DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and SOWAHD

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_001099046.1 Gene:SOWAHD / 347454 HGNCID:32960 Length:315 Species:Homo sapiens


Alignment Length:218 Identity:54/218 - (24%)
Similarity:94/218 - (43%) Gaps:45/218 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   400 ALDKEHRSP--LLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANC 462
            |..:||..|  |:.:|:.||.:...|...||    ::.||..         |....:.||::...
Human    49 AASREHPFPGTLMHSAAGSGRRRGALRELLG----LQRAAPA---------GWLSEERAEELGGP 100

  Fly   463 QTQAQLKLLLNEKDSMGCSPLH---YASRDGHIRSLENLIRLGACINLKNN--NNESPLHFAARY 522
            ......:|.|..::       |   .|:.:|....|..|:.....:.|:.:  ...|.||:.|::
Human   101 SGPGSSRLCLEPRE-------HAWILAAAEGRYEVLRELLEAEPELLLRGDPITGYSVLHWLAKH 158

  Fly   523 GRYNTVRQLLD--SEKGSFI-INESDGAGMTPLHISSQQGHTRVVQLLLNRGAL----LHRDHTG 580
            ||:..:..:.|  ..:|..: ::.....|:||||:::.|||..|:::|:  |||    ..|||:|
Human   159 GRHEELILVHDFALRRGLRLDVSAPGSGGLTPLHLAALQGHDMVIKVLV--GALGADATRRDHSG 221

  Fly   581 RN---------PLQLAAMSGYTE 594
            ..         |.:|..:||..|
Human   222 HRACHYLRPDAPWRLRELSGAEE 244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560
ANK 121..246 CDD:238125
ANK repeat 125..155 CDD:293786
ANK repeat 157..199 CDD:293786
Ank_2 230..330 CDD:289560
ANK repeat 259..298 CDD:293786
ANK 298..425 CDD:238125 9/26 (35%)
ANK repeat 300..330 CDD:293786
Ank_2 305..402 CDD:289560 1/1 (100%)
ANK repeat 336..369 CDD:293786
ANK repeat 374..402 CDD:293786 1/1 (100%)
ANK repeat 404..476 CDD:293786 17/73 (23%)
ANK 473..599 CDD:238125 36/143 (25%)
ANK repeat 478..509 CDD:293786 6/33 (18%)
Ank_2 483..572 CDD:289560 24/96 (25%)
ANK repeat 511..545 CDD:293786 8/36 (22%)
ANK 542..662 CDD:238125 22/66 (33%)
ANK repeat 547..576 CDD:293786 13/32 (41%)
Ank_2 552..643 CDD:289560 19/56 (34%)
ANK repeat 579..611 CDD:293786 6/25 (24%)
ANK repeat 613..638 CDD:293786
Ion_trans 858..1074 CDD:278921
SOWAHDNP_001099046.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
ANK 1 112..141 5/35 (14%)
ANK 147..>231 CDD:238125 25/85 (29%)
ANK 2 147..162 6/14 (43%)
Ank_2 <148..218 CDD:289560 21/71 (30%)
ANK repeat 148..184 CDD:293786 8/35 (23%)
ANK repeat 186..218 CDD:293786 13/33 (39%)
ANK 3 186..216 13/31 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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