DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and cpeb4a

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_005173170.2	Gene:	cpeb4a / 393956	ZFINID:	ZDB-GENE-040426-1557	Length:	711	Species:	Danio rerio

Alignment Length:	767	Identity:	334/767 - (43%)
Similarity:	402/767 - (52%)	Gaps:	180/767 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGSNSNLSGST-SASASAATSPTSS--GTAVGGILSGAPK--------------SPPGLGSSTPI 64
            |.:|:...||. ||....|.:|.|:  ...:...:|.||:              ||||......|
Zfish    44 SNNNTTNGGSVGSAWLFPAVTPHSNMQDDILESEMSKAPQLQQESQEGQDKQTLSPPGHQEPPGI 108

  Fly    65 SVRFNANEESLDDILQSFHHSKHSPSGGASGGGDASPTSNLLG----MKNNGLGLVVGNCDSLSS 125
            .       ..||:.|...:..:......|:|.......|.:|.    .:..|:|.:..:  |.||
Zfish   109 I-------SELDNALPEENQLEKGTMENANGKETLRLESPVLSGFDYQETTGIGTLAQS--SSSS 164

  Fly   126 SPSQPQMHAGSASLFGNDEVSLRNNFMQAGGFFNRKSCGGLPNLNLNKPPQL------------- 177
            |.|.....:.|.::..|.     :..::..||||:.:...      |.||.|
Zfish   165 SSSLTGFSSWSTAMPPNP-----STLIEEVGFFNQAATTN------NAPPPLLFQSFSHHTSTGF 218

  Fly   178 -----HQ----QQHQQQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQQQQQLRESG------- 226
                 ||    .||......|.||...|   ..:...||:.....|......||...|
Zfish   219 GGNFSHQIGPLSQHHPSPHPHFQHPHNQ---HRRSSASPHPPPFSHRSAAFNQLPHLGNNLSKPP 280

  Fly   227 ---GSH-SPS--------SPGGGGGGSPYNGSQAG--CSSGGISPIPPQMGVSPKYRRSISFPIK 277
               ||: |||        |||||.||.   ||..|  ...||::|:   ..:||..:   |||
Zfish   281 SPWGSYQSPSSTPSSTSWSPGGGYGGW---GSSQGREYRRGGVNPL---NSISPLKK---SFP-- 334

  Fly   278 GNSPTAIYGNMHMDGMGSGHMNIPTLSIGNGGGGGSTGMVSAGATGGGDAPYLGNSYG------- 335
             |:.|                              .|.......:|....|::.::..
Zfish   335 -NNQT------------------------------QTQKYPRNNSGFNTKPWMEDTINRNESIFP 368

  Fly   336 ---NMMTSNG-QMHHGGGLDNSLCDYMR----NMSLGGNGGGDGSNSMSLMQDRMRVMGGPKHLS 392
               ...:.:| .||   .|:|||.|.||    ::.....|...|.:|:..|:|.       :...
Zfish   369 FQERSRSFDGFSMH---SLENSLIDIMRAEQDSLKARNYGRRRGHSSLFPMEDE-------RSYG 423

  Fly   393 EADAMAIAASGNDPSVYLNALKMGSPSRLSPHS-PHSPIQGGNGGNVGDGTARFSRKVFVGGLPP 456
            |.:....:.||           :|     |||| ||.     ||..:    .|:|||||||||||
Zfish   424 EDERSDQSLSG-----------LG-----SPHSFPHQ-----NGERI----ERYSRKVFVGGLPP 463

  Fly   457 DIDEDEITTSFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDESSVQQLIDSCITDEDKLYLCV 521
            ||||||||.||||||.|.||||||||||||||||||||||||||||||.|||:|:.::.||||||
Zfish   464 DIDEDEITASFRRFGHLFVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACMEEDGKLYLCV 528

  Fly   522 SSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVGGVPRPLKAFELAMIMDRLYGGVCYAG 586
            ||||||||.||||||.|.|:|:|:|.:..||||||:|||||||||:|.|||||||||||||||||
Zfish   529 SSPTIKDKPVQIRPWNLNDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAG 593

  Fly   587 IDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECEGQRCG 651
            ||||||||||||||||||||||||||||||||||||||:|||||||||||||||:||||:|.|||
Zfish   594 IDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDECQGTRCG 658

  Fly   652 GKFAPFFCANVTCLQYYCEHCWAVIHSRPGREYHKPLVKEGADRPRAVPFRW 703
            |||||||||||||||||||:|||.||||.|||:||||||||.||||.:.|||
Zfish   659 GKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVKEGGDRPRHISFRW 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	79/90 (88%)
		RRM2_CPEB2_like	555..635	CDD:241170	75/79 (95%)
		CEBP_ZZ	630..691	CDD:318563	53/60 (88%)
cpeb4a	XP_005173170.2	RRM	333..616	CDD:223796	174/350 (50%)
		RRM1_CPEB2_like	454..545	CDD:241168	79/90 (88%)
		RRM2_CPEB2_like	562..642	CDD:241170	75/79 (95%)
		CEBP_ZZ	637..698	CDD:292976	53/60 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573423
Domainoid	1	1.000	172	1.000	Domainoid score	I3671
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1338
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm25720
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.680