DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and Fer1l4

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_001130028.1 Gene:Fer1l4 / 74562 MGIID:1921812 Length:1994 Species:Mus musculus


Alignment Length:321 Identity:61/321 - (19%)
Similarity:102/321 - (31%) Gaps:106/321 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 PDLMEAQPKLLPKPRSNSSGSTGRNSKYWIFSMIIERSAGPKRIEIDGDDADTPLEAILPAEPPA 83
            |:.:|.:|...|:    |.|....:...|              |:|...|        :||.||.
Mouse  1643 PEHVETRPLYHPR----SPGLLQGSLHMW--------------IDIFPSD--------VPAPPPV 1681

  Fly    84 EVCLLRDSPFR---ILRAAESGNLDDFKRLFMADNSRIALKD-AKGRTAAHQAAARNRVNILRYI 144
            ::...:...:.   ::...:...|||...|....:|.|.:|. .||.....|             
Mouse  1682 DIKPRQPISYELRVVIWNTDDVALDDVNPLTGERSSDIYVKSWVKGLEQDRQ------------- 1733

  Fly   145 RDQNGDFNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHL------------ 197
             :.:..||:....||........      .|||   |.:..|...:|..|..|            
Mouse  1734 -ETDVHFNSLTGEGNFNWRFVFR------FDYL---PTEREVSVRRKPGPFALEEAEFRQPAVLV 1788

  Fly   198 --ATELNKVKSLRVMGQYR-NVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCN- 258
              ..:.:::.:...:|... .:.|:.:|..            |.|.|:..|..: .|.||  || 
Mouse  1789 LQVWDYDRISANDFLGSLELQLPDMVRGAR------------DPEHCSVRLALD-GAGPR--CNL 1838

  Fly   259 ------NGYYPI----------HEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNV 303
                  .|::|:          .||.:..:.|..:      .:|...|.|.:.|.|:.|||
Mouse  1839 FRCHRLRGWWPVVKMKDMEDVEREAREAQAGKKRK------RKRRAGRPEDLEFTDTGGNV 1893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 19/93 (20%)
ANK 121..246 CDD:238125 22/140 (16%)
ANK repeat 125..155 CDD:293786 4/29 (14%)
ANK repeat 157..199 CDD:293786 10/55 (18%)
Ank_2 230..330 CDD:289560 22/91 (24%)
ANK repeat 259..298 CDD:293786 9/48 (19%)
ANK 298..425 CDD:238125 4/6 (67%)
ANK repeat 300..330 CDD:293786 3/4 (75%)
Ank_2 305..402 CDD:289560
ANK repeat 336..369 CDD:293786
ANK repeat 374..402 CDD:293786
ANK repeat 404..476 CDD:293786
ANK 473..599 CDD:238125
ANK repeat 478..509 CDD:293786
Ank_2 483..572 CDD:289560
ANK repeat 511..545 CDD:293786
ANK 542..662 CDD:238125
ANK repeat 547..576 CDD:293786
Ank_2 552..643 CDD:289560
ANK repeat 579..611 CDD:293786
ANK repeat 613..638 CDD:293786
Ion_trans 858..1074 CDD:278921
Fer1l4NP_001130028.1 C2A_Ferlin 3..129 CDD:176019
C2B_Ferlin 225..335 CDD:175978
FerI 333..383 CDD:285377
C2C_Ferlin 391..540 CDD:175985
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 554..606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..686
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..710
FerB 862..931 CDD:285376
C2D_Ferlin 967..1101 CDD:175984
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1276
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1322..1361
C2E_Ferlin 1449..1572 CDD:176002
C2F_Ferlin 1692..1825 CDD:176020 28/167 (17%)
Ferlin_C 1834..1985 CDD:292783 17/68 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1862..1885 6/28 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1326
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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