DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mfr and Otof

DIOPT Version :10

Sequence 1:NP_001137919.1 Gene:mfr / 39016 FlyBaseID:FBgn0266757 Length:1647 Species:Drosophila melanogaster
Sequence 2:NP_114081.2 Gene:Otof / 83762 MGIID:1891247 Length:1997 Species:Mus musculus


Alignment Length:1893 Identity:460/1893 - (24%)
Similarity:793/1893 - (41%) Gaps:409/1893 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 AGAPQEFLICITVHKAAQ-VGVTTGELY-VRISLDKMTKSTKSFPNTENPFFNEYFVFEFHCTLT 71
            ||.|.::.:.|||.:|.| ||:....:. |.:..||...|.|.  :|..|::||||||:||    
Mouse   247 AGRPMDYQVSITVIEARQLVGLNMDPVVCVEVGDDKKYTSMKE--STNCPYYNEYFVFDFH---- 305

  Fly    72 ELLRLTILFE--LKKHMTYKKNV-----VVGELLVDLHSVWNQSNHGYFKKWGRLEAPIGENQTL 129
              :...::|:  :|..:.:.||:     :||...:|:.:|::|..|.:..||..|..|...:..|
Mouse   306 --VSPDVMFDKIIKISVIHSKNLLRSGTLVGSFKMDVGTVYSQPEHQFHHKWAILSDPDDISAGL 368

  Fly   130 ENAVAPHGYLQLDLAIVSQHSPVSYALGSEEQDTQNLNKWTVDHDFDDIEKNLLTNVNIFAPSNI 194
            :      ||::.|:|:|.:...:.....:.|.|.            ||||.|||      .|..:
Mouse   369 K------GYVKCDVAVVGKGDNIKTPHKANETDE------------DDIEGNLL------LPEGV 409

  Fly   195 -------RYFVAFYRGYFIKQSNY--------------------MIQVSFAGFNGKTPVVKNTTT 232
                   |::|..||...:.:.|.                    .:||.|||..|||.|.|::..
Mouse   410 PPERQWARFYVKIYRAEGLPRMNTSLMANVKKAFIGENKDLVDPYVQVFFAGQKGKTSVQKSSYE 474

  Fly   233 PVWNYEINFAWMYPSVAQRFLILIFAHEHLQWKCVAEFELCLEEIAFNG----TPSLGPTYLHLY 293
            |:||.::.|..::|.:.:|..:.|...:.:....:....:.|.:|:.:|    .|:|||.::::|
Mouse   475 PLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHFIDLRKISNDGDKGFLPTLGPAWVNMY 539

  Fly   294 ------------DPVNPMIYVG-----RLLMELRSEMLTDSQPTHTLS-----------SKTVPG 330
                        ..:|..:..|     ||::.|..|:|..|.|..|.|           |::..|
Mouse   540 GSTRNYTLLDEHQDLNEGLGEGVSFRARLMLGLAVEILDTSNPELTSSTEVQVEQATPVSESCTG 604

  Fly   331 LDETRFWHDDVYLIEFLPLMGHHILTSGTAYKISARLAEH--TSNVLEGQLRTPLDRFKSAMNSK 393
            ..|..|            |.|..:    .|..|..:..:.  |..|..|.....:|.....:..:
Mouse   605 RMEEFF------------LFGAFL----EASMIDRKNGDKPITFEVTIGNYGNEVDGMSRPLRPR 653

  Fly   394 NFRREAPFQSCMFRVRLPDNRAKYESDFFMLDIVNYMRSELDTFKLFQRKYPLQDDEQAKCLKV- 457
            ..:.....:.........|:......|...:.....||.::.....|...|.    |:..|:.: 
Mouse   654 PRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRNYFHLPYL----ERKPCIYIK 714

  Fly   458 --------------IVNNILTRIKEGLD---------------------------AHRF----DH 477
                          |:::|..:::|||:                           .|||    |.
Mouse   715 SWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVLEELSCGCHRFLSLSDK 779

  Fly   478 DV-QPQRTTWD------INRQLYLLDYFAK---LPLELQNLKQKLRSC--FLEHLDTSIGDVVNE 530
            |. :..||..|      ..|:|..:...||   ..::...::.|||||  ||:.|          
Mouse   780 DQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLRSCQNFLQKL---------- 834

  Fly   531 LQRLVAEIGSLSSMARTQDEWPELVLSLSASGKDVGVCRLNAK-LFLNLRNQDADQDQETLCWRL 594
              |.:|:        ..|...|::.:.:.::.|.:...|:.:| |..::..::..:|    |.::
Mouse   835 --RFLAD--------EPQHSIPDVFIWMMSNNKRIAYARVPSKDLLFSIVEEELGKD----CAKV 885

