DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb2 and cpeb2

DIOPT Version :9

Sequence 1:	NP_001356977.1	Gene:	orb2 / 39018	FlyBaseID:	FBgn0264307	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_002666445.2	Gene:	cpeb2 / 100330483	ZFINID:	ZDB-GENE-130530-639	Length:	728	Species:	Danio rerio

Alignment Length:	774	Identity:	335/774 - (43%)
Similarity:	399/774 - (51%)	Gaps:	185/774 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PKANSATSSASGSNSNLSGSTSA----------------------SASAATSPTSSGTAVGGILS 49
            |...:|:.|:|..:|..|.:..|                      |:|:::|.:||.|   |:.:
Zfish    62 PAGLTASQSSSEQSSRFSAAGHAQTAGDLQHDRNIHQQADPQPPYSSSSSSSSSSSST---GLDT 123

  Fly    50 GAPKSPPGLGSSTPISVRFNANEESLDDILQSFHHSKHSPSGGASGGGDASPTSNLLGMKNNGLG 114
            .||.|...:...:|.:...| |....:::|........:..||  |||.||||....|..
Zfish   124 DAPSSKVNIQMESPSAHHIN-NGTGANNMLAGAFPEMQNAGGG--GGGSASPTLPAFGTP----- 180

  Fly   115 LVVGNCDSLSSSPSQPQMHAGSASLFGNDEVSLRNNFMQAG-------GFFNRKSCGGLP----- 167
                 ....:|||..|.  :.||:.......:...:....|       |||...|....|
Zfish   181 -----WSVQTSSPPPPV--SNSANAINPIPATTEPDTYYPGIPSSINPGFFQSFSANPCPVQGFS 238

  Fly   168 ---NLNLNKPPQLHQQQHQQQHQQHQQHQQQQQLHQHQQQLSPNLSALHHHHQQQQQLRESGGSH 229
               :..:|.|||  .|..:.........|||....||:..        ::|||...:
Zfish   239 SPFSPQINVPPQ--PQSRRSPVSPQIPPQQQGAFLQHRNN--------YNHHQPMMK-------- 285

  Fly   230 SPSSPGGGGGGSPYNGSQAGCSSGGISPIPPQMGVSPKYRRSISFPIKGNSPTAIYGNMHMDGMG 294
              .||.|...||.:|       |||:|                            :|..|..|
Zfish   286 --QSPWGSHQGSGWN-------SGGMS----------------------------WGRDHRRG-- 311

  Fly   295 SGHMNIPTLSIGNGGGGGSTGMV-------SAGATGGGDAPYLGNSYG-------NMM-TSNG-- 342
             |.|.:|          ||...:       |:........|....|.|       ||. |.|.
Zfish   312 -GGMGVP----------GSINQISPMKKPFSSNVIAPPKFPRSAGSLGPKSWIEENMFRTDNNSN 365

  Fly   343 ---------------QMHHGGGLDNSLCDYMR--NMSLGGNGGGDGSNSMSLMQDRMRVMGGPKH 390
                           .||   .|::||.|.||  ...|.|:.|.....:..|:....|..|..:.
Zfish   366 TLLPLQDRSRMYDSLNMH---SLESSLIDIMRAEQDPLKGHVGCPHPGADGLLMLNARSYGRRRG 427

  Fly   391 LSEA----DAMAIAASGNDPSVYLNALKMGSPSRL-SPHS-PHSPIQGGNGGNVGDGTARFSRKV 449
            .|..    |.:.....||          .|.|..| |||. ||.     ||..:    .||||||
Zfish   428 RSSLFPIDDGLLDDGHGN----------QGVPGVLGSPHCYPHQ-----NGERI----ERFSRKV 473

  Fly   450 FVGGLPPDIDEDEITTSFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQDESSVQQLIDSCITDE 514
            |||||||||||||||:||||||.||||||||||||||||||||||||||:|:|||.||::|:.::
Zfish   474 FVGGLPPDIDEDEITSSFRRFGHLVVDWPHKAESKSYFPPKGYAFLLFQEETSVQALIEACLEED 538

  Fly   515 DKLYLCVSSPTIKDKAVQIRPWRLADADYVLDATMSLDPRKTVFVGGVPRPLKAFELAMIMDRLY 579
            .||||||||||||||.||||||.|:|:|:|:|.:..||||||:|||||||||:|.||||||||||
Zfish   539 GKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLY 603

  Fly   580 GGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDE 644
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Zfish   604 GGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQLCDE 668

  Fly   645 CEGQRCGGKFAPFFCANVTCLQYYCEHCWAVIHSRPGREYHKPLVKEGADRPRAVPFRW 703
            |:|.||||||||||||||||||||||.|||.||||.|||:|||||||||||||.:.|||
Zfish   669 CQGARCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVKEGADRPRQIHFRW 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb2	NP_001356977.1	RRM1_CPEB2_like	447..538	CDD:241168	77/90 (86%)
		RRM2_CPEB2_like	555..635	CDD:241170	76/79 (96%)
		CEBP_ZZ	630..691	CDD:318563	53/60 (88%)
cpeb2	XP_002666445.2	RRM	<467..633	CDD:223796	139/165 (84%)
		RRM1_CPEB2_like	471..562	CDD:241168	77/90 (86%)
		RRM2_CPEB2_like	579..659	CDD:241170	76/79 (96%)
		CEBP_ZZ	654..715	CDD:292976	53/60 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3671
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1338
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001410
OrthoInspector	1	1.000	-	-		otm25720
orthoMCL	1	0.900	-	-		OOG6_103884
Panther	1	1.100	-	-	LDO	PTHR12566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X879
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.960