Protein Alignment Tsp66E and TSPAN33

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_848657.1
• Gene: TSPAN33 / 340348
• HGNCID: 28743
• Length: 283
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 70/263 - (26%)
• Similarity: 120/263 - (45%)
• Gaps: 49/263 - (18%)

  Fly    11 KYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVIGA 75
            ||||..||.:|:|:..::..||::..:.||:..||..|             |::. |.:|:|:|.
Human    23 KYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACL-------------AVDP-AILLIVVGV 73

  Fly    76 VMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITSYS 140
            :||.::|.|.:|::||:.|||.|:...|..:.:.::.||.||..|.||.|.:....:...|..|.
Human    74 LMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYR 138

  Fly   141 LGENVDATSLM-WNQLMGNFGCCGINDYHDFDASPAWVNGKGNR-----TIPDACCILKDVAKLV 199
              :::|..:|: :.|  ..|.|||...|.|:..:..:...:.|.     ::|.:||:
Human   139 --DDLDLQNLIDFGQ--KKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCL-------- 191

  Fly   200 PRDEDCTTNP------------SDSNSFYKKGCYEVFTEWLIRQRELVI---VAIAVGIVHLVLI 249
            |..:....|.            ..|...|..||.:....|:  ...|.:   ||:.:.|..||.|
Human   192 PTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWI--HSNLFLLGGVALGLAIPQLVGI 254

  Fly   250 ILA 252
            :|:
Human   255 LLS 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	70/263 (27%)
		tetraspanin_LEL	120..228	CDD:351888	25/125 (20%)
TSPAN33	NP_848657.1	Tetraspanin	22..262	CDD:459767	70/263 (27%)
		penumbra_like_LEL	116..236	CDD:239411	26/133 (20%)