DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and Trpa1

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_808449.1 Gene:Trpa1 / 277328 MGIID:3522699 Length:1125 Species:Mus musculus


Alignment Length:1206 Identity:395/1206 - (32%)
Similarity:629/1206 - (52%) Gaps:164/1206 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LLPKPRSNSSGSTGRNSKYWIFSMIIERSAGPK--------RIEIDGDDADTPLEAILPAEPPAE 84
            |||:.|....|             ::.|..|..        :::|:||                 
Mouse     9 LLPEERKEVQG-------------VVYRGVGEDMDCSKESFKVDIEGD----------------- 43

  Fly    85 VCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNG 149
            :|.|.|                    |:.:..:::..:.:.....|.|||..:|.::..|  .||
Mouse    44 MCRLED--------------------FIKNRRKLSKYEDENLCPLHHAAAEGQVELMELI--ING 86

  Fly   150 D----FNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVM 210
            .    .|..|..||||||.|.|.:..:::.:|||...:..:.|....:|:|:|          |.
Mouse    87 SSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMSPLHIA----------VH 141

  Fly   211 GQYRNVI---------DIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNN---GYYP 263
            |.|..||         :|...||:|.|||......|:.|..:||:.:    ..|.|.:   |.||
Mouse   142 GMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEALQILLEK----GAKLCKSNKWGDYP 202

  Fly   264 IHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKIS 328
            :|:||.:.:.|.||:...:||:.|.:||..|:|.:.:...|||.||..||:..:::||.:||.|.
Mouse   203 VHQAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKASPLHLAVQSGDLDMIKMCLDNGAHID 267

  Fly   329 TQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVA 393
            ..::.....:|.|..|||.||||||.........: ::..|..:.|.||.||:|||.|:..||::
Mouse   268 MMENAKCMALHFAATQGATDIVKLMISSYTGSSDI-VNAVDGNQETLLHRASLFDHHDLAEYLIS 331

  Fly   394 EGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQ 458
            .|||||:.|.|.||||:||.:.:.|..|:||:..||.:.:||...||.||..:.....|.:...:
Mouse   332 VGADINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPE 396

  Fly   459 VANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 523
            ....|   .:|.|:.::|:.||:|||||.|.|...|:.||:.....|:.|:.:.:|||||||.||
Mouse   397 FMQMQ---HIKELVMDEDNDGCTPLHYACRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 458

  Fly   524 RYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAA 588
            |.||.::||.....:.::||.|..||||||::::.||.:||||||.:|||...||.|...|..|:
Mouse   459 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHAS 523

  Fly   589 MSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYA 653
            |.|||:|::::...:....|::|::||||||.|..|....|:::|:|....::.|....|.:..|
Mouse   524 MGGYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIA 588

  Fly   654 IYYKYPEAALAMVTHE--ERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSK 716
            ::.|..|..|..:.::  :...:|....|..:.|..:.::..:|:..:.:.|.|:..:...|..:
Mouse   589 LHNKRKEVVLTTIRNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQ 653

  Fly   717 SFYIKYSFAFLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWN 781
            .::|:|:|.:||||....|....|.:.:..    ||..||.||.|.|:|||.||:.::||.|||.
Mouse   654 DYHIEYNFKYLQCPLSMTKKVAPTQDVVYE----PLTILNVMVQHNRIELLNHPVCREYLLMKWC 714

  Fly   782 SYGKYFHLANLLIYSIFLV-----FVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQN 841
            :||...|:.||..|.:.|:     .|.|...:..|:..:..|.:.|.                  
Mouse   715 AYGFRAHMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINGTSSTH------------------ 761

  Fly   842 PSVASQIRLDSCEERINRTTA--ILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVL 904
                        ||||:...:  |..|.:::.:..:....:|:|||:|||.:|.|:..|.:.||:
Mouse   762 ------------EERIDTLNSFPIKICMILVFLSSIFGYCKEVIQIFQQKRNYFLDYNNALEWVI 814

  Fly   905 YISALVMVTPAFQPDGGINT---IHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLI 966
            |.::::.|.|.|     :|.   :.:...:||:|..|...||:||||:..||::||...|.:||:
Mouse   815 YTTSIIFVLPLF-----LNIPAYMQWQCGAIAIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLL 874

  Fly   967 KVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRD 1031
            :...||..|::||||:||:||: ..|      :||...:||::|||||||::::...::...:|:
Mouse   875 RSTGVFIFLLLAFGLSFYVLLN-FQD------AFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRN 932

  Fly  1032 QLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVW 1096
            :|..|:.:|..|..|.:.:||:|||||||||||||..|:::|.|||:||||.|||.||:|||..:
Mouse   933 ELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWY 997

