Protein Alignment Tsp66E and TSPAN18

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: XP_005253274.1
• Gene: TSPAN18 / 90139
• HGNCID: 20660
• Length: 258
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 80/266 - (30%)
• Similarity: 137/266 - (51%)
• Gaps: 40/266 - (15%)

  Fly     4 DCGVWCAKYLLCIFNFIFFVLGTIIFGVGLWLAVDK---HSLIALLKLVESERIEQFTQPQAIEQ 65
            || :.|.|||:.:|||..|:.|..:..:|:|:.||.   ..::|...|:.:.
Human    14 DC-LSCMKYLMFVFNFFIFLGGACLLAIGIWVMVDPTGFREIVAANPLLLTG------------- 64

  Fly    66 LAYVLLVIGAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKN 130
             ||:||.:|.::|.:.|||..||:||::|||..:..|::::.:||:.|..|...|::.:   ::.
Human    65 -AYILLAMGGLLFLLGFLGCCGAVRENKCLLLFFFLFILIIFLAELSAAILAFIFRENL---TRE 125

  Fly   131 FLQTTITSYSLGEN-VDATSLMWNQLMGNFGCCGINDYHDFD-ASPAWVNGKGNRTIPDACCILK 193
            |....:|.:..|.| .|..|..||.:|..|||||:|...||. ||...:....:..:|:|||..:
Human   126 FFTKELTKHYQGNNDTDVFSATWNSVMITFGCCGVNGPEDFKFASVFRLLTLDSEEVPEACCRRE 190

  Fly   194 DVAK---LVPRDEDCTTNPSDSNSFY--KKGCYEVFTEWLIRQRELVIV---AIAVGIVHLVLII 250
            ..::   |:.| |:|..    ..|.:  |:|||.|    ::...|..:.   |:|:|::.:.|..
Human   191 PQSRDGVLLSR-EECLL----GRSLFLNKQGCYTV----ILNTFETYVYLAGALAIGVLAIELFA 246

  Fly   251 LAFALC 256
            :.||:|
Human   247 MIFAMC 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	77/259 (30%)
		tetraspanin_LEL	120..228	CDD:351888	34/114 (30%)
TSPAN18	XP_005253274.1	Tetraspanin	20..255	CDD:459767	77/259 (30%)
		uroplakin_I_like_LEL	115..228	CDD:239409	35/124 (28%)