Protein Alignment TrpA1 and TRPA1

DIOPT Version :10

• Sequence 1: NP_001261600.1
• Gene: TrpA1 / 39015
• FlyBaseID: FBgn0035934
• Length: 1232
• Species: Drosophila melanogaster
• Sequence 2: XP_011515926.1
• Gene: TRPA1 / 8989
• HGNCID: 497
• Length: 1144
• Species: Homo sapiens
• Alignment Length: 1105
• Identity: 397/1105 - (35%)
• Similarity: 632/1105 - (57%)
• Gaps: 86/1105 - (7%)

  Fly   130 HQAAARNRVNILRYI-RDQNGD-FNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQ 192
            |.|||..::.::..| ||.:.: .:..|:.||||||.|||.:..:::.:|||...:..:.|....
Human    93 HYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM 157

  Fly   193 APVHLATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPC 257
            ||:|:|.:....:.::|:.::| .||:...||:|.||:.:|...::.|..:||:.:    ..|||
Human   158 APLHIAVQGMNNEVMKVLLEHR-TIDVNLEGENGNTAVIIACTTNNSEALQILLKK----GAKPC 217

  Fly   258 NN---GYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVEL 319
            .:   |.:|||:||.:.|.:.||:..::||:.|.:|:..|:|.::....|||.||..||::.:::
Human   218 KSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKM 282

  Fly   320 CLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDH 384
            ||.:||:|...:....|.:|.|..|||.:|||||.........: ::.||....|.||.||:|||
Human   283 CLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDI-VNTTDGCHETMLHRASLFDH 346

  Fly   385 PDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNG 449
            .::..||::.|||||.:|.|.||||:||.:.:.|..|:||:..||.:.:||...||.||..:...
Human   347 HELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQP 411

  Fly   450 GRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNES 514
            ..|.:...:....|   |:|.|:.::|:.||:|||||.|.|...|:.||:.....|:.|:.:.:|
Human   412 YGLKNLRPEFMQMQ---QIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKS 473

  Fly   515 PLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHT 579
            ||||||.|||.||.::||.....:.::||.|..||||||::::.||.:||||||.:|||...||.
Human   474 PLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHN 538

  Fly   580 GRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNV 644
            |...|..|:|.|||:|::::...:....|::|:|||||||.|..|....|:::|:|....:|.|.
Human   539 GWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNK 603

  Fly   645 LDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKHP---CVTLALIASMPKVFEAVQDKCI 706
            ...|.:..|::.|..|..|.:: ..:|.:|.:.:.|...|   |....:|..:|:..:.:.|.|:
Human   604 QQASFLHLALHNKRKEVVLTII-RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCM 667

  Fly   707 TKANCKKDSKSFYIKYSFAFLQCPFMFAKIDEKTGESITTASPI--PLPALNTMVTHGRVELLAH 769
            ..:...|..:.:||:|:|.:||||..|.|   ||    .|...|  ||.|||.||.:.|:|||.|
Human   668 LHSTEDKSCRDYYIEYNFKYLQCPLEFTK---KT----PTQDVIYEPLTALNAMVQNNRIELLNH 725

  Fly   770 PLSQKYLQMKWNSYGKYFHLANLLIYSIFLVFVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQL 834
            |:.::||.|||.:||...|:.||..|.:.|:.:||    ::.||:.....|.|
Human   726 PVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTI----LVVNIKPGMAFNST------------ 774

  Fly   835 TMNLSQNPSVASQIRLDSCEERINRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNL 899
              .:....|..|:| ||:....:.:|     |.:::.:..:....:|..||:|||.:|.::..|:
Human   775 --GIINETSDHSEI-LDTTNSYLIKT-----CMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNV 831

  Fly   900 ISWVLYISALVMVTPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQT 964
            :.|::|.:.::.|.|.|.....  .:.:...:|||:..|...||:||||:..||::||...||:|
Human   832 LEWIIYTTGIIFVLPLFVEIPA--HLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKT 894

  Fly   965 LIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYY 1029
            |::..:||..|::||||:|||||: :.||      ||:..:|:::|||||||::::..:::..|.
Human   895 LLRSTVVFIFLLLAFGLSFYILLN-LQDP------FSSPLLSIIQTFSMMLGDINYRESFLEPYL 952

  Fly  1030 RDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPH 1094
            |::|..|:.||..|..|.|.:||:|||||||||||||..|:::|.|||:||||.|||.||:|||.
Human   953 RNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPL 1017

  Fly  1095 VWLQRVDKMELIEYPNETK---------CKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYIN 1150
            .:|::||:...|.|||:.:         |.| ||...:|:               ...|.|..:.
Human  1018 WFLRKVDQKSTIVYPNKPRSGGMLFHIFCFL-FCTGEIRQ---------------EIPNADKSLE 1066

  Fly  1151 AELERQRRKLRDISRMLEQQHHLVRLIVQKMEIKTEADDVDEGISPNELRSVVGLRSAGGNRWNS 1215
            .|:.:|:.:|:|::.:||:||.|::||:|||||.:|.:|.|...|..: |..........:|||:
Human  1067 MEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQD-RFKKEQMEQRNSRWNT 1130

  Fly  1216  1215
            Human  1131  1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..183	CDD:463710	20/54 (37%)
		ANK repeat	125..155	CDD:293786	7/26 (27%)
		ANKYR	140..461	CDD:440430	113/325 (35%)
		ANK repeat	157..199	CDD:293786	16/41 (39%)
		ANK repeat	259..298	CDD:293786	15/41 (37%)
		ANK repeat	300..330	CDD:293786	12/29 (41%)
		ANK repeat	336..369	CDD:293786	11/32 (34%)
		ANKYR	368..634	CDD:440430	113/265 (43%)
		ANK repeat	374..402	CDD:293786	15/27 (56%)
		ANK repeat	404..476	CDD:293786	24/71 (34%)
		ANK repeat	478..509	CDD:293786	13/30 (43%)
		TRPV	481..1093	CDD:454755	233/616 (38%)
		ANK repeat	511..545	CDD:293786	16/33 (48%)
		ANK repeat	547..576	CDD:293786	17/28 (61%)
		ANK repeat	579..611	CDD:293786	9/31 (29%)
		ANK repeat	613..638	CDD:293786	12/24 (50%)
TRPA1	XP_011515926.1	ANKYR	72..371	CDD:440430	100/283 (35%)
		ANK repeat	92..120	CDD:293786	7/26 (27%)
		ANK repeat	122..153	CDD:293786	12/30 (40%)
		ANK repeat	155..187	CDD:293786	8/32 (25%)
		ANK repeat	189..214	CDD:293786	7/28 (25%)
		ANK repeat	222..261	CDD:293786	15/38 (39%)
		ANKYR	254..544	CDD:440430	119/293 (41%)
		ANK repeat	266..294	CDD:293786	12/27 (44%)
		ANK repeat	296..364	CDD:293786	28/68 (41%)
		ANK repeat	366..397	CDD:293786	13/30 (43%)
		ANK repeat	437..468	CDD:293786	13/30 (43%)
		ANK repeat	470..504	CDD:293786	16/33 (48%)
		ANK repeat	506..536	CDD:293786	17/29 (59%)
		Ank_2	511..602	CDD:463710	38/90 (42%)
		ANK repeat	538..570	CDD:293786	9/31 (29%)
		ANK repeat	572..597	CDD:293786	12/24 (50%)
		Ion_trans	<821..997	CDD:459842	75/184 (41%)