DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and Otof

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_114081.2	Gene:	Otof / 83762	MGIID:	1891247	Length:	1997	Species:	Mus musculus

Alignment Length:	784	Identity:	134/784 - (17%)
Similarity:	256/784 - (32%)	Gaps:	231/784 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 ISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTP---VHLACAQGAIDIVKLMFE 355
            :..|.:||...:::::.....||          ...:..||..|   |..|..:|...:.|..:|
Mouse   420 VKIYRAEGLPRMNTSLMANVKKA----------FIGENKDLVDPYVQVFFAGQKGKTSVQKSSYE 474

  Fly   356 ------------MQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSP 408
                        ..|:.||:.:...|..|:..:...:.|             .|:..:..:....
Mouse   475 PLWNEQVVFTDLFPPLCKRMKVQIRDSDKVNDVAIGTHF-------------IDLRKISNDGDKG 526

  Fly   409 LLLAASRSGWKTVHLLIR--------------LGACISVKDAAARNVLHFVIMNGGRLTDFAEQV 459
            .|.... ..|..::...|              ||..:|.:   ||.:|...:    .:.|.:...
Mouse   527 FLPTLG-PAWVNMYGSTRNYTLLDEHQDLNEGLGEGVSFR---ARLMLGLAV----EILDTSNPE 583

  Fly   460 ANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACIN---LKNNNNESPLHFAAR 521
            ....|:.|::......:|  |:           ..:|.....||.:.   :...|.:.|:.|...
Mouse   584 LTSSTEVQVEQATPVSES--CT-----------GRMEEFFLFGAFLEASMIDRKNGDKPITFEVT 635

  Fly   522 YGRY-NTV------------RQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGAL 573
            .|.| |.|            ::..|.|:...|.|.||..|.....::|......:...:.:|. .
Mouse   636 IGNYGNEVDGMSRPLRPRPRKEPGDEEEVDLIQNSSDDEGDEAGDLASVSSTPPMRPQITDRN-Y 699

  Fly   574 LHRDHTGRNPLQLAAMSGYTETIELLH--SVHSHLLDQVDKDGNTALHL-----ATMENKPHAIS 631
            .|..:..|.|. :...|.:.:....|:  ::..|:.|::::..|....:     :..|.:...:.
Mouse   700 FHLPYLERKPC-IYIKSWWPDQRRRLYNANIMDHIADKLEEGLNDVQEMIKTEKSYPERRLRGVL 763

  Fly   632 VLMSMGCKLVYNVLDMSAIDY--AIYYKYPEAALAMVTHE-----ERANEVMA----------LR 679
            ..:|.||   :..|.:|..|.  :...:.....|.....|     ::|..:.|          ||
Mouse   764 EELSCGC---HRFLSLSDKDQGRSSRTRLDRERLKSCMRELESMGQQAKSLRAQVKRHTVRDKLR 825

  Fly   680 SDKHPCVTLALIASMPKVFEAVQDKCI-TKANCKKDSKSFYIKYSFAFLQCP---FMFAKIDEKT 740
            |.::....|..:|..|:  .::.|..| ..:|.|:          .|:.:.|   .:|:.::|:.
Mouse   826 SCQNFLQKLRFLADEPQ--HSIPDVFIWMMSNNKR----------IAYARVPSKDLLFSIVEEEL 878

  Fly   741 GESITTASP--IPLPALNTMVTHG-----RVELLAHPLSQKYLQMKWNSYGKYFHLANL------ 792
            |:.......  :.||......:.|     ::||        ||.:..:...|.| |..|
Mouse   879 GKDCAKVKTLFLKLPGKRGFGSAGWTVQAKLEL--------YLWLGLSKQRKDF-LCGLPCGFEE 934

  Fly   793 ----------------LIYS---IFLVFVTIYSSLMMNNIELKAGDNKTMSQ-YCNMGWEQLTMN 837
                            |:|:   .|.:...:|.:.     .|.|.|:..:|. :..:    ..:|
Mouse   935 VKAAQGLGLHSFPPISLVYTKKQAFQLRAHMYQAR-----SLFAADSSGLSDPFARV----FFIN 990

  Fly   838 LSQNPSVASQIRLDSCEERINRTTAILFCAVVIV----VYILLNSMRE-----LIQIYQQ----K 889
            .||            |.|.:|.|....:..:::.    :|...:.:|:     :|:||.|    |
Mouse   991 QSQ------------CTEVLNETLCPTWDQMLVFDNLELYGEAHELRDDPPIIVIEIYDQDSMGK 1043

  Fly   890 LHYILETVNLISWVLYISALVMVT------PAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRF 948
            ..::..|        :...||.:.      |.|.|......|:..:|:....|:.|.||
Mouse  1044 ADFMGRT--------FAKPLVKMADEAYCPPRFPPQLEYYQIYRGSATAGDLLAAFELL------ 1094

  Fly   949 DQVG 952
             |:|
Mouse  1095 -QIG 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560
		ANK	121..246	CDD:238125
		ANK repeat	125..155	CDD:293786
		ANK repeat	157..199	CDD:293786
		Ank_2	230..330	CDD:289560	5/35 (14%)
		ANK repeat	259..298	CDD:293786	0/3 (0%)
		ANK	298..425	CDD:238125	21/141 (15%)
		ANK repeat	300..330	CDD:293786	4/29 (14%)
		Ank_2	305..402	CDD:289560	17/111 (15%)
		ANK repeat	336..369	CDD:293786	9/47 (19%)
		ANK repeat	374..402	CDD:293786	2/27 (7%)
		ANK repeat	404..476	CDD:293786	12/85 (14%)
		ANK	473..599	CDD:238125	25/141 (18%)
		ANK repeat	478..509	CDD:293786	4/33 (12%)
		Ank_2	483..572	CDD:289560	19/104 (18%)
		ANK repeat	511..545	CDD:293786	11/46 (24%)
		ANK	542..662	CDD:238125	21/128 (16%)
		ANK repeat	547..576	CDD:293786	3/28 (11%)
		Ank_2	552..643	CDD:289560	14/97 (14%)
		ANK repeat	579..611	CDD:293786	6/33 (18%)
		ANK repeat	613..638	CDD:293786	3/29 (10%)
		Ion_trans	858..1074	CDD:278921	23/114 (20%)
Otof	NP_114081.2	C2A_Ferlin	3..130	CDD:176019
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..167
		C2B_Ferlin	250..361	CDD:175978
		FerI	359..409	CDD:369715
		C2C_Ferlin	417..566	CDD:175985	26/172 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..692		9/48 (19%)
		FerB	842..916	CDD:369714	16/93 (17%)
		C2D_Ferlin	959..1096	CDD:175984	32/172 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1253..1272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1326
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1343..1402
		C2E_Ferlin	1493..1616	CDD:176002
		C2F_Ferlin	1733..1866	CDD:176020
		Ferlin_C	1876..1994	CDD:374404
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900