Protein Alignment mfr and dysf

DIOPT Version :10

• Sequence 1: NP_001137919.1
• Gene: mfr / 39016
• FlyBaseID: FBgn0266757
• Length: 1647
• Species: Drosophila melanogaster
• Sequence 2: XP_031751122.1
• Gene: dysf / 100488564
• XenbaseID: XB-GENE-6076450
• Length: 2108
• Species: Xenopus tropicalis
• Alignment Length: 2021
• Identity: 471/2021 - (23%)
• Similarity: 781/2021 - (38%)
• Gaps: 515/2021 - (25%)

  Fly    12 PQEFLICITVHKAAQVGVTTGELYVRISLDKMTKSTKSFPNTENPFFNEYFVFEFHCTLTELLRL 76
            ||:|.:.:.|.:..|:.....:..|::::...||.|: .....||:|:|.|.|.|..:.:||...
 Frog   214 PQDFQVRVRVIEGRQIPGINIKPVVKVTVAGQTKRTR-IRKGNNPYFDETFFFNFFESPSELFDE 277

  Fly    77 TILFELKKHMTYKKNVVVGELLVDLHSVWNQSNHGYFKKWGRLEAPIGENQTLENAVAPHGYLQL 141
            .:...:....:.:.:.|:||..:|:..::.:|.|.:.:||..|..|.      :.:....|||::
 Frog   278 PVFLTVLDSRSLRTDSVIGEFRMDVGMIYGESKHAFLRKWLLLSDPD------DFSAGAKGYLKV 336

  Fly   142 DLAIVSQHSPVSYALGSEEQDTQNLNKWTVDHDFDDIEKNLLTNVNIFAPSNIRYFVAFYR---- 202
            .|          |.||  ..|...:.|..|..|.:|||.|||....: :.......:..||
 Frog   337 SL----------YVLG--PGDESPVEKKEVSEDKEDIEGNLLRPAGV-SLRGAHLTLKIYRAEDL 388

  Fly   203 ---------------GYFIKQSNYM---IQVSFAGFNGKTPVVKNTTTPVWNYEINFAWMYPSVA 249
                           |:...:.|.:   ::|||||....:.:::....|.|:..|.....:||:.
 Frog   389 PQMDDAVLDNVKQIFGFDSNKKNLVDPFVEVSFAGKMLLSKIMEKNANPQWSQSITLPIRFPSMC 453

  Fly   250 QRFLILIFAHEHLQW------KCVAEFELCLEEIA-------------------FNGT----PSL 285
            ::..|.:     |.|      ..:....|.:.:|:                   |:.|    |:.
 Frog   454 EKMRIRL-----LDWDRLTHNDIIGTTYLSMSKISAPGGEIEDETPRKALPVSNFDDTLGFLPTF 513

  Fly   286 GPTYLHLY----------DPVNPM--------IYVGRLLMELRSEMLTDSQPTHTLSSKTVPGLD 332
            ||.|::||          ||...:        .|.||:|:||.::::..::.    ..:.:|..|
 Frog   514 GPCYVNLYGSPREFTGFPDPYEDLNLGKGEGVAYRGRVLLELETKLVEQAEQ----KVEDIPSDD 574

  Fly   333 ETR---------------FWH-------DDVYLIEFLPLMGHH---------ILTSGTAY----- 361
            .:|               |:.       ||.  |:|...:|::         .|.|.|.|
 Frog   575 ISRVEKYLRRRKYCLFAAFYSATMLQDVDDA--IQFEVSIGNYGNKFDNTCLPLASTTQYSRAVF 637

  Fly   362 -------------KISARLAEH---------TSNVLE---GQLRTPLDRFKSAMNSKN------- 394
                         |....|:.|         |.|:|:   ..|...||....|:.:|:
 Frog   638 DGCQYYYLPWGNVKPVVVLSSHWEDIGHRTDTQNILQYAIDNLAANLDWVHLAVKAKSSPYDLDA 702

