DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and wtrw

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_731193.1	Gene:	wtrw / 40931	FlyBaseID:	FBgn0260005	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	984	Identity:	213/984 - (21%)
Similarity:	377/984 - (38%)	Gaps:	279/984 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 ISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQP 358
            :.|.|..|...||.:...|.:..:.|.:..|..::.|. ...||:|.|....|.:..||:..
  Fly   176 LHFCDQNGISALHLSAFSGCLATLGLLVAKGLNVNLQS-KCYTPLHCAAFGNAAEAAKLLIN--- 236

  Fly   359 MEKRLCLSCTDVQKMTP--------LHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASR 415
                   :..|:.|.|.        ||||...:..:.:...:|||||:|:|            ..
  Fly   237 -------NGADISKDTSKPNCEESLLHCAVRSNALECLQIFIAEGADVNSL------------KP 282

  Fly   416 SGWKTVHLLIRLG--ACISVKDAAARNVLHFVIMNGGRLTDFAEQVANC-QTQAQLKLLLNEKDS 477
            :|...:||...||  .|:                         |.:.|. ...|.:::.:.||:|
  Fly   283 NGTNAIHLAADLGNIQCL-------------------------EALLNAPNADANVRICIREKES 322

  Fly   478 MGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIIN 542
               :.||.|:.:|::..::.|:..||...|||:...:|||.|||....:.|..||  ..|:...|
  Fly   323 ---TALHLAADEGNVECVDLLLAKGADAKLKNHRGFTPLHLAARTSSLDCVESLL--RNGNADAN 382

  Fly   543 ESDGAGMTPLH--ISSQQGHTRVVQLLLNRGA-LLHRDHTGRNPLQLAAMSGYTETIELLHSVHS 604
            ..|....||||  :...:....:::.|:..|| :.|:|..|...|.|||:.|..:.:|:| ..|.
  Fly   383 AEDFDHRTPLHAAVGKSENAYDIMETLIQWGANVNHKDIYGFTALHLAALDGLVQCVEML-IFHG 446

  Fly   605 HLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAALAMVTHE 669
            ..:....|.|.:||::.|.:. |.:::::..   ||                   :||:.:...:
  Fly   447 ADVTTKSKKGTSALNVITRKT-PASVAMIRQ---KL-------------------DAAITLHHSQ 488

  Fly   670 ERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFA 734
            :..|..:.|..|                |..:...|
  Fly   489 DPVNREVELELD----------------FRQLLQHC----------------------------- 508

  Fly   735 KIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFL 799
                         .|..:..|||.|..|:.|:|.|||...:|.:||....||: :..|:....|:
  Fly   509 -------------HPREISYLNTFVDEGQKEILEHPLCSSFLYIKWGKIRKYY-IGRLIFCFSFV 559

  Fly   800 VFVTIY--SSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSV-ASQIRLDSCEERINRTT 861
            :|:|:|  ::|..|.......||.|:.          ...|.|..|: ...:|        |...
  Fly   560 LFLTLYVLTALAHNCYNGSKNDNTTIP----------AQELCQKQSILGDMLR--------NNPF 606

  Fly   862 AILFCAVVIVVYILLNSMRELIQI--YQQKLHYILETVNLISWVLYISALVM------VTPAFQP 918
            .:.....|:|...::...|:|..|  |....||:.:..|::.|.:..|..|:      .|..||.
  Fly   607 VMEMQWWVLVAITIVEIFRKLYGITGYSSFRHYVTQVENIMEWFVITSVFVISYIYTNKTYTFQN 671

  Fly   919 DGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAF 983
            ..|         :.||.|.|..|:|.:.:.....:||.|:..:.....|:.|.:|.::|.|.::|
  Fly   672 HIG---------AFAVLLGWTNLMLMIGQLPVFDVYVAMYTRVQGEFAKLFMAYSCMLIGFTISF 727

