DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and Trpa1

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_997491.1 Gene:Trpa1 / 312896 RGDID:1303284 Length:1125 Species:Rattus norvegicus


Alignment Length:1132 Identity:388/1132 - (34%)
Similarity:619/1132 - (54%) Gaps:113/1132 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 ESGNLD---DFKRL--FMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGD----FNAKD 155
            ||..:|   |..||  |:.:..:::..:.:.....|.|||..:|.:::.|  .||.    .|..|
  Rat    34 ESFKVDIEGDMCRLEAFIKNRRKLSKYEDENLCLLHHAAAEGQVELMQLI--INGSSCEALNVMD 96

  Fly   156 NAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVI--- 217
            :.||||||.|.|.:..:::.:|||...:..:.|....||:|:|          |.|.|..||   
  Rat    97 DYGNTPLHWAAEKNQVESVKFLLSQGANPNLRNRNMMAPLHIA----------VQGMYNEVIKVL 151

  Fly   218 ------DIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNN---GYYPIHEAAKNASS 273
                  :|...||:|.|||......|:.|..:||:.:    ..|.|.:   |.||:|:||.:.:.
  Rat   152 TEHKATNINLEGENGNTALMSTCAKDNSEALQILLEK----GAKLCKSNKWGDYPVHQAAFSGAK 212

  Fly   274 KTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTPV 338
            :.||:...:||:.|.:||..|:|.:.:...|||.||..||:..:::||.|||.|...::.....:
  Rat   213 RCMELILAYGEKTGYSREAHINFVNHKKASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMAL 277

  Fly   339 HLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDK 403
            |.|..|||.||||||.........: ::..|..:.|.||.||:|||.|:..||::.|||||:.|.
  Rat   278 HFAATQGATDIVKLMISSYTGSSDI-VNAVDGNQETLLHRASLFDHHDLADYLISVGADINSTDS 341

  Fly   404 EHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQL 468
            |.||||:||.:.:.|..|:||:..||.:.:||...||.||..:.....|.:...:....|   .:
  Rat   342 EGRSPLILATASASWNIVNLLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPEFLQMQ---HI 403

  Fly   469 KLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLLD 533
            |.|:.::|:.||:|||||.|.|...|:.||:|....::.|:.:.:|||||||.|||.||.::||.
  Rat   404 KELVMDEDNDGCTPLHYACRQGAPVSVNNLLRFNVSVHSKSKDKKSPLHFAASYGRINTCQRLLQ 468

  Fly   534 SEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAAMSGYTETIEL 598
            ....:.::||.|..||||||::::.||.:||||||.:|||...||.|...|..|:|.|||:|:::
  Rat   469 DISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKV 533

  Fly   599 LHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAAL 663
            :...:....|::|::||||||.|..|....|:::|:|....::.|....|.:..|::.|..|..|
  Rat   534 ILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIALHNKRKEVVL 598

  Fly   664 AMVTHEERANEVMALRSDKHP---CVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFA 725
            ..: ..:|.:|.:.:.:...|   |..:.::..:|:..:.:.|.|:..:...|..:.::|:|:|.
  Rat   599 TTI-RSKRWDECLQVFTHDSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYNFK 662

  Fly   726 FLQCPFMFAKIDEKTGESITTASPI---PLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYF 787
            :||||....|       .:|....:   ||..||.||.|.|:|||.||:.::||.|||.:||...
  Rat   663 YLQCPLSMTK-------KVTPTQDVIYEPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRA 720

  Fly   788 HLANLLIYSIFLV-----FVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASQ 847
            |:.||..|.:.|:     .|.|...:..|:..:   .|:|:|.:                     
  Rat   721 HMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGI---INETISTH--------------------- 761

  Fly   848 IRLDSCEERINRTTA--ILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYISALV 910
                  |||||...:  :..|.:::.:..:....:|::||:|||.:|.|:..|.:.||:|.::::
  Rat   762 ------EERINTLNSFPLKICMILVFLSSIFGYCKEVVQIFQQKRNYFLDYNNALEWVIYTTSMI 820

  Fly   911 MVTPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSIL 975
            .|.|.|......  :.:...:||:|..|...||:||||:..||::||...|.:||::...||..|
  Rat   821 FVLPLFLDIPAY--MQWQCGAIAIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLLRSTGVFIFL 883

  Fly   976 IIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRDQLKVPMTSF 1040
            ::||||:||:||: ..|      :||...:||::|||||||::::...::...:|::|..|:.:|
  Rat   884 LLAFGLSFYVLLN-FQD------AFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRNELAYPVLTF 941

