DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and ANK3

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_066267.2	Gene:	ANK3 / 288	HGNCID:	494	Length:	4377	Species:	Homo sapiens

Alignment Length:	730	Identity:	178/730 - (24%)
Similarity:	307/730 - (42%)	Gaps:	129/730 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IFSMIIERSAGPKRIEIDGDDADTPLEAILPA--------EPPAEVCLLRD------------SP 92
            :.|:::|.              ||..:..|||        :..|...||::            :|
Human   188 VVSLLLEN--------------DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238

  Fly    93 FRILRAAESGNLDDFKRLFMADNSRIALKDAKGR---TAAHQAAARNRVNILRYIRDQNGDFNAK 154
            ..|  ||..||::....|.    :|.|..|...|   |..|.|:.|...|:::.:.|:....:||
Human   239 LHI--AAHYGNINVATLLL----NRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297

  Fly   155 DNAGNTPLHIAVESDAYDALDYLL--SIPVDTGVLNEKKQ--APVHLATELNKVKSLRVMGQYRN 215
            ...|.||||....|.....::.||  :.|    :|::.|.  :|:|:||:.:.:..::::.|:.
Human   298 TRDGLTPLHCGARSGHEQVVEMLLDRAAP----ILSKTKNGLSPLHMATQGDHLNCVQLLLQHN- 357

  Fly   216 VIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFF 280
             :.:........||||:||...|.:.|::|:.: .|.|.....||:.|:|.|.|....|.||:..
Human   358 -VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK-KANPNAKALNGFTPLHIACKKNRIKVMELLL 420

  Fly   281 QWG------EQRGCTREEMISFY-------------------DSEGNVPLHSAVHGGDIKAVELC 320
            :.|      .:.|.|...:.:|.                   :..|...||.|...|..:.|...
Human   421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485

  Fly   321 LKSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHP 385
            ::.||::..:..|..||:|::...|..|||:     |.:::....:.......||||.::...|.
Human   486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQ-----QLLQQGASPNAATTSGYTPLHLSAREGHE 545

  Fly   386 DIVSYLVAEGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARN---VLHFVIM 447
            |:.::|:..||.::...|:..:||.:||.....:..:||::..|.   .|||.::   .||.
Human   546 DVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS---PDAAGKSGLTPLHV--- 604

  Fly   448 NGGRLTDFAEQVANCQTQAQLKLLLNEKDS------MGCSPLHYASRDGHIRSLENLIRLGACIN 506
                       .|:...|....|||::..|      .|.:|||.|::...:.....|:..||..|
Human   605 -----------AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658

  Fly   507 LKNNNNESPLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRG 571
            .......:.:|.||:.|..:.|..||.....   :|.|:.:|:||||:::|:....|.::|:|:|
Human   659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720

  Fly   572 ALLHRD---HTGRNPLQLAAMSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVL 633
            |  |.|   ..|..||.:....|..:.:..|.. ||..::...|:|.|.||.|..:...|.|:||
Human   721 A--HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ-HSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782

  Fly   634 MSMGC---KLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKHPCVTLALIASMP 695
            :....   :|..|......|...:.|......|.:||.|......:   ::||   .:.:..:|.
Human   783 LQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTV---TEKH---KMNVPETMN 841

  Fly   696 KVFEAVQDKCITKAN 710
            :|.:...|: :.|||
Human   842 EVLDMSDDE-VRKAN 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560	27/97 (28%)
		ANK	121..246	CDD:238125	34/131 (26%)
		ANK repeat	125..155	CDD:293786	8/32 (25%)
		ANK repeat	157..199	CDD:293786	13/45 (29%)
		Ank_2	230..330	CDD:289560	30/124 (24%)
		ANK repeat	259..298	CDD:293786	13/63 (21%)
		ANK	298..425	CDD:238125	32/126 (25%)
		ANK repeat	300..330	CDD:293786	8/29 (28%)
		Ank_2	305..402	CDD:289560	25/96 (26%)
		ANK repeat	336..369	CDD:293786	8/32 (25%)
		ANK repeat	374..402	CDD:293786	9/27 (33%)
		ANK repeat	404..476	CDD:293786	17/74 (23%)
		ANK	473..599	CDD:238125	36/134 (27%)
		ANK repeat	478..509	CDD:293786	9/30 (30%)
		Ank_2	483..572	CDD:289560	25/88 (28%)
		ANK repeat	511..545	CDD:293786	8/33 (24%)
		ANK	542..662	CDD:238125	36/125 (29%)
		ANK repeat	547..576	CDD:293786	11/28 (39%)
		Ank_2	552..643	CDD:289560	28/96 (29%)
		ANK repeat	579..611	CDD:293786	7/31 (23%)
		ANK repeat	613..638	CDD:293786	9/24 (38%)
		Ion_trans	858..1074	CDD:278921
ANK3	NP_066267.2	ANK 6	234..263		9/34 (26%)
		ANK repeat	267..298	CDD:293786	7/30 (23%)
		ANK 7	267..296		6/28 (21%)
		Ank_2	272..363	CDD:289560	23/96 (24%)
		ANK	295..420	CDD:238125	38/131 (29%)
		ANK 8	300..329		9/32 (28%)
		ANK repeat	300..325	CDD:293786	8/24 (33%)
		ANK repeat	333..364	CDD:293786	5/32 (16%)
		ANK 9	333..362		5/30 (17%)
		ANK	361..486	CDD:238125	30/125 (24%)
		ANK 10	366..395		11/29 (38%)
		ANK repeat	369..397	CDD:293786	11/28 (39%)
		Ank_2	371..463	CDD:289560	22/92 (24%)
		ANK repeat	399..430	CDD:293786	10/30 (33%)
		ANK 11	399..428		10/28 (36%)
		ANK repeat	432..463	CDD:293786	3/30 (10%)
		ANK 12	432..461		3/28 (11%)
		ANK	460..585	CDD:238125	32/129 (25%)
		ANK repeat	465..496	CDD:293786	8/30 (27%)
		ANK 13	465..494		8/28 (29%)
		Ank_2	470..561	CDD:289560	25/95 (26%)
		ANK repeat	498..529	CDD:293786	9/35 (26%)
		ANK 14	498..527		9/33 (27%)
		ANK repeat	531..560	CDD:293786	9/28 (32%)
		ANK 15	531..560		9/28 (32%)
		Ank_2	536..626	CDD:289560	26/106 (25%)
		ANK	560..684	CDD:238125	33/140 (24%)
		ANK repeat	564..593	CDD:293786	7/31 (23%)
		ANK 16	564..593		7/31 (23%)
		ANK repeat	597..626	CDD:293786	8/42 (19%)
		ANK 17	597..626		8/42 (19%)
		ANK repeat	630..660	CDD:293786	9/29 (31%)
		ANK 18	630..659		8/28 (29%)
		Ank_4	631..684	CDD:290365	14/52 (27%)
		ANK	658..783	CDD:238125	39/130 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Ank_4	47..94	CDD:290365
		ANK	68..193	CDD:238125	1/4 (25%)
		ANK repeat	73..104	CDD:293786
		ANK 1	73..102
		Ank_2	78..164	CDD:289560
		ANK repeat	106..137	CDD:293786
		ANK 2	106..135
		ANK 3	139..168
		ANK repeat	139..164	CDD:293786
		Ank_4	140..193	CDD:290365	1/4 (25%)
		ANK 4	172..201		4/26 (15%)
		ANK 5	203..230		6/26 (23%)
		ANK repeat	205..232	CDD:293786	4/26 (15%)
		Ank_2	206..297	CDD:289560	20/96 (21%)
		ANK	229..354	CDD:238125	34/134 (25%)
		ANK repeat	234..265	CDD:293786	10/36 (28%)
		ANK repeat	663..694	CDD:293786	8/33 (24%)
		ANK 19	663..692		7/31 (23%)
		Ank_2	669..759	CDD:289560	29/95 (31%)
		ANK repeat	696..727	CDD:293786	13/32 (41%)
		ANK 20	696..725		12/30 (40%)
		ANK repeat	729..760	CDD:293786	7/31 (23%)
		ANK 21	729..758		7/29 (24%)
		Ank_5	749..803	CDD:290568	15/54 (28%)
		ANK 22	762..791		9/28 (32%)
		ANK repeat	762..790	CDD:293786	9/27 (33%)
		ANK 23	795..825		7/29 (24%)
		ZU5	982..1086	CDD:128514
UPA domain. /evidence=ECO:0000250	1273..1407
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1519..1540
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..1987
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2107..2159
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2176..2245
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2299..2322
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2383..2433
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2474..2508
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2588..2751
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2795..2824
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3036..3067
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3131..3272
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3298..3516
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3538..3607
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3635..3718
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3868..3897
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4019..4090
Death_ank3	4088..4171	CDD:176781
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4251..4298
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4323..4377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940