  Fly   984 YILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRDQLKVP-----MTSFLIL 1043
            .::.       |:..||:|..|..:....||:||.| :...:|.   .:.|.|     :::.:..
  Fly   728 CVIF-------PSSSSFANPFMGFITVLVMMIGEQD-LSLLIND---PEGKDPPFLLEVSAQITF 781

  Fly  1044 SVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPH----VWLQRVDKME 1104
            .:|::.:.|:|||||:|:||.||:.:::.|.|.:|..|..|.:.:|..|.:    .||:     .
  Fly   782 VLFLLFVTIILMNLLVGIAVHDIQGLKKTAGLSKLVRQTKLISYIESALFNGYLPTWLR-----N 841

  Fly  1105 LIEY-------------------PNETKC---------KLGFCDFILRKWFSNPF-TEDSSMDVI 1140
            |:.|                   |:|.:.         ::|    .:||.|.:.. :::|:.:.:
  Fly   842 LLHYTALVSPQAYRVVLCVKPLNPSEKRLPREILMKAYEVG----KMRKHFGHTISSKNSAENYL 902

  Fly  1141 SFDNN------------------------------DDYINAE-LERQRRKLRDISRMLEQQHHLV 1174
            |:.|.                              ||  ||: :|...::::::.:.|..|....
  Fly   903 SYKNKYNNNNGATTGYVLPDSDPDAGQFTTLTTKIDD--NADRIEFLTQEIQELKQALISQQQQA 965

  Fly  1175 RLIVQKMEI 1183
            ..::.|:.|
  Fly   966 SKVIDKLLI 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560
		ANK	121..246	CDD:238125
		ANK repeat	125..155	CDD:293786
		ANK repeat	157..199	CDD:293786
		Ank_2	230..330	CDD:289560	8/35 (23%)
		ANK repeat	259..298	CDD:293786	1/3 (33%)
		ANK	298..425	CDD:238125	32/134 (24%)
		ANK repeat	300..330	CDD:293786	6/29 (21%)
		Ank_2	305..402	CDD:289560	26/104 (25%)
		ANK repeat	336..369	CDD:293786	7/32 (22%)
		ANK repeat	374..402	CDD:293786	11/35 (31%)
		ANK repeat	404..476	CDD:293786	10/74 (14%)
		ANK	473..599	CDD:238125	41/128 (32%)
		ANK repeat	478..509	CDD:293786	8/30 (27%)
		Ank_2	483..572	CDD:289560	27/90 (30%)
		ANK repeat	511..545	CDD:293786	11/33 (33%)
		ANK	542..662	CDD:238125	28/122 (23%)
		ANK repeat	547..576	CDD:293786	7/31 (23%)
		Ank_2	552..643	CDD:289560	24/93 (26%)
		ANK repeat	579..611	CDD:293786	9/31 (29%)
		ANK repeat	613..638	CDD:293786	5/24 (21%)
		Ion_trans	858..1074	CDD:278921	57/228 (25%)
wtrw	NP_731193.1	Ank_2	156..241	CDD:289560	16/75 (21%)
		ANK repeat	182..213	CDD:293786	6/30 (20%)
		ANK repeat	215..242	CDD:293786	8/36 (22%)
		ANK	216..341	CDD:238125	37/174 (21%)
		ANK repeat	250..281	CDD:293786	11/42 (26%)
		Ank_2	255..351	CDD:289560	31/135 (23%)
		ANK repeat	283..317	CDD:293786	9/58 (16%)
		ANK	323..443	CDD:238125	39/122 (32%)
		ANK repeat	323..351	CDD:293786	8/27 (30%)
		Ank_2	325..420	CDD:289560	30/96 (31%)
		ANK repeat	353..385	CDD:293786	11/33 (33%)
		ANK repeat	387..420	CDD:293786	8/32 (25%)
		Ank_2	392..>460	CDD:289560	18/68 (26%)
		ANK repeat	422..452	CDD:293786	9/30 (30%)
		Ion_trans	613..812	CDD:278921	56/218 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D180347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820