  Fly  1041 LILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQRVDKMEL 1105
            ..|..|.:.:||:|||||||||||||..|:::|.|||:||||.|||.||:|||..:|::||:...
  Rat   942 GQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPFWYLRKVDQRST 1006

  Fly  1106 IEYPNETK--CKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRKLRDISRMLE 1168
            |.|||..:  ..|.|..:.|.       .:::..:.   .|.|..:..|:.:|:.:|:|::.:||
  Rat  1007 IVYPNRPRHGRMLRFFHYFLS-------MQETRQEA---PNIDTCLEMEILKQKYRLKDLTSLLE 1061

  Fly  1169 QQHHLVRLIVQKMEIKTEADDVDEGIS 1195
            :||.|::||:|||||.:|.:|.|...|
  Rat  1062 KQHELIKLIIQKMEIISETEDEDNHCS 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 28/96 (29%)
ANK 121..246 CDD:238125 41/137 (30%)
ANK repeat 125..155 CDD:293786 9/33 (27%)
ANK repeat 157..199 CDD:293786 15/41 (37%)
Ank_2 230..330 CDD:289560 35/102 (34%)
ANK repeat 259..298 CDD:293786 15/41 (37%)
ANK 298..425 CDD:238125 52/126 (41%)
ANK repeat 300..330 CDD:293786 13/29 (45%)
Ank_2 305..402 CDD:289560 40/96 (42%)
ANK repeat 336..369 CDD:293786 11/32 (34%)
ANK repeat 374..402 CDD:293786 16/27 (59%)
ANK repeat 404..476 CDD:293786 23/71 (32%)
ANK 473..599 CDD:238125 59/125 (47%)
ANK repeat 478..509 CDD:293786 13/30 (43%)
Ank_2 483..572 CDD:289560 42/88 (48%)
ANK repeat 511..545 CDD:293786 16/33 (48%)
ANK 542..662 CDD:238125 48/119 (40%)
ANK repeat 547..576 CDD:293786 17/28 (61%)
Ank_2 552..643 CDD:289560 36/90 (40%)
ANK repeat 579..611 CDD:293786 9/31 (29%)
ANK repeat 613..638 CDD:293786 11/24 (46%)
Ion_trans 858..1074 CDD:278921 79/217 (36%)
Trpa1NP_997491.1 ANK 1 63..94 8/32 (25%)
Ank_2 83..>373 CDD:393464 109/306 (36%)
ANK repeat 98..129 CDD:293786 11/30 (37%)
ANK 2 98..127 11/28 (39%)
ANK repeat 131..163 CDD:293786 10/41 (24%)
ANK 3 131..161 10/39 (26%)
ANK 4 165..194 9/32 (28%)
ANK repeat 165..190 CDD:293786 8/28 (29%)
ANK repeat 198..237 CDD:293786 15/38 (39%)
ANK 5 198..227 10/28 (36%)
ANK repeat 239..268 CDD:293786 13/28 (46%)
ANK 6 239..268 13/28 (46%)
ANK 7 272..301 11/28 (39%)
ANK repeat 276..307 CDD:293786 11/31 (35%)
ANK repeat 309..340 CDD:293786 16/30 (53%)
ANK 8 309..338 15/28 (54%)
ANK repeat 342..373 CDD:293786 13/30 (43%)
ANK 9 342..371 13/28 (46%)
ANK repeat 413..444 CDD:293786 13/30 (43%)
ANK 10 413..442 13/28 (46%)
Ank_2 418..507 CDD:372319 42/88 (48%)
ANK repeat 446..480 CDD:293786 16/33 (48%)
ANK 11 446..475 14/28 (50%)
ANK repeat 482..512 CDD:293786 17/29 (59%)
ANK 12 482..511 17/28 (61%)
Ank_2 487..578 CDD:372319 36/90 (40%)
ANK repeat 514..546 CDD:293786 9/31 (29%)
ANK 13 514..543 8/28 (29%)
ANK 14 548..577 11/28 (39%)
ANK repeat 548..573 CDD:293786 11/24 (46%)
Ion_trans <799..975 CDD:366146 72/184 (39%)
Inositolphosphate binding. /evidence=ECO:0000250|UniProtKB:O75762 1048..1054 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335605
Domainoid 1 1.000 151 1.000 Domainoid score I4262
eggNOG 1 0.900 - - E2759_KOG0510
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7189
Inparanoid 1 1.050 641 1.000 Inparanoid score I784
OMA 1 1.010 - - QHG46546
OrthoDB 1 1.010 - - D180347at33208
OrthoFinder 1 1.000 - - FOG0006155
OrthoInspector 1 1.000 - - oto98576
orthoMCL 1 0.900 - - OOG6_104949
Panther 1 1.100 - - LDO PTHR24123
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X5089
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.770

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