DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and cpb-1

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_499051.3	Gene:	cpb-1 / 176310	WormBaseID:	WBGene00000770	Length:	560	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	191/571 - (33%)
Similarity:	267/571 - (46%)	Gaps:	135/571 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 QQQLSPN----LSA---LHHHHQQQQQLRESGGSHSPSSPGGGGGGSPYNGSQAGCSSGGISPIP 259
            |.||||:    .||   ..|.|::..:.::|||.           |:||           :|...
Worm     2 QYQLSPSGDFKTSAPVRSSHGHRRSTESKKSGGH-----------GNPY-----------LSTDK 44

  Fly   260 PQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLSIGNGGGGGSTGMVSAGATGG 324
            ..:.:|..:..|             .....|.||.:.|           |....|.|::|.....
Worm    45 TNLDISVSFLTS-------------QAQKKMRGMSANH-----------GIFDPTEMLTADDPSN 85

  Fly   325 GDAPYLGNS--YGNM-------------MTSNGQMHHGGGLDNSLCDYMRNMSLGGNGGGDGSNS 374
            ....:|.::  |.||             |:.|.........|.|....|...:...|...:.|.|
Worm    86 YGYQFLNHATFYNNMDIMQAASGDVPPLMSVNPYKQSFDINDASAAMNMAQFAHTLNAIQNSSYS 150

  Fly   375 MS-----LMQ--------------------------DRM---RVMGGPKHLSEADAMAIAASGND 405
            ||     .||                          :||   :.:.|.:::...|..|::|
Worm   151 MSHYNQAPMQHFISPNSFHVSYNQRFPHIKKNATHANRMVEIKKINGHRYMEVTDPQAVSA---- 211

  Fly   406 PSVY--LNALKMGSPSRLSPHSPHSPIQGGNGGNVGDGTARFSRKVFVGGLPPDIDEDEITTSFR 468
            |..|  |:...||........|...||         .....:|||||:||||.|:.|:::..:|.
Worm   212 PPEYKRLDGSLMGVSKSCLEASKKRPI---------SAEPLYSRKVFIGGLPIDVSEEQVWATFG 267

  Fly   469 RFGPLVVDWP----HKAESKSYFPPK--------GYAFLLFQDESSVQQLIDSCITDEDKLYLCV 521
            .||.:::|||    |.||.......|        ||.||:|..|.|||:|:::|...|||.||.:
Worm   268 AFGKVLIDWPRRPEHNAERAEQELKKGSGSRAVTGYVFLVFTHERSVQELVNACEFYEDKYYLQL 332

  Fly   522 SSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVGGVPRPLKAFELAMIMDRLYGGVCYAG 586
            ||||:.|||||:|||||:|.||..:...|:|.|:|||:||||||.:|.:||..::..||.|.|.|
Worm   333 SSPTMTDKAVQVRPWRLSDIDYFCNDNSSVDHRRTVFIGGVPRPTRAQDLARCLEGHYGKVSYVG 397

  Fly   587 IDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECEGQRCG 651
            ||.||||||||||.||.||..|:::.|||.||||:.|.:.:||||:||||:::|.||||||:.|.
Worm   398 IDIDPELKYPKGAARVTFSTSQAFVRAISGRFVQVNHAENNKRVEIKPYVMEEQYCDECEGRLCK 462

  Fly   652 GKFAPFFCANVTCLQYYCEHCWAVIH-----SRPGREYHKPLVKEGADRPR 697
            ..:||:||.:.:|||||||.||..:|     .....:.|.|:|:.| |:.|
Worm   463 HNYAPYFCGHASCLQYYCEGCWDRMHIGKNEDNKLEDQHYPMVRTG-DQTR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	48/102 (47%)
		RRM2_CPEB2_like	555..635	CDD:241170	47/79 (59%)
		CEBP_ZZ	630..691	CDD:318563	31/65 (48%)
cpb-1	NP_499051.3	RRM	166..427	CDD:223796	107/273 (39%)
		RRM_SF	246..349	CDD:302621	48/102 (47%)
		RRM2_CPEB2_like	366..446	CDD:241170	47/79 (59%)
		CEBP_ZZ	441..507	CDD:292976	31/65 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166677
Domainoid	1	1.000	112	1.000	Domainoid score	I3896
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.928771	Normalized mean entropy	S3563
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		oto18851
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	1	1.100	-	-	O	PTHR12566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.720