DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and pain

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_611979.1	Gene:	pain / 37985	FlyBaseID:	FBgn0060296	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	827	Identity:	165/827 - (19%)
Similarity:	280/827 - (33%)	Gaps:	270/827 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 LKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLH-------- 377
            |.|.||..|   |.:.|...:|.|..:|     :...|       :..|..:.||||
  Fly   119 LNSLAKNLT---DENAPDVYSCMQLLLD-----YGASP-------NIVDQGEFTPLHHVLRKSKV 168

  Fly   378 ------CASMF-DHP--DIVSY--------LVAEGADINALDKEHRSP-----LLLAASRSGWKT 420
                  ...:| |||  ||.||        |.|:..::...::.|..|     .|....|.|.:|
  Fly   169 KAGKKELIQLFLDHPELDIDSYRNGEVRRLLQAQFPELKLPEERHTGPEIDIQTLQRTLRDGDET 233

  Fly   421 VHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSPLHY 485
            :.                             ...|||.:.|.:..|..:|..::::..|.  |..
  Fly   234 LF-----------------------------EQQFAEYLQNLKGGADNQLNAHQEEYFGL--LQE 267

  Fly   486 ASRDGHIRSLENLIRLGACINLK-NNNNESPL-HFAARYGRYNTVRQLL---------DSEKGSF 539
            :.:.|..|:.:.::..|..||.: ...||:.| ..|..||.:..:.:||         ||:..:.
  Fly   268 SIKRGRQRAFDVILSTGMDINSRPGRANEANLVETAVIYGNWQALERLLKEPNLRLTPDSKLLNA 332

  Fly   540 IINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAAMSGYTETIELLHSVHS 604
            :|...|    .|.:..|  .|.|..:||:|                       ::.::
  Fly   333 VIGRLD----EPPYDGS--SHQRCFELLIN-----------------------SDRVD------- 361

  Fly   605 HLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAALAMVTHE 669
              :::.|......|..|.......|:..|:..|
  Fly   362 --INEADSGRLVPLFFAVKYRNTSAMQKLLKNG-------------------------------- 392

  Fly   670 ERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFA 734
                   |....|....||.:....|:|.|...|.|||....:...::|.|...:..|    |..
  Fly   393 -------AYIGSKSAFGTLPIKDMPPEVLEEHFDSCITTNGERPGDQNFEIIIDYKNL----MRQ 446

  Fly   735 KIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFL 799
            :.|....:.....:||...|.:..:.|    ||.|||...:|.:||:.....|:| |.||||:|.
  Fly   447 ERDSGLNQLQDEMAPIAFIAESKEMRH----LLQHPLISSFLFLKWHRLSVIFYL-NFLIYSLFT 506

  Fly   800 VFVTIYSSLMMNNIELKAGDNKTMSQYCN-MGWEQLTMNLSQNPSVASQIRLDSCEERINRTTAI 863
            ..:..|:.|..:.     .|.:.::.:.. :.|    :.:|
  Fly   507 ASIITYTLLKFHE-----SDQRALTAFFGLLSW----LGIS------------------------ 538

  Fly   864 LFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLY-ISALVMVTPAFQPDGGINTIHY 927
                     |::|   ||.||.....:.|.....|::...|. :|....:..:|..:
  Fly   539 ---------YLIL---RECIQWIMSPVRYFWSITNIMEVALITLSIFTCMESSFDKE-------- 583

  Fly   928 SAASIAVFLSWFRLLLFLQRFD---------QVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAF 983
            :...:||    |.:||....|.         .:..:::|..|:..:.:|...::||.::.|.|.|
  Fly   584 TQRVLAV----FTILLVSMEFCLLVGSLPVLSISTHMLMLREVSNSFLKSFTLYSIFVLTFSLCF 644

  Fly   984 YILLSKII--------------------DPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTY 1028
            |||..|.:                    |.:....:|:....::::|..|:.||.|.......:.
  Fly   645 YILFGKSVEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLTGEFDAGSIQFTSI 709

  Fly  1029 YRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQL 1075
            |         ::||..:|:|.|.|:|.|||.||||.|.:.::..|:|
  Fly   710 Y---------TYLIFLLFVIFMTIVLFNLLNGLAVSDTQVIKAQAEL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560
		ANK	121..246	CDD:238125
		ANK repeat	125..155	CDD:293786
		ANK repeat	157..199	CDD:293786
		Ank_2	230..330	CDD:289560	4/8 (50%)
		ANK repeat	259..298	CDD:293786
		ANK	298..425	CDD:238125	32/133 (24%)
		ANK repeat	300..330	CDD:293786	4/8 (50%)
		Ank_2	305..402	CDD:289560	26/105 (25%)
		ANK repeat	336..369	CDD:293786	5/32 (16%)
		ANK repeat	374..402	CDD:293786	14/52 (27%)
		ANK repeat	404..476	CDD:293786	12/76 (16%)
		ANK	473..599	CDD:238125	26/136 (19%)
		ANK repeat	478..509	CDD:293786	7/31 (23%)
		Ank_2	483..572	CDD:289560	25/99 (25%)
		ANK repeat	511..545	CDD:293786	11/43 (26%)
		ANK	542..662	CDD:238125	14/119 (12%)
		ANK repeat	547..576	CDD:293786	7/28 (25%)
		Ank_2	552..643	CDD:289560	12/90 (13%)
		ANK repeat	579..611	CDD:293786	0/31 (0%)
		ANK repeat	613..638	CDD:293786	4/24 (17%)
		Ion_trans	858..1074	CDD:278921	52/245 (21%)
pain	NP_611979.1	ANK	56..180	CDD:238125	16/75 (21%)
		ANK repeat	82..111	CDD:293786
		ANK repeat	113..152	CDD:293786	11/47 (23%)
		ANK	303..406	CDD:238125	26/179 (15%)
		Ank_2	303..398	CDD:289560	23/171 (13%)
		ANK repeat	324..366	CDD:293786	11/79 (14%)
		ANK repeat	368..393	CDD:293786	5/63 (8%)
		Ion_trans	525..746	CDD:278921	54/281 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810