DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TrpA1 and FER1L6

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:XP_011515533.1 Gene:FER1L6 / 654463 HGNCID:28065 Length:1880 Species:Homo sapiens


Alignment Length:656 Identity:120/656 - (18%)
Similarity:209/656 - (31%) Gaps:194/656 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 KRLFMADNSRIALKDAKGRTAA------HQ-------------------AAARNRVNILRYIRDQ 147
            |.|.:|:.   |.||::|.|.|      ||                   |:.:.|..:|..|.| 
Human    38 KGLILANK---AAKDSQGDTEALQEEPSHQEGPRGDLVHDDASIFPVPSASPKRRSKLLTKIHD- 98

  Fly   148 NGDFNAKDNAGNTPLHIAVESDAY---DALDYLLSIPVDTGVLNEKKQAPVHLATE---LNKVKS 206
             |:..::    |..:.|.:.....   :.:|.:::|.:.    :||||:.|...|.   .|:...
Human    99 -GEVRSQ----NYQIAITITEARQLVGENIDPVVTIEIG----DEKKQSTVKEGTNSPFYNEYFV 154

  Fly   207 LRVMGQYRNVID--IQQGGEH---------GRTALHLAAIYD---HEECAR-ILITEFDACPRKP 256
            ...:|...::.|  |:....|         |...:.|..:|:   |:.|.: .|:|  |....:.
Human   155 FDFIGPQVHLFDKIIKISVFHHKLIGSVLIGSFKVDLGTVYNQPGHQFCNKWALLT--DPGDIRT 217

  Fly   257 CNNGYY--PIHEAAK----NASSKTMEVFFQWGEQRGCTREEM--------------------IS 295
            ...||.  .|....|    ..|.||.:           |.|.:                    :.
Human   218 GTKGYLKCDISVMGKGDVLKTSPKTSD-----------TEEPIEKNLLIPNGFPLERPWARFYVR 271

  Fly   296 FYDSEGNVPLHSAVHGGDIKA------------VELCLKSGAKISTQQHDLSTPV-HLACAQGAI 347
            .|.:||...::|::.....||            ||:........:|.|.:.:.|| |...     
Human   272 LYKAEGLPKMNSSIMANVTKAFVGDSKDLVDPFVEVSFAGQMGRTTVQKNCADPVWHEQV----- 331

  Fly   348 DIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPL-LL 411
             |.|.||  .|:.:|:.:...|...|..:..|:.|             .|:..:..|..... .|
Human   332 -IFKEMF--PPLCRRVKIQVWDEGSMNDVALATHF-------------IDLKKISNEQDGDKGFL 380

  Fly   412 AASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQ--------AQL 468
            ......|..::...|..:.:.............|...|..|.:.|.::.:.:.|        .:|
Human   381 PTFGPAWINLYGSPRNHSLMDDYQEMNEGFGEGVSFRGRILVEIAVEILSGRAQESKFSKALKEL 445

  Fly   469 KLLLNEKDSMGCSPLHYASR--DGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQL 531
            ||...:|||........|.:  ||..:...|          |.|:.|..:.      .::...::
Human   446 KLPSKDKDSKSSKGKDKADKTEDGKSQQASN----------KTNSTEVEVE------SFDVPPEI 494

  Fly   532 LDSEKGSFIINESDGA-----------GMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQ 585
            :..:...|::   .||           |..|:......|         |.|.|:  |....:..:
Human   495 VPEKNEEFLL---FGAFFEATMIDRKIGDKPISFEVSIG---------NFGNLI--DGGSHHGSK 545

  Fly   586 LAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAI 650
            .:|.|...:.:.|||.....:...|.         ..|.:..|....|::.|.: .||.|...|.
Human   546 KSAESAEEDLLPLLHEGQGDVAHDVP---------IPMASTTHPEKPLVTEGNR-NYNYLPFEAK 600

  Fly   651 DYAIYY 656
            ...:|:
Human   601 KPCVYF 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 21/107 (20%)
ANK 121..246 CDD:238125 33/170 (19%)
ANK repeat 125..155 CDD:293786 11/54 (20%)
ANK repeat 157..199 CDD:293786 9/44 (20%)
Ank_2 230..330 CDD:289560 24/141 (17%)
ANK repeat 259..298 CDD:293786 9/64 (14%)
ANK 298..425 CDD:238125 26/140 (19%)
ANK repeat 300..330 CDD:293786 7/41 (17%)
Ank_2 305..402 CDD:289560 21/109 (19%)
ANK repeat 336..369 CDD:293786 9/33 (27%)
ANK repeat 374..402 CDD:293786 3/27 (11%)
ANK repeat 404..476 CDD:293786 12/80 (15%)
ANK 473..599 CDD:238125 22/138 (16%)
ANK repeat 478..509 CDD:293786 4/32 (13%)
Ank_2 483..572 CDD:289560 14/101 (14%)
ANK repeat 511..545 CDD:293786 2/33 (6%)
ANK 542..662 CDD:238125 24/126 (19%)
ANK repeat 547..576 CDD:293786 7/39 (18%)
Ank_2 552..643 CDD:289560 15/90 (17%)
ANK repeat 579..611 CDD:293786 5/31 (16%)
ANK repeat 613..638 CDD:293786 3/24 (13%)
Ion_trans 858..1074 CDD:278921
FER1L6XP_011515533.1 C2B_Ferlin 103..212 CDD:175978 22/118 (19%)
FerI 210..259 CDD:285377 11/61 (18%)
C2C_Ferlin 267..418 CDD:175985 29/171 (17%)
FerB 736..807 CDD:285376
C2D_Ferlin 849..982 CDD:175984
C2E_Ferlin 1380..1503 CDD:176002
C2F_Ferlin 1620..1753 CDD:176020
Ferlin_C 1764..1873 CDD:292783
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1326
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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