Protein Alignment Tsp66E and Tspan12

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_001015026.1
• Gene: Tspan12 / 362326
• RGDID: 1311102
• Length: 305
• Species: Rattus norvegicus
• Alignment Length: 276
• Identity: 62/276 - (22%)
• Similarity: 120/276 - (43%)
• Gaps: 33/276 - (11%)

  Fly     1 MVFDCGVWCAKYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQ 65
            |..:..|.|.:.||...|.:|:::...:..|..|:   :..|..:|.|....|:|:.........
  Rat     1 MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWM---RDYLNNVLTLTAETRVEEAVILTYFPV 62

  Fly    66 LAYVLLVIGAVMFFMSFLGYLGAMRESRCLLSTY-GTFLILLLIAEIVAGGLGAFFKD---KVRA 126
            :..|::.:...:..:..|||.|.::.:..||:.| ||.|::..:.  :|.|:..:.::   .|:.
  Rat    63 VHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLVIFCVE--LACGVWTYEQEVMVPVQW 125

  Fly   127 ESKNFLQTTITSYSLGENVDATSLMWNQLMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDACCI 191
            .....|:..:|:|.|......|. .||.....|.|||:..:.|      |:........||:||:
  Rat   126 SDMVTLKARMTNYGLPRYRWLTH-AWNYFQREFKCCGVVYFTD------WLEMTEMDWPPDSCCV 183

  Fly   192 LKDVAKLVPRD-EDCT--TNPSDSNSFYKKGCYEVFTEWLIRQRELVI---VAIAVGIVHLVLII 250
                     |: ..|:  .:..|.:..|::||.:....:|...::|.:   :.|::|:..::.:|
  Rat   184 ---------REFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMI 239

  Fly   251 LAFALCKAFAKYNDMR 266
            |...|  .:|.|.|.|
  Rat   240 LTITL--LWALYYDRR 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	55/255 (22%)
		tetraspanin_LEL	120..228	CDD:351888	24/113 (21%)
Tspan12	NP_001015026.1	Tetraspanin	10..246	CDD:459767	55/258 (21%)
		TM4SF12_like_LEL	116..218	CDD:239410	25/117 (21%)