Protein Alignment Tsp66E and TSPAN17

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_001353420.1
• Gene: TSPAN17 / 26262
• HGNCID: 13594
• Length: 355
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 76/312 - (24%)
• Similarity: 129/312 - (41%)
• Gaps: 82/312 - (26%)

  Fly     9 CAKYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVI 73
            |.||.|..||.:|:|||.:...:|||...:|..|..:..|.:...::.          .::.:|:
Human    16 CGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDP----------VWLFVVV 70

  Fly    74 GAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITS 138
            |.||..:.|.|.:||:||:..||..:..||.|:...|:..|.|...|||.:|.:...|:...:.:
Human    71 GGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKA 135

  Fly   139 YSLGENVDATSLM------WNQLMGNFGCCGINDYHDF---------DASPAWVNGKGNRTIPDA 188
            |.  :::|..:|:      |:       |||....:|:         |.:|:    :....:|.:
Human   136 YR--DDIDLQNLIDFAQEYWS-------CCGARGPNDWNLNIYFNCTDLNPS----RERCGVPFS 187

  Fly   189 CCILKDVAKLVPR-----DEDCTTNPSDSNSFYKKGCYEVFTEWLIRQRELVIVA-IAVGIV--- 244
            ||: :|.|:.|..     |.............:.|||...|.:||  |..|::|| :.:||.
Human   188 CCV-RDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWL--QDNLIVVAGVFMGIALLQ 249

  Fly   245 -------------------HLVLIILAFALCKA-------------FAKYND 264
                               ||..::..|.:|.|             ::|:||
Human   250 VPLWPHVPLPLPGPPSLSPHLSSVLQIFGICLAQNLVSDIKAVKANWSKWND 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	70/288 (24%)
		tetraspanin_LEL	120..228	CDD:351888	26/127 (20%)
TSPAN17	NP_001353420.1	Tetraspanin	18..>157	CDD:459767	43/157 (27%)
		TM4SF9_like_LEL	115..235	CDD:239412	29/135 (21%)