DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and Trpa1

DIOPT Version :10

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_808449.1 Gene:Trpa1 / 277328 MGIID:3522699 Length:1125 Species:Mus musculus


Alignment Length:1206 Identity:395/1206 - (32%)
Similarity:629/1206 - (52%) Gaps:164/1206 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LLPKPRSNSSGSTGRNSKYWIFSMIIERSAGPK--------RIEIDGDDADTPLEAILPAEPPAE 84
            |||:.|....|             ::.|..|..        :::|:||                 
Mouse     9 LLPEERKEVQG-------------VVYRGVGEDMDCSKESFKVDIEGD----------------- 43

  Fly    85 VCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNG 149
            :|.|.|                    |:.:..:::..:.:.....|.|||..:|.::..|  .||
Mouse    44 MCRLED--------------------FIKNRRKLSKYEDENLCPLHHAAAEGQVELMELI--ING 86

  Fly   150 D----FNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVM 210
            .    .|..|..||||||.|.|.:..:::.:|||...:..:.|....:|:|:|          |.
Mouse    87 SSCEVLNIMDGYGNTPLHCAAEKNQVESVKFLLSQGANPNLRNRNMMSPLHIA----------VH 141

  Fly   211 GQYRNVI---------DIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNN---GYYP 263
            |.|..||         :|...||:|.|||......|:.|..:||:.:    ..|.|.:   |.||
Mouse   142 GMYNEVIKVLTEHKATNINLEGENGNTALMSTCAKDNSEALQILLEK----GAKLCKSNKWGDYP 202

  Fly   264 IHEAAKNASSKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKIS 328
            :|:||.:.:.|.||:...:||:.|.:||..|:|.:.:...|||.||..||:..:::||.:||.|.
Mouse   203 VHQAAFSGAKKCMELILAYGEKNGYSRETHINFVNHKKASPLHLAVQSGDLDMIKMCLDNGAHID 267

  Fly   329 TQQHDLSTPVHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVA 393
            ..::.....:|.|..|||.||||||.........: ::..|..:.|.||.||:|||.|:..||::
Mouse   268 MMENAKCMALHFAATQGATDIVKLMISSