DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TrpA1 and SOWAHC

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_075392.2	Gene:	SOWAHC / 65124	HGNCID:	26149	Length:	525	Species:	Homo sapiens

Alignment Length:	163	Identity:	46/163 - (28%)
Similarity:	79/163 - (48%)	Gaps:	29/163 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 EKDSMG-----CSPLHYA----SRDGHIRSLENLIRLGACINLKNN--NNESPLHFAARYGRYNT 527
            |::|.|     ..||.:|    :.||...|||.|:.....:.:|.:  ...:.||:||::||...
Human   253 EEESSGGGSVTLDPLEHAWMLSASDGKWDSLEGLLTCEPGLLVKRDFITGFTCLHWAAKHGRQEL 317

  Fly   528 VRQLLD-SEKGSFIIN--ESDGAGMTPLHISSQQGHTRVVQLLLNRGA----LLHRDHTGRNPLQ 585
            :..|:: :.|....:|  .....|.|.||:::..||..||:||:  ||    :..||::|:...|
Human   318 LAMLVNFANKHQLPVNIDARTSGGYTALHLAAMHGHVEVVKLLV--GAYDADVDIRDYSGKKASQ 380

  Fly   586 LAAMSGYTETIELLHSVHSHLLDQVDK-DGNTA 617
            ..:.| ..|.|:       :|:..:|: ||.:|
Human   381 YLSRS-IAEEIK-------NLVGALDEGDGESA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560
		ANK	121..246	CDD:238125
		ANK repeat	125..155	CDD:293786
		ANK repeat	157..199	CDD:293786
		Ank_2	230..330	CDD:289560
		ANK repeat	259..298	CDD:293786
		ANK	298..425	CDD:238125
		ANK repeat	300..330	CDD:293786
		Ank_2	305..402	CDD:289560
		ANK repeat	336..369	CDD:293786
		ANK repeat	374..402	CDD:293786
		ANK repeat	404..476	CDD:293786	1/1 (100%)
		ANK	473..599	CDD:238125	41/142 (29%)
		ANK repeat	478..509	CDD:293786	10/39 (26%)
		Ank_2	483..572	CDD:289560	28/97 (29%)
		ANK repeat	511..545	CDD:293786	9/36 (25%)
		ANK	542..662	CDD:238125	25/83 (30%)
		ANK repeat	547..576	CDD:293786	12/32 (38%)
		Ank_2	552..643	CDD:289560	22/71 (31%)
		ANK repeat	579..611	CDD:293786	6/31 (19%)
		ANK repeat	613..638	CDD:293786	3/5 (60%)
		Ion_trans	858..1074	CDD:278921
SOWAHC	NP_075392.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..263		3/9 (33%)
		Ank_2	272..372	CDD:289560	28/101 (28%)
		ANK	301..>375	CDD:238125	23/75 (31%)
		ANK 1	301..330		8/28 (29%)
		ANK repeat	302..338	CDD:293786	9/35 (26%)
		ANK repeat	340..372	CDD:293786	12/33 (36%)
		ANK 2	340..370		12/31 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..525
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030