Protein Alignment Tsp66E and CD37

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: XP_005259492.1
• Gene: CD37 / 951
• HGNCID: 1666
• Length: 365
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 70/272 - (25%)
• Similarity: 122/272 - (44%)
• Gaps: 44/272 - (16%)

  Fly    11 KYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVIGA 75
            ||.|.:||..|||||::||..|:|:.:||.|.::.:.|.       |...|...:   ||.:.|.
Human    12 KYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLA-------FVPLQIWSK---VLAISGI 66

  Fly    76 VMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITSYS 140
            ....::.||.:||::|.||||..|...|:||...:|..|.|.:..:.::....::.::.||..|.
Human    67 FTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYG 131

  Fly   141 LGENVDATSLMWNQLMGNFGCCGINDYHDFDASPAWV-------NGKGNRTIPDAC--------- 189
            ......|....|:.:.....|||.:...|      |.       ||.....:|.:|
Human   132 TNPEETAAEESWDYVQFQLRCCGWHYPQD------WFQVLILRGNGSEAHRVPCSCYNLSATNDS 190

  Fly   190 -----CILKDVAKL--VPRDE---DCTTNPSDSNSFYKKGCYEVFTEWLIRQR-ELVIVAIAVGI 243
                 .||..:::|  :.|..   |....|::|: .|::||.:...:||.... .:|.:.:.||:
Human   191 TILDKVILPQLSRLGHLARSRHSADICAVPAESH-IYREGCAQGLQKWLHNNLISIVGICLGVGL 254

  Fly   244 VHLVLIILAFAL 255
            :.:.:::|:..|
Human   255 LEMTVMVLSVQL 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	70/272 (26%)
		tetraspanin_LEL	120..228	CDD:351888	24/133 (18%)
CD37	XP_005259492.1	Tetraspanin	26..266	CDD:459767	60/256 (23%)
		CD37_CD82_like_LEL	108..243	CDD:239413	26/141 (18%)