  Fly   595 KSFSFKSAGCSHTCPNCGCTT-AIVSGCLSIVVERERKRFLAVVNKEWANIE----------PML 648
            |:...|..| .....:.|.|. |.:...|.:.:.::||.||..:...:..::          |.:
Mouse   886 KTLFLKLPG-KRGFGSAGWTVQAKLELYLWLGLSKQRKDFLCGLPCGFEEVKAAQGLGLHSFPPI 949

  Fly   649 WQLNPEQTHFLCHVYIHQAKVRPGGEKKNICDSHLRVLFADQACETYTSPGTLSPIWNAVITFNW 713
            ..:..::..|....:::||:.....:...:.|...||.|.:|:..|.....||.|.|:.::.|:.
Mouse   950 SLVYTKKQAFQLRAHMYQARSLFAADSSGLSDPFARVFFINQSQCTEVLNETLCPTWDQMLVFDN 1014

  Fly   714 VSLPGGIGLYLKNPPLLSLEFYNSERSLPEDLVGMGSVAMSVISEDRASDSNWEDAGVFGCSKNP 778
            :.|.|.......:||::.:|.|:.:.....|.:|.                      .|.   .|
Mouse  1015 LELYGEAHELRDDPPIIVIEIYDQDSMGKADFMGR----------------------TFA---KP 1054

  Fly   779 LRKLQRLKYLT---PPPLKWVPIARKGTLQAEVLMSAEIIQISMESLTTGQNDKKEPQLATG--- 837
            |.|:....|..   ||.|::..|.|......::|.:.|::||       |.:.|.:.....|   
Mouse  1055 LVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELLQI-------GPSGKADLPPINGPVD 1112

  Fly   838 --------IPMAIRPTMQNFVLEVFFVGLRNYSKSSMSSAGKRKINLMMGDLVLSSGPSTARIRN 894
                    :|:.|||.:..:.:||.|.|||:..:.:::...:.::::...    ..|..::.|.|
Mouse  1113 MDRGPIMPVPVGIRPVLSKYRVEVLFWGLRDLKRVNLAQVDRPRVDIECA----GKGVQSSLIHN 1173

  Fly   895 -----SINFLVAYASGVVSLPDQQDYWPAIIATDVLLSGFSSESILGAALIPNSSNFLQR--DR- 951
                 :.|.||.:..  |.||:.:...|.:....|....|...:::|:..:.:...|:.|  || 
Mouse  1174 YKKNPNFNTLVKWFE--VDLPENELLHPPLNIRVVDCRAFGRYTLVGSHAVSSLRRFIYRPPDRS 1236

  Fly   952 --------------------------TLKCVFKKEQE--------------AAEASTTVSVDEDD 976
                                      |.:.|...|.|              .::|...|.|.||:
Mouse  1237 APNWNTTVRLLRGCHRLRNGGPSSRPTGEVVVSMEPEEPVKKLETMVKLDATSDAVVKVDVAEDE 1301

  Fly   977 EDEEEEL------EWEEEETKPSRISSWWMRLLFAFGLRPAPYANRHALRFHD----DLDDHELV 1031
            ::.:::.      |.||||...|.: .||.:...:..      ..:..||.|:    ||::.|.:
Mouse  1302 KERKKKKKKGPSEEPEEEEPDESML-DWWSKYFASID------TMKEQLRQHETSGTDLEEKEEM 1359

  Fly  1032 EEREFTWWTKFYNSMYWSAAEMCHEHKHR----------------------LVIYYEELEKQAQF 1074
            |..|.............:|.|   |.|.:                      |.:|.:|||  ::|
Mouse  1360 ESAEGLKGPMKSKEKSRAAKE---EKKKKNQSPGPGQGSEAPEKKKAKIDELKVYPKELE--SEF 1419

  Fly  1075 GYLQDWAVPVQLVHGVKFKKHGPPKEDIYATLKLQLKLTPCQCPVLEDPG--GGGDMVRNMSNPI 1137
            ...:||.....|:.|..........|:.....:.:..|...:.|:.||..  .|.|....|...|
Mouse  1420 DSFEDWLHTFNLLRGKTGDDEDGSTEEERIVGRFKGSLCVYKVPLPEDVSREAGYDPTYGMFQGI 1484

  Fly  1138 HPRHQSTLQSLGETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPV 1202
             |.:        :.:.:|||:|||:...:.|.|:.|.:|.|:.:.||.....|:.::.....|||
Mouse  1485 -PSN--------DPINVLVRIYVVRATDLHPADINGKADPYIAIKLGKTDIRDKENYISKQLNPV 1540

  Fly  1203 FGRLFEMEATLPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNH 1266
            ||:.|::||:.|.:.||.|.|||.|.: .|::||:|.||||:|:.::||||.|:|..|:..|||.
Mouse  1541 FGKSFDIEASFPMESMLTVAVYDWDLVGTDDLIGETKIDLENRFYSKHRATCGIAQTYSIHGYNI 1605

  Fly  1267 WHDVKLPSEILIDLCQKRGIQAPYY--YGNVIEVDGMLFGDETLISKDEELQ-----ERLSLAVL 1324
            |.|...||:||..||::..:..|::  :|.|...:.:..|...:  :||..|     |.::|:.|
Mouse  1606 WRDPMKPSQILTRLCKEGKVDGPHFGPHGRVRVANRVFTGPSEI--EDENGQRKPTDEHVALSAL 1668

  Fly  1325 KNMDKLPSFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVP-SPIDITPVPPADFE 1388
            ::.:.:|..|.:|||||||||.|...|.|.:|||:|:||:::|..::..| :|:||:|..|..:|
Mouse  1669 RHWEDIPRVGCRLVPEHVETRPLLNPDKPGIEQGRLELWVDMFPMDMPAPGTPLDISPRKPKKYE 1733

  Fly  1389 VRVVVKNLVGIQAGDKNIF-GKLMSDVYVIGWC--EDEDKRQSTDIHYRSFAGDAAFNWRMVFGL 1450
            :||:|.|...:...|.:.| |:..||::|.||.  :.||| |.||:||.|..|:..||||.:|..
Mouse  1734 LRVIVWNTDEVVLEDDDFFTGEKSSDIFVRGWLKGQQEDK-QDTDVHYHSLTGEGNFNWRYLFPF 1797

  Fly  1451 KYSPNEDLMVIRRKAGLL--EEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQ 1513
            .|...|:.:|:.:|..:.  :|.|:|.|..:.||:||.|..:.|::|.|:||:|:........|:
Mouse  1798 DYLAAEEKIVMSKKESMFSWDETEYKIPARLTLQIWDADHFSADDFLGAIELDLNRFPRGAKTAK 1862

  Fly  1514 LCK----------PYPKKRKRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDV 1568
            .|.          |.      :::||:|.:.||:||.:.    ..:......||::..:.:.|..
Mouse  1863 QCTMEMATGEVDVPL------VSIFKQKRVKGWWPLLAR----NENDEFELTGKVEAELHLLTAE 1917

  Fly  1569 EAVNRPAGRGQDPPMALEPPYRPDSSFNPLTHPCKSFQHILWPVIRKYVLWTLLILIVILGLVLF 1633
            ||...|.|..::.|..||.|.|||:||....:|.||.::.||...|..:|..||:.:::|...||
Mouse  1918 EAEKNPVGLARNEPDPLEKPNRPDTSFIWFLNPLKSARYFLWHTYRWLLLKFLLLFLLLLLFALF 1982

  Fly  1634 FSNLPAKL 1641
            ..:||..|
Mouse  1983 LYSLPGYL 1990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mfrNP_001137919.1 C2 12..122 CDD:472691 36/118 (31%)
C2 <213..293 CDD:472691 24/83 (29%)
C2D_Ferlin 658..818 CDD:175984 35/162 (22%)
C2E_Ferlin 1155..1277 CDD:176002 53/122 (43%)
C2F_Ferlin 1388..1517 CDD:176020 49/143 (34%)
Ferlin_C 1524..1619 CDD:435183 29/94 (31%)
OtofNP_114081.2 C2A_Ferlin 3..130 CDD:176019
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..167
C2B_Ferlin 250..361 CDD:175978 36/118 (31%)
FerI 359..409 CDD:462377 17/73 (23%)
C2C_Ferlin 417..566 CDD:175985 32/148 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..692 4/48 (8%)
FerB 841..916 CDD:462376 15/79 (19%)
C2D_Ferlin 959..1096 CDD:175984 34/161 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1253..1272 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1296..1326 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1343..1402 12/61 (20%)
C2E_Ferlin 1493..1616 CDD:176002 53/122 (43%)
C2F_Ferlin 1733..1866 CDD:176020 49/133 (37%)
Ferlin_C 1876..>1964 CDD:435183 29/97 (30%)
Blue background indicates that the domain is not in the aligned region.

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