DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and Fer1l6

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_001357841.1	Gene:	Fer1l6 / 631797	MGIID:	3645398	Length:	1873	Species:	Mus musculus

Alignment Length:	1039	Identity:	192/1039 - (18%)
Similarity:	319/1039 - (30%)	Gaps:	362/1039 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PKL-YNGVYSGQCGALSPPDLMEAQPKLLPKPRSNSSG--STGRN----------------SKY- 46
            ||| |:.::   ||.||..||: |..:||..|.|...|  .||..                |||
Mouse   945 PKLSYHPIF---CGNLSGGDLL-AVFELLQVPPSGLQGLPPTGPPDITQIYPVPSNIRPVLSKYR 1005

  Fly    47 -----W---------IFS-----MIIERSAGPKR--------------IEIDGDDADTPLEAILP 78
                 |         :.|     ::||...|..:              ::.:..:.:.|...:|
Mouse  1006 VEVLFWGVREMKKVQLLSVDRPQVLIECGGGGVKSCVIQSYKNNPNFSVQAEAFEVELPENELL- 1069

  Fly    79 AEPPAEVCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQA-----AARNRV 138
             .||..:|::....|.......:..::..|:.........||........|..|     ||....
Mouse  1070 -HPPLSICVVDWRAFGRSTLVGTYTINCLKQFLCKPRETFALTSQTDGDGARPAISDSLAATESS 1133

  Fly   139 NILRYIRDQNGDFNAKDNAGNTPLHIAVE---------SDAYDALDYLLSIPVDTGVLNEKKQAP 194
            |:|...:|...|            |:.|:         ..|......|:.|| |:..:.|.:..|
Mouse  1134 NLLSSSQDLPAD------------HVYVDVEPPPTMLPDSAQAQTATLVDIP-DSSPMLETEHKP 1185

  Fly   195 V--------HLATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDA 251
            |        |...:..|........:.|.:.|     |.....:...:.|         ......
Mouse  1186 VAQGPPKDGHGKQDPRKPSRRSTKRRRRTIAD-----ESAENVIDWWSKY---------YASVKR 1236

  Fly   252 CPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMI-SFYDSEGN--VPLHSA--VHG 311
            ..::..||     |:..:...:|..||.....:.....:::|: .....:||  :|..:|  ::.
Mouse  1237 AQKEKENN-----HKEKRATEAKPDEVVLDMEDGPKRKKDKMLKKKLKDDGNDAIPNLAALKIYD 1296

  Fly   312 GD-----------IKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEK---- 361
            ||           :|..||   ...|.:.:.|.|.....:...:|:..|.|     .|.:.
Mouse  1297 GDLESEFNNFEDWVKTFEL---FRGKSTEEDHGLDGDRVIGKFKGSFCIYK-----SPEDSTSED 1353

  Fly   362 --RLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLL 424
              :|.:.    |.:.|.|...:.    |..|:||      |.:       |..|...|....:::
Mouse  1354 SGQLRIQ----QGIPPNHPVQVL----IRVYIVA------AFN-------LSPADPDGKSDPYIV 1397

  Fly   425 IRLGAC-ISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPL----- 483
            :|||.. |..:|......|:.|.   ||  .|..| |....::.|.:|:.:.|.:|...|
Mouse  1398 LRLGKTEIKDRDKYIPKQLNPVF---GR--SFEIQ-ATFPKESLLSVLIYDHDMIGSDDLIGETK 1456

  Fly   484 -------------------------HYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 523
                                     :.|.||.. :..|.|.:|  |   |:|..:.| :|  |.|
Mouse  1457 IDLENRFYSKHRAICGLQSQYEIEGYNAWRDTS-KPTEILTKL--C---KDNKLDGP-YF--RPG 1512

  Fly   524 RYNTVRQLLDSEKGSFIINESDGAGMTPL--HISSQQGHT---------RVVQLLLNRGALLHRD 577
            :....:::.   .|..:.||.|...|...  |::.:..|:         |:|...:....|.|:|
Mouse  1513 KIQIGKKVF---SGKTVFNEEDSEEMVESYEHLALKVLHSWEDIPEAGWRLVPEHIETRPLYHKD 1574

