.680