DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and CG10011

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	163/611 - (26%)
Similarity:	244/611 - (39%)	Gaps:	128/611 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 RDQNGDFNAKD--------------NAGNTPLHI--AVESDAYDALDYLLSIPVDTGVLNEKKQA 193
            :.||.||...|              .||:...|.  ..||...:|...|..:.....:...|.:|
  Fly  1173 KSQNIDFELADLLLSSEKSCLMETQRAGSPSEHSEPPAESQDENASSTLHQLSDSHHIELHKGKA 1237

  Fly   194 PVH-LATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPC 257
            .:| ||.:.|.....|.:...::.||::....:|:|||::||...|.|..::|:: |.    :||
  Fly  1238 LIHILANDGNHQLLERALNACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLS-FS----QPC 1297

  Fly   258 NNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLK 322
            |:|                         .|..:...::..|.:|..||.||..||..:.|.|.:.
  Fly  1298 NDG-------------------------TGRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIA 1337

  Fly   323 SGA-KISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPD 386
            ..| ||.....:..|.:..|...|..||:||:     :|....::..|.|..|.|..||...|.|
  Fly  1338 QPACKIDLADKEGRTALRAAAWSGHEDILKLL-----IESGADVNSVDRQGRTSLIAASYMGHYD 1397

  Fly   387 IVSYLVAEGADINALDKEHRSPLLLAA--SRSGW-KTVHLLIRLGACISVKDAAARNVLHFVIMN 448
            ||..|:..||::|.||.:.||.|.:||  ..||: |.:..|:..||.....|            |
  Fly  1398 IVEILLENGANVNHLDLDGRSALCVAALCGSSGYSKVISTLLDHGANTDQLD------------N 1450

  Fly   449 GGR----LTDFAEQVANCQTQAQLKLLLNE------KDSMGCSPLHYASRDGHIRSLENLIRLGA 503
            .|.    ::.|......|:      |||..      .|.||.:||..|...||...::.|:..|.
  Fly  1451 DGMSPLLVSSFEGNAEVCE------LLLENAADPDLADFMGRTPLWAACTAGHATVVKLLLFWGC 1509

  Fly   504 CINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINES--DGAGMTPLHISSQQGHTRVVQL 566
            .|:..::...:.|...|..|...|||||||  :|   ::|:  |.||.||||.::.:|...|...
  Fly  1510 GIDCMDSEGRTVLSIGAAQGNVETVRQLLD--RG---LDETHRDNAGWTPLHYAAFEGFHEVCLQ 1569

  Fly   567 LLNRGALLHR-DHTGRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAI 630
            ||..||.:.. |:.|:..|.|||..|....::.|..:||..:||...||.||..||.:|.....:
  Fly  1570 LLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGHMDTV 1634

  Fly   631 SVLMSMGC----------------------KLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERAN 673
            ..|:...|                      ::|..:|||:.:|..|.......||.:...:..|:
  Fly  1635 EFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQGHAD 1699

  Fly   674 EVMAL--------------RSDKHPC 685
            .|..|              |:..|.|
  Fly  1700 MVKTLIEAGADVNSMDLEARTPLHSC 1725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560	12/58 (21%)
		ANK	121..246	CDD:238125	29/117 (25%)
		ANK repeat	125..155	CDD:293786	4/9 (44%)
		ANK repeat	157..199	CDD:293786	11/44 (25%)
		Ank_2	230..330	CDD:289560	25/100 (25%)
		ANK repeat	259..298	CDD:293786	2/38 (5%)
		ANK	298..425	CDD:238125	45/130 (35%)
		ANK repeat	300..330	CDD:293786	12/30 (40%)
		Ank_2	305..402	CDD:289560	32/97 (33%)
		ANK repeat	336..369	CDD:293786	8/32 (25%)
		ANK repeat	374..402	CDD:293786	12/27 (44%)
		ANK repeat	404..476	CDD:293786	19/84 (23%)
		ANK	473..599	CDD:238125	43/134 (32%)
		ANK repeat	478..509	CDD:293786	10/30 (33%)
		Ank_2	483..572	CDD:289560	30/90 (33%)
		ANK repeat	511..545	CDD:293786	12/35 (34%)
		ANK	542..662	CDD:238125	41/144 (28%)
		ANK repeat	547..576	CDD:293786	12/28 (43%)
		Ank_2	552..643	CDD:289560	30/113 (27%)
		ANK repeat	579..611	CDD:293786	11/31 (35%)
		ANK repeat	613..638	CDD:293786	8/24 (33%)
		Ion_trans	858..1074	CDD:278921
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	16/53 (30%)
		ANK	1266..1403	CDD:238125	46/171 (27%)
		ANK repeat	1270..1313	CDD:293786	15/72 (21%)
		Ank_2	1275..1380	CDD:289560	33/139 (24%)
		ANK repeat	1315..1347	CDD:293786	12/31 (39%)
		ANK repeat	1349..1380	CDD:293786	8/35 (23%)
		Ank_2	1354..1449	CDD:289560	34/99 (34%)
		ANK repeat	1382..1413	CDD:293786	13/30 (43%)
		ANK	1410..1538	CDD:238125	40/145 (28%)
		ANK repeat	1415..1446	CDD:293786	11/30 (37%)
		Ank_5	1438..1489	CDD:290568	14/68 (21%)
		ANK	1479..1604	CDD:238125	43/129 (33%)
		ANK repeat	1484..1515	CDD:293786	10/30 (33%)
		Ank_2	1489..1581	CDD:289560	32/96 (33%)
		ANK repeat	1517..1548	CDD:293786	12/35 (34%)
		ANK repeat	1550..1581	CDD:293786	12/30 (40%)
		Ank_2	1555..1648	CDD:289560	29/92 (32%)
		ANK	1578..1705	CDD:238125	31/126 (25%)
		ANK repeat	1617..1648	CDD:293786	9/30 (30%)
		Ank_2	1624..1715	CDD:289560	16/90 (18%)
		ANK	1645..1771	CDD:238125	14/81 (17%)
		ANK repeat	1650..1682	CDD:293786	6/31 (19%)
		ANK repeat	1684..1715	CDD:293786	5/30 (17%)
		Ank_2	1689..1781	CDD:289560	7/37 (19%)
		ANK repeat	1717..1742	CDD:293786	3/9 (33%)
		ANK repeat	1750..1775	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24123
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010