DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and cpeb4

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_004912901.2	Gene:	cpeb4 / 100489114	XenbaseID:	XB-GENE-988741	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	801	Identity:	343/801 - (42%)
Similarity:	404/801 - (50%)	Gaps:	233/801 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SATSSASGSNSNLSGSTSASASAATSPTSSGTAVGGILSGAPKSPPGLGSSTPISVRFNANEESL 75
            :.|.|.:...:|.:.:.|.:.||...|..:...:...:.|:.||.         |.:....:|||
Frog    36 NTTPSPAAFINNTAANGSNAGSAWLFPAPAAHNIQDEILGSEKSK---------SQQQQEQQESL 91

  Fly    76 DDILQSFHHSKHSPSGGASGG--------------GDASPTSN------------LLG---MKNN 111
            :       ..:.|||.....|              ||:|..:.            |.|   .:.:
Frog    92 E-------KQQLSPSQSQEAGILPDPEKVKSEENQGDSSSENGNGKDKIRIESPVLTGFDYQEAS 149

  Fly   112 GLGLVVGNCDSLSSSPSQ-------PQMHAGSASLFGNDEVSLRNNFMQAGGFFNRKSCGGLPNL 169
            |||   .:..:|:||.|.       ....|.|:|...|::.|          ||::   ||:|..
Frog   150 GLG---SSNQTLTSSASPLTGFSNWSAAIAPSSSTMINEDAS----------FFHQ---GGVPAA 198

  Fly   170 NLNKPPQLHQQ-QHQ----------------QQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQ 217
            :.|....|.|. .|.                .||..|..|.|                  |||:|
Frog   199 SANNGALLFQNFPHHVSPGFGGSFSPQIGPLSQHHPHHPHFQ------------------HHHNQ 245

  Fly   218 QQQQLRESGGSH--------------------------------SPS-------SPGGGG----G 239
            .|||.|.....|                                |||       ||||.|    |
Frog   246 HQQQRRSPASPHPPPFTHRNAGFNQLPHLANNLNKPPSPWSSYQSPSPTPSSSWSPGGSGYGGWG 310

  Fly   240 GSPYNGSQAGCSSGGISPIPPQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLS 304
            ||.....:.|.:.|    :||...:|         |:|.|     :||.|:.....|..|
Frog   311 GSQGRDHRRGLNGG----MPPLNSIS---------PLKKN-----FGNNHIQLQKYGRPN----- 352

  Fly   305 IGNGGGGGSTGMVSAGATGGGDAPYLGNSYGNMM-----TSNGQMHHGGGLDNSLCDYMR--NMS 362
                         ||.|........| |...|:.     |....||   .|::||.|.||  |.|
Frog   353 -------------SAFAPKSWMDDSL-NRADNIFPFADRTRAFDMH---SLESSLIDIMRAENDS 400

  Fly   363 LGGN--GGGDGSNSMSLMQDRMRVMG---GPKHLSEADAMAIAASGNDPSVYLNALKMGSPSRLS 422
            |...  |...|.:|:..|:|.....|   .|.|           ||           :||| ...
Frog   401 LKARTYGRRRGQSSLFPMEDGFLDDGRSDQPLH-----------SG-----------LGSP-HCF 442

  Fly   423 PHSPHSPIQGGNGGNVGDGTARFSRKVFVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYF 487
            ||.        ||..|    .|:|||||||||||||||||||.||||||||:|||||||||||||
Frog   443 PHQ--------NGERV----ERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYF 495

  Fly   488 PPKGYAFLLFQDESSVQQLIDSCITDEDKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLD 552
            |||||||||||||||||.|||:||.::.||||||||||||||.||||||.|:|:|:|:|.:..||
Frog   496 PPKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLD 560

  Fly   553 PRKTVFVGGVPRPLKAFELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISAR 617
            ||||:|||||||||:|.||||||||||||||||||||||||||||||||||||||||||||||||
Frog   561 PRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISAR 625

  Fly   618 FVQLQHGDIDKRVEVKPYVLDDQMCDECEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGR 682
            |||||||:|||||||||||||||:||||:|.||.|||||||||||||||||||:|||.||||.||
Frog   626 FVQLQHGEIDKRVEVKPYVLDDQLCDECQGARCSGKFAPFFCANVTCLQYYCEYCWAAIHSRAGR 690

  Fly   683 EYHKPLVKEGADRPRAVPFRW 703
            |:||||||||.||||.:.|||
Frog   691 EFHKPLVKEGGDRPRHISFRW 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	81/90 (90%)
		RRM2_CPEB2_like	555..635	CDD:241170	75/79 (95%)
		CEBP_ZZ	630..691	CDD:318563	52/60 (87%)
cpeb4	XP_004912901.2	RRM1_CPEB2_like	455..546	CDD:410123	81/90 (90%)
		RRM2_CPEB2_like	563..643	CDD:410125	75/79 (95%)
		CEBP_ZZ	638..699	CDD:406704	52/60 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3646
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm49004
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4704
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.990