Protein Alignment Tsp66E and TSPAN3

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_005715.1
• Gene: TSPAN3 / 10099
• HGNCID: 17752
• Length: 253
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 65/260 - (25%)
• Similarity: 118/260 - (45%)
• Gaps: 53/260 - (20%)

  Fly     5 CGVWCAKYLLCIFNFIFFVLGTIIFGVGLWLAV----------DKHSLIALLKLVESERIEQFTQ 59
            ||:..:|.:|...|.||:....|:..||.::.:          |.::||.
Human     4 CGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIP--------------- 53

  Fly    60 PQAIEQLAYVLLVIGAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKV 124
                   |.|::.:||::|.:..:|....:|||||.|:|:...|:|:.:.|:|...||..::.||
Human    54 -------AVVIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKV 111

  Fly   125 RAESKNFLQTTITSYSLGENVDATSLMWNQLMGNFGCCGINDYHDFDASPAWVNGKGNRTIPDAC 189
            ..|....:|....:|: |.|.||.|...:.:.....||||::|.|:: :..|.....|:::|.:|
Human   112 ENEVDRSIQKVYKTYN-GTNPDAASRAIDYVQRQLHCCGIHNYSDWE-NTDWFKETKNQSVPLSC 174

  Fly   190 CILKDVAKLVPRDEDCTTNPSDSNSFYKKGCYEVFTEWLIRQRELVIVAIAVGIVHLVLIILAFA 254
            |  ::.|      .:|..:.:..:..|.:||           ..||:..:...::|::...||||
Human   175 C--RETA------SNCNGSLAHPSDLYAEGC-----------EALVVKKLQEIMMHVIWAALAFA 220

  Fly   255  254
            Human   221  220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	63/254 (25%)
		tetraspanin_LEL	120..228	CDD:351888	26/107 (24%)
TSPAN3	NP_005715.1	Tetraspanin	9..235	CDD:459767	63/255 (25%)
		TM4SF8_like_LEL	104..210	CDD:239416	29/126 (23%)