DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and KEG

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_196857.2	Gene:	KEG / 831197	AraportID:	AT5G13530	Length:	1625	Species:	Arabidopsis thaliana

Alignment Length:	730	Identity:	144/730 - (19%)
Similarity:	236/730 - (32%)	Gaps:	261/730 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 MIIERSAGPKRIEIDGDDADTPLEAIL-----PAEPPAE-----VCLLRDSPFRILRAAESGN-- 103
            ::::|..|..:.|:..::....||.||     .|...||     |..:...|..:|..| |||
plant   221 LLMDRCFGSVQSEMQRNEGRLTLEQILRYGADVARGVAELHAAGVICMNIKPSNLLLDA-SGNAV 284

  Fly   104 LDDF------------KRLFMADNSRIALKDAKGRTAAHQAA--ARNRVNILRYIRDQNGDFNAK 154
            :.|:            |.....|:|::.|.......:.|..|  |...|..|.:          :
plant   285 VSDYGLAPILKKPTCQKTRPEFDSSKVTLYTDCVTLSPHYTAPEAWGPVKKLFW----------E 339

  Fly   155 DNAGNTPLHIAVESDAYDALDYLL-----SIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYR 214
            |.:|.:|     ||||:.....|:     |.|.| |:..|:....|        ||:.:|..||.
plant   340 DASGVSP-----ESDAWSFGCTLVEMCTGSTPWD-GLSREEIFQAV--------VKARKVPPQYE 390

  Fly   215 NVIDIQQGGEHGRTALHLAAIYDHEECARI--------------LITEFDACPRKPC---NNGYY 262
            .::.:....|..:..         .||.:.              .:......||.|.   :||..
plant   391 RIVGVGIPRELWKMI---------GECLQFKPSKRPTFNAMLATFLRHLQEIPRSPSASPDNGIA 446

  Fly   263 PIHEA----AKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKS 323
            .|.|.    |..|::..:                   |.|:..|  ||..|..||.:.|...|..
plant   447 KICEVNIVQAPRATNIGV-------------------FQDNPNN--LHRVVLEGDFEGVRNILAK 490

  Fly   324 GAK----------ISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHC 378
            .|.          :..|..|..:.:||||.:|:.::|:.:.|...
plant   491 AAAGGGGSSVRSLLEAQNADGQSALHLACRRGSAELVEAILEYGE-------------------- 535

  Fly   379 ASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLH 443
                             |:::.:||:...||:.|.:....:.||:||:.||.:.
plant   536 -----------------ANVDIVDKDGDPPLVFALAAGSPQCVHVLIKKGANVR----------- 572

  Fly   444 FVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLK 508
                  .||                      ::..|.|..|..|..|....:..|:..||..|..
plant   573 ------SRL----------------------REGSGPSVAHVCSYHGQPDCMRELLVAGADPNAV 609

  Fly   509 NNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLH----------------ISSQ 557
            ::..|:.||.|.. .:|.....::....||..:..|:...:||||                :||.
plant   610 DDEGETVLHRAVA-KKYTDCAIVILENGGSRSMTVSNAKCLTPLHMCVATWNVAVIKRWVEVSSP 673

  Fly   558 QGHTRVVQL------LLNRGALLHRDH--TGRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDG 614
            :..::.:.:      .|...|.:.:||  .||..:|:...:|...|.            |..:.|
plant   674 EEISQAINIPSPVGTALCMAASIRKDHEKEGRELVQILLAAGADPTA------------QDAQHG 726

  Fly   615 NTALHLATMENKPHAISVLMSMG----CKLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEV 675
            .||||.|.|.|....:.|::..|    .:.|:|.:.:.
plant   727 RTALHTAAMANNVELVRVILDAGVNANIRNVHNTIPLH--------------------------- 764

  Fly   676 MALRSDKHPCVTLAL 690
            |||....:.||:|.|
plant   765 MALARGANSCVSLLL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560	27/113 (24%)
		ANK	121..246	CDD:238125	27/145 (19%)
		ANK repeat	125..155	CDD:293786	5/31 (16%)
		ANK repeat	157..199	CDD:293786	13/46 (28%)
		Ank_2	230..330	CDD:289560	22/130 (17%)
		ANK repeat	259..298	CDD:293786	7/42 (17%)
		ANK	298..425	CDD:238125	27/136 (20%)
		ANK repeat	300..330	CDD:293786	9/39 (23%)
		Ank_2	305..402	CDD:289560	18/106 (17%)
		ANK repeat	336..369	CDD:293786	7/32 (22%)
		ANK repeat	374..402	CDD:293786	1/27 (4%)
		ANK repeat	404..476	CDD:293786	11/71 (15%)
		ANK	473..599	CDD:238125	32/149 (21%)
		ANK repeat	478..509	CDD:293786	9/30 (30%)
		Ank_2	483..572	CDD:289560	22/110 (20%)
		ANK repeat	511..545	CDD:293786	7/33 (21%)
		ANK	542..662	CDD:238125	29/147 (20%)
		ANK repeat	547..576	CDD:293786	8/50 (16%)
		Ank_2	552..643	CDD:289560	25/118 (21%)
		ANK repeat	579..611	CDD:293786	6/31 (19%)
		ANK repeat	613..638	CDD:293786	10/28 (36%)
		Ion_trans	858..1074	CDD:278921
KEG	NP_196857.2	RING-HC_ScPSH1_like	9..56	CDD:319482
		RING-HC finger (C3HC4-type)	10..55	CDD:319482
		S_TKc	138..424	CDD:214567	49/236 (21%)
		ANKYR	<427..571	CDD:223738	41/201 (20%)
		ANK repeat	472..508	CDD:293786	8/35 (23%)
		ANK repeat	510..542	CDD:293786	9/68 (13%)
		PHA03095	517..>857	CDD:222980	72/379 (19%)
		ANK repeat	544..575	CDD:293786	9/47 (19%)
		ANK repeat	577..610	CDD:293786	9/32 (28%)
		ANK repeat	688..722	CDD:293786	9/45 (20%)
		ANK repeat	725..756	CDD:293786	10/30 (33%)
		ANK repeat	758..789	CDD:293786	8/49 (16%)
		ANK repeat	791..828	CDD:293786
		SH3_15	909..984	CDD:375773
		SH3_15	1053..1110	CDD:375773
		SH3_15	1116..1166	CDD:375773
		SH3_15	1242..1363	CDD:375773
		SH3_15	1426..1488	CDD:375773
		SH3_15	1560..1617	CDD:375773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000