DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and cpeb4b

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001338642.1	Gene:	cpeb4b / 100333151	ZFINID:	ZDB-GENE-170601-167	Length:	726	Species:	Danio rerio

Alignment Length:	800	Identity:	351/800 - (43%)
Similarity:	406/800 - (50%)	Gaps:	216/800 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NSATSSASGSNSNLSGSTSASASAATSPTSSGTAVGG-------IL-SGAPK------------- 53
            |:..|.|:..||..:|:.|:|||....|     |.||       || |..||
Zfish    36 NATASPAAFINSTPAGNGSSSASTWLFP-----AAGGHNNMQDEILGSDKPKVQQQELQETQDKQ 95

  Fly    54 ----SPPGLGSSTPIS--VRFNANEESLDD-----------------ILQSFHHSKHSPSGGASG 95
                ..||...||.||  .:..|.|..::.                 :|.:|.:.:  |||  .|
Zfish    96 QQQQLSPGHQESTIISELEKARAEEGKVESGSSEGTNGKEKLRLESPVLTAFDYQE--PSG--LG 156

  Fly    96 GGDASPTSNLLGMKNNGLGLVVGNCDSLSSSPSQPQMHAGSASLFGNDEVSLRNNFMQAGGFFNR 160
            ....|.||:.|...||....:          |:.|.........|.|...|..|..:....|.:.
Zfish   157 TAAQSSTSSSLTSFNNWSAAI----------PATPSTIINEDISFFNPAASANNGPLLFQNFSHH 211

  Fly   161 KSCGGLPNLNLNKPPQL-----HQQQH---QQQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQ 217
            .|    |....|..||:     |...|   |..|.|||||:        :...||:.....|...
Zfish   212 VS----PGFGGNFSPQIGPISQHHPPHPHFQHPHSQHQQHR--------RSPASPHPPPFPHRSA 264

  Fly   218 QQQQLRES-----------GGSHSPS--------SPGGGGGGSPYNGSQA-----GCSSGGISPI 258
            ...||...           |...|||        |||||.||  :.|||.     |. :||::|:
Zfish   265 PFGQLPHLSNNLSKPPSPWGSYQSPSPSPSSTSWSPGGGYGG--WGGSQGREYRRGL-NGGMTPL 326

  Fly   259 PPQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMGSGHMNIPTLSIGNGGGGGSTGMVSAGATG 323
                       .||| |:|...|     |.||...                      ..|..:.|
Zfish   327 -----------NSIS-PLKKTFP-----NNHMPQQ----------------------KYSRASPG 352

  Fly   324 GGDAPYLGNSYGNMMTSNGQ--------MHHGGGLDNSLCDYMR--NMSLGG-----NGGGD--- 370
            .....::.:...|:.....:        ||   .|:|||.|.||  ..:|.|     :.|||
Zfish   353 FNPKSWMDDRSENIFPFQDRPRSFDGFNMH---SLENSLIDIMRAEQDTLKGRLGFTHPGGDSPL 414

  Fly   371 -----------GSNSMSLMQDRMRVMGGPKHLSEADAMAIAASGNDPSVYLNALKMGSPSRLSPH 424
                       |.:|:..|:|     |.|.. ..||                   ...|...|||
Zfish   415 PINARNYGRRRGHSSLFPMED-----GFPDE-ERAD-------------------QSLPGLSSPH 454

  Fly   425 S-PHSPIQGGNGGNVGDGTARFSRKVFVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYFP 488
            . ||.     ||..|    .|:|||||||||||||||||||.||||||.|.||||||||||||||
Zfish   455 CFPHQ-----NGERV----ERYSRKVFVGGLPPDIDEDEITASFRRFGHLFVDWPHKAESKSYFP 510

  Fly   489 PKGYAFLLFQDESSVQQLIDSCITDEDKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLDP 553
            ||||||||||||||||.|||:||.::.||||||||||||||.||||||.|.|:|:|:|.:..|||
Zfish   511 PKGYAFLLFQDESSVQALIDACIEEDGKLYLCVSSPTIKDKPVQIRPWNLNDSDFVMDGSQPLDP 575

  Fly   554 RKTVFVGGVPRPLKAFELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARF 618
            |||:|||||||||:|.|||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   576 RKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARF 640

  Fly   619 VQLQHGDIDKRVEVKPYVLDDQMCDECEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGRE 683
            ||||||:|||||||||||||||:||||:|.||||||||||||||||||||||:|||.||||.|||
Zfish   641 VQLQHGEIDKRVEVKPYVLDDQLCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGRE 705

  Fly   684 YHKPLVKEGADRPRAVPFRW 703
            :||||||||.||||.:.|||
Zfish   706 FHKPLVKEGGDRPRHISFRW 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	80/90 (89%)
		RRM2_CPEB2_like	555..635	CDD:241170	75/79 (95%)
		CEBP_ZZ	630..691	CDD:318563	53/60 (88%)
cpeb4b	NP_001338642.1	RRM1_CPEB2_like	469..560	CDD:241168	80/90 (89%)
		RRM2_CPEB2_like	577..657	CDD:241170	75/79 (95%)
		CEBP_ZZ	652..713	CDD:318563	53/60 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573422
Domainoid	1	1.000	172	1.000	Domainoid score	I3671
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1338
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm25720
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790