  Fly  1097 LQRVDKMELIEYPNETK--CKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRK 1159
            |::||:...|.|||..:  ..|.|..:.|.       .:::..:|   .|.|..:..|:.:|:.:
Mouse   998 LRKVDQRSTIVYPNRPRHGRMLRFFHYFLN-------MQETRQEV---PNIDTCLEMEILKQKYR 1052

  Fly  1160 LRDISRMLEQQHHLVRLIVQKMEIKTEADDVDEGIS 1195
            |:|::.:||:||.|::||:|||||.:|.:|.|...|
Mouse  1053 LKDLTSLLEKQHELIKLIIQKMEIISETEDEDNHCS 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 22/96 (23%)
ANK 121..246 CDD:238125 40/137 (29%)
ANK repeat 125..155 CDD:293786 9/33 (27%)
ANK repeat 157..199 CDD:293786 14/41 (34%)
Ank_2 230..330 CDD:289560 35/102 (34%)
ANK repeat 259..298 CDD:293786 16/41 (39%)
ANK 298..425 CDD:238125 51/126 (40%)
ANK repeat 300..330 CDD:293786 12/29 (41%)
Ank_2 305..402 CDD:289560 39/96 (41%)
ANK repeat 336..369 CDD:293786 11/32 (34%)
ANK repeat 374..402 CDD:293786 16/27 (59%)
ANK repeat 404..476 CDD:293786 23/71 (32%)
ANK 473..599 CDD:238125 59/125 (47%)
ANK repeat 478..509 CDD:293786 13/30 (43%)
Ank_2 483..572 CDD:289560 42/88 (48%)
ANK repeat 511..545 CDD:293786 16/33 (48%)
ANK 542..662 CDD:238125 48/119 (40%)
ANK repeat 547..576 CDD:293786 17/28 (61%)
Ank_2 552..643 CDD:289560 36/90 (40%)
ANK repeat 579..611 CDD:293786 9/31 (29%)
ANK repeat 613..638 CDD:293786 11/24 (46%)
Ion_trans 858..1074 CDD:278921 81/220 (37%)
Trpa1NP_808449.1 Ank_2 41..129 CDD:372319 27/126 (21%)
ANK 1 63..94 8/32 (25%)
ANK repeat 67..96 CDD:293786 9/30 (30%)
ANK repeat 98..129 CDD:293786 11/30 (37%)
ANK 2 98..127 11/28 (39%)
Ank_2 101..>373 CDD:393464 101/286 (35%)
ANK repeat 131..163 CDD:293786 9/41 (22%)
ANK 3 131..161 9/39 (23%)
ANK 4 165..194 9/32 (28%)
ANK repeat 165..190 CDD:293786 8/28 (29%)
ANK repeat 198..237 CDD:293786 16/38 (42%)
ANK 5 198..227 11/28 (39%)
ANK 6 239..268 12/28 (43%)
ANK repeat 242..307 CDD:293786 23/65 (35%)
ANK 7 272..301 11/28 (39%)
ANK repeat 309..340 CDD:293786 16/30 (53%)
ANK 8 309..338 15/28 (54%)
ANK repeat 342..373 CDD:293786 13/30 (43%)
ANK 9 342..371 13/28 (46%)
ANK repeat 413..444 CDD:293786 13/30 (43%)
ANK 10 413..442 13/28 (46%)
Ank_2 418..507 CDD:372319 42/88 (48%)
ANK repeat 446..480 CDD:293786 16/33 (48%)
ANK 11 446..475 14/28 (50%)
ANK repeat 482..512 CDD:293786 17/29 (59%)
ANK 12 482..511 17/28 (61%)
Ank_2 487..578 CDD:372319 36/90 (40%)
ANK repeat 514..546 CDD:293786 9/31 (29%)
ANK 13 514..543 8/28 (29%)
ANK 14 548..577 11/28 (39%)
ANK repeat 548..573 CDD:293786 11/24 (46%)
Ion_trans <799..975 CDD:366146 73/187 (39%)
Inositolphosphate binding. /evidence=ECO:0000250|UniProtKB:O75762 1048..1054 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831932
Domainoid 1 1.000 151 1.000 Domainoid score I4347
eggNOG 1 0.900 - - E2759_KOG0510
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7189
Inparanoid 1 1.050 636 1.000 Inparanoid score I833
Isobase 1 0.950 - 0 Normalized mean entropy S4691
OMA 1 1.010 - - QHG46546
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006155
OrthoInspector 1 1.000 - - oto95081
orthoMCL 1 0.900 - - OOG6_104949
Panther 1 1.100 - - LDO PTHR24123
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 1 1.000 - - X5089
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.740

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