  Fly   395 -----------------------------------FRREAPFQSCMFRVRL-------PDNRAKY 417
                                               ||:....|.....::|       .:|..:.
 Frog   703 LVARLFDDIITDCSHALPDVKSMQGTTHLDQYLYRFRKTNLAQIVQAALKLKHDDCVEQENVMEQ 767

  Fly   418 ESDFFML-------------DIVNYM---RSELDTFK------LFQR------------------ 442
            ..|:.|.             |||.:|   ...:..::      ||.|
 Frog   768 AEDWLMRLKAMAEEPQNSLPDIVIWMLQGEKRVAYYRMPARDVLFSRNGSKCCGKNCGKLQTIFL 832

  Fly   443 KYPLQDDEQAKCLKVIVNNILTRIKEGL--DAHRFDHDVQPQRT----------------TWDIN 489
            |:|.:..:.||    :...:..::..||  |...|:|..|.:.:                .|...
 Frog   833 KFPQEGTQGAK----MPAQVRVQLWFGLAVDQKEFNHYAQGKLSVFAEAYENQTKLALVGNWGTT 893

  Fly   490 RQLY--LLDYFAKLPLELQNLKQKL-----------------------RSCFLE----------- 518
            ...|  ..|...|:.|..::.|...                       ...|:|
 Frog   894 GLTYPKYSDVTGKIKLPKESFKASTGWSWAGDWFISPEKTLLYDTDAGHMSFVEEVFENQARLPG 958

  Fly   519 ----HLDTSIGDVVNELQRLVAEIGSLSSMARTQDEW-PELVLSLSASGKDVGVC---------- 568
                |:..:..||..|......||..........||| .:...::...|.:.|:.
 Frog   959 GQWIHMTEAYSDVNGEKVLPKDEIECPPGWKWEDDEWSTDTNRAVDEQGWEYGITIPPDRKPKSW 1023

  Fly   569 --------RLNAKLFLNLRNQDADQ----------DQETLCWRL-------------KSFSFKSA 602
                    ....:.::.||.:|..|          :.|:..|..             |:.||:..
 Frog  1024 VPAEKMYHTNRRRRWVRLRRRDPKQIEILKKHKPDESESEGWEYASLFGWKFHLKYRKTDSFRRR 1088

  Fly   603 GCSHTCPNCGCTTA----IVSGCLSIVVERERKRFLAVVNKEWANIEPMLWQLN----------P 653
            ...........|.|    .:.|.|..:.:.:        :.:..|...|.:.:|          .
 Frog  1089 RWRRRMEPLERTGAAAVFALEGSLGGITDDK--------SDDGKNTSTMSFGVNRPTISCIFDYG 1145

  Fly   654 EQTHFLCHVYIHQAKVRPGGEKKNICDSHLRVLFADQACETYTSPGTLSPIWNAVITFNWVSLPG 718
            .:.|..|  ||:||:.....::.:..|.:..|.|..|:.:|.....||:|.|:..:.|:.:.:.|
 Frog  1146 NRYHLRC--YIYQARNLVPMDQDSFSDPYAIVSFLHQSQKTLVMKSTLNPTWDQTLIFHEIEVFG 1208

  Fly   719 GIGLYLKNPPLLSLEFYNSERSLPEDLVGMGSVAMSVISEDRASDSNWEDAGVFGCSKNPLRKLQ 783
            ......::||.:.:|.|:.:....::.:|.   .:...|.:|:...:|... :.| :|| :.:|.
 Frog  1209 DPETIKESPPNIVVEIYDHDTYGADEYMGR---CICKPSFERSPRLSWHPV-IMG-TKN-VGELL 1267