  Fly   578 HTGRN--------------------PLQLAAM--SGYTETIELLHSVHSHLLDQ----------- 609
            ..|..                    |:.::..  .||...:.:.::....|.|:
Mouse  1575 KPGMEQGRLQMWVDMFPKDTPQLGPPVDISPRKPKGYELRVTIWNTEDVILEDENIFTGQKSSDI 1639

  Fly   610 ---------VDKDGNTALHLATME------------------------NKPHAISVLMSMGCK-- 639
                     .|....|.:|..::.                        :|...|..|..|.||
Mouse  1640 YVKGWIKGLEDDRQETDVHYNSLTGEGNFNWRFLFPFQYLPAEKQMVISKRENIFSLEKMECKTP 1704

  Fly   640 --LVYNVLD---MSAIDY-----AIYYKYPEAALAMVTHEERANEVMALRSDKHPCVTLALIASM 694
              ||..|.|   :|:.|:     .....:|.||.:                        |....:
Mouse  1705 AVLVLQVWDFERLSSDDFLGSLEMNLNSFPRAAKS------------------------AKACDL 1745

  Fly   695 PKVFEAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFAKIDEKTGE-----SITTA------- 747
            .|...|||:..|:....|:             ::..:.|||..|.||:     .:.||
Mouse  1746 SKFENAVQENKISIFQQKR-------------VRGWWPFAKSKELTGKVEAEFHLVTAEEAEKNP 1797

  Fly   748 ------SPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFLVFVTIY 805
                  .|.||...|...|  .......|....| .:.|.:|.||..:|.:||  |.:||:.::
Mouse  1798 VGKARKEPEPLAKPNRPDT--SFSWFVSPFKCLY-HLIWKNYKKYIIIAFILI--ILIVFLVLF 1856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560	18/106 (17%)
		ANK	121..246	CDD:238125	24/146 (16%)
		ANK repeat	125..155	CDD:293786	8/34 (24%)
		ANK repeat	157..199	CDD:293786	11/58 (19%)
		Ank_2	230..330	CDD:289560	18/115 (16%)
		ANK repeat	259..298	CDD:293786	6/39 (15%)
		ANK	298..425	CDD:238125	28/147 (19%)
		ANK repeat	300..330	CDD:293786	10/44 (23%)
		Ank_2	305..402	CDD:289560	22/115 (19%)
		ANK repeat	336..369	CDD:293786	5/38 (13%)
		ANK repeat	374..402	CDD:293786	7/27 (26%)
		ANK repeat	404..476	CDD:293786	17/72 (24%)
		ANK	473..599	CDD:238125	32/188 (17%)
		ANK repeat	478..509	CDD:293786	9/60 (15%)
		Ank_2	483..572	CDD:289560	23/129 (18%)
		ANK repeat	511..545	CDD:293786	7/33 (21%)
		ANK	542..662	CDD:238125	33/208 (16%)
		ANK repeat	547..576	CDD:293786	6/39 (15%)
		Ank_2	552..643	CDD:289560	24/171 (14%)
		ANK repeat	579..611	CDD:293786	6/73 (8%)
		ANK repeat	613..638	CDD:293786	6/48 (13%)
		Ion_trans	858..1074	CDD:278921
Fer1l6	NP_001357841.1	C2B_Ferlin	89..198	CDD:175978
		FerI	196..245	CDD:369715
		C2C_Ferlin	253..404	CDD:175985
		FerB	725..796	CDD:369714
		C2D_Ferlin	838..971	CDD:175984	13/29 (45%)
		C2E_Ferlin	1372..1495	CDD:176002	29/146 (20%)
		C2F_Ferlin	1612..1745	CDD:176020	21/156 (13%)
		Ferlin_C	1756..1868	CDD:374404	27/119 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900