Protein Alignment Tsp66E and TSPAN5

DIOPT Version :10

• Sequence 1: NP_523985.1
• Gene: Tsp66E / 39017
• FlyBaseID: FBgn0035936
• Length: 267
• Species: Drosophila melanogaster
• Sequence 2: NP_005714.2
• Gene: TSPAN5 / 10098
• HGNCID: 17753
• Length: 268
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 82/269 - (30%)
• Similarity: 116/269 - (43%)
• Gaps: 47/269 - (17%)

  Fly     9 CAKYLLCIFNFIFFVLGTIIFGVGLWLAVDKHSLIALLKLVESERIEQFTQPQAIEQLAYVLLVI 73
            |.||.:..||.||:.||....|:|||...:|..|         ..|...|.....:.: ::.||:
Human    14 CIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVL---------SNISSITDLGGFDPV-WLFLVV 68

  Fly    74 GAVMFFMSFLGYLGAMRESRCLLSTYGTFLILLLIAEIVAGGLGAFFKDKVRAESKNFLQTTITS 138
            |.|||.:.|.|.:||:||:..||..:..||.::...|:.||.|...|||.::.:...|:...|.:
Human    69 GGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRA 133

  Fly   139 Y----SLGENVDATSLMWNQLMGNFGCCG--------INDYHDFDASPAWVNGKGNRT-IPDACC 190
            |    .|...:|.|...|.       |||        :|.|.:...|    |....|. :|.:||
Human   134 YRDDIDLQNLIDFTQEYWQ-------CCGAFGADDWNLNIYFNCTDS----NASRERCGVPFSCC 187

  Fly   191 ILKDVAKLVPRDE---DCTTNPSDSNS--FYKKGCYEVFTEWLIRQRELVIVA-IAVGIVHLVLI 249
             .||.|:.|...:   |....|.....  .|.|||...|.:||  |..|.||| |.:||.    :
Human   188 -TKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWL--QDNLTIVAGIFIGIA----L 245

  Fly   250 ILAFALCKA 258
            :..|.:|.|
Human   246 LQIFGICLA 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp66E	NP_523985.1	Tetraspanin	11..257	CDD:459767	79/264 (30%)
		tetraspanin_LEL	120..228	CDD:351888	32/125 (26%)
TSPAN5	NP_005714.2	Tetraspanin	15..258	CDD:459767	81/268 (30%)
		TM4SF9_like_LEL	113..233	CDD:239412	35/133 (26%)