  Fly   784 RLKYLTP---PPLKWVPIARKGTLQAE---VLMSAEIIQISMESLTTGQNDK----KEPQLATG- 837
            ....|.|   |.:..:|     .|:.|   ||....|.:...|.|....:|.    ..||....
 Frog  1268 AAFELIPREKPAVHLIP-----GLEGEISGVLSELLIPRFFTEKLLDWSSDADLPYPPPQREANV 1327

  Fly   838 --IPMAIRPTMQNFVLEVFFVGLRNYSKSSMSSAGKRKINLMMGDLVLSSGPSTARIRNSINFLV 900
              :|..|:|.:|...:|:...||||.....::|.....:.:..||.::.|| ....::.:.||.|
 Frog  1328 YMVPQGIKPVLQRTAIEILAWGLRNLKSYQLASVTSPSLIVECGDELIQSG-VIKNVKKNPNFDV 1391

  Fly   901 AYASGVVSLPDQQDYWPAIIATDVLLSGFSSESILGAALIPNSSNFLQRDRTLKCVFKKEQEAAE 965
            ......|.||.:..|.|.||...:....|..:.::|...|.:...|       .|....|....|
 Frog  1392 CLLLMEVRLPREDLYCPPIIVKVIDNRQFGRKPVVGQCTIKSLEEF-------HCDPNSEDLEVE 1449

  Fly   966 --ASTTVSVDEDDE-----DEEEELEWEEEETKPSRISSWWMRLLFAFGLRPAPYANRHALRFHD 1023
              .|..|||...||     |::|.|       .|:::         |.|:..:...|..:.|
 Frog  1450 DGLSDNVSVTPRDEVLIDIDDKEPL-------IPTQL---------ADGMTSSAIINLSSSR--- 1495

  Fly  1024 DLDDHELVEEREFTWWTKFYNSMYWSAAEMCHEHKHR----LVIYYEELEKQAQFGYLQDWAVPV 1084
                ..|.||....||:|||.|:  ...|.|..:..:    |.:...|||....:..|.|:....
 Frog  1496 ----PSLHEEEFIDWWSKFYASI--GEKEKCGTYLEKGFDTLQVLDTELENIEDYEELSDFCRTF 1554

  Fly  1085 QLVHGVKFKKHGPPKED--IYATLKLQLKLTPCQCPVLEDPGGGGDMVRNMSNPIHPRHQSTLQS 1147
            :|..|    |.....||  :....|...|:    .|:.:||        ::..|.....|...:.
 Frog  1555 KLYRG----KTQDETEDPSVVGEFKGSFKI----YPLPDDP--------SVPRPAPQFRQLPAKG 1603

  Fly  1148 LGETVKLLVRVYVVQGVQMRPRDVKGDSDCYVKLFLGGKTFSDRAHFSPNHSNPVFGRLFEMEAT 1212
            |.|   .|||||:|:...::|:|..|..|.|||:.:|.|:.:|:.|:.|....||||::||:..|
 Frog  1604 LQE---CLVRVYIVRAFGLQPKDPNGKCDPYVKISIGKKSLNDQEHYIPCTLEPVFGKMFELTCT 1665

  Fly  1213 LPGDHMLQVMVYDHDKI-KDEVIGQTNIDLEDRWRTRHRATVGLANEYTKSGYNHWHDVKLPSEI 1276
            ||.:..|:|.:||:|.| |||.||:|.||||:|:.:::.|..||...|..||.|.|.|.:.|||:
 Frog  1666 LPLEKDLKVTLYDYDMISKDEKIGETVIDLENRFLSKYGARCGLPQSYCISGPNQWRDQRKPSEL 1730

  Fly  1277 LIDLCQKRGIQAPYYYGNVIEVDGMLFGDETLISKDEEL----------QERLSLAVLKNMDKLP 1331
            |....|:|..:.|.:..|.|    |....|..:|:.|:.          :|||:|.||:...
 Frog  1731 LRIFAQQRNFKPPNFKNNSI----MFRNHEYHVSELEDSKFPNPHQGPPEERLALHVLRRQG--- 1788

  Fly  1332 SFGYKLVPEHVETRSLCRDDFPNVEQGKLQLWIELFEANIYVPS-PIDITPVPPADFEVRVVVKN 1395
                 ||.||||||:|.....|::||||||:|::||..::..|. |.:|||.....:.:|.::.|
 Frog  1789 -----LVCEHVETRALYSPLQPDIEQGKLQMWVDLFPKSLGSPGPPFNITPRKAKRYYLRCIIWN 1848

  Fly  1396 LVGIQAGDKNIFGKLMSDVYVIGW-CEDEDKRQSTDIHYRSFAGDAAFNWRMVFGLKYSPNEDLM 1459
            ...:...|.:|.|:.|||:||..| ...|:.:|.||:||||..|:..||||:||...|.|.|.:.
 Frog  1849 TKDVILDDVSITGEKMSDIYVKSWLIGHEENKQKTDVHYRSMGGEGNFNWRLVFPFDYLPAEQVC 1913

  Fly  1460 VIRRKAGL--LEEIEFKKPPIIYLQVWDKDVLTKDEYLAALELNLSNMYAPYPAAQLCK----PY 1518
            .:.||...  |::.|.|.||.:.:|:||.|..:.|:||.:::|:|:.|..|...|:.|:    ..
 Frog  1914 SVSRKEHFWSLDKTENKIPPNLIIQIWDNDKFSFDDYLGSVQLDLNRMPRPAKTAEKCRLDLLDE 1978

  Fly  1519 PKKRKRINLFKRKVINGWFPLQSNAHPSQRSQAAVQNGKMQLSIEVCTDVEAVNRPAGRGQDPP- 1582
            .:.....:||::|.:.||:|.     ..|.....:..||:::::|:..:.|...||||.|:|.|
 Frog  1979 VESANHCSLFEQKTVKGWWPC-----VGQEGDEKILAGKVEITLEIVNEQEHDERPAGIGRDEPN 2038

  Fly  1583 --MALEPPYRPDSSFNPLTHPCKSFQHILWPVIRKY-----VLWTLLILIVILGLVLF-FSNLPA 1639
              ..||.|.||::||...|.|.|:.::|||   |:|     |.:.|.||::.||:.|: |.|..|
 Frog  2039 MNPRLEDPKRPETSFLWFTSPYKTLKYILW---RRYKWLILVFFLLFILLLFLGIFLYSFPNYAA 2100

  Fly  1640 KLMTIP 1645
            ..:..|
 Frog  2101 MKLVKP 2106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mfr	NP_001137919.1	C2	12..122	CDD:472691	27/109 (25%)
		C2	<213..293	CDD:472691	21/108 (19%)
		C2D_Ferlin	658..818	CDD:175984	37/165 (22%)
		C2E_Ferlin	1155..1277	CDD:176002	56/122 (46%)
		C2F_Ferlin	1388..1517	CDD:176020	49/135 (36%)
		Ferlin_C	1524..1619	CDD:435183	34/102 (33%)
dysf	XP_031751122.1	C2	5..125	CDD:472691
		C2B_Ferlin	214..323	CDD:175978	27/109 (25%)
		FerI	321..371	CDD:462377	18/67 (27%)
		C2C_Ferlin	377..549	CDD:175985	30/176 (17%)
		FerA	690..754	CDD:462389	5/63 (8%)
		FerB	782..855	CDD:462376	11/76 (14%)
		DysFN	871..929	CDD:214777	6/57 (11%)
		DysFN	942..998	CDD:214777	11/55 (20%)
		C2D_Ferlin	1148..1276	CDD:175984	31/135 (23%)
		C2E_Ferlin	1608..1731	CDD:176002	56/122 (46%)
		C2F_Ferlin	1842..1973	CDD:176020	49/130 (38%)
		Ferlin_C	1985..>2073	CDD:435183	33/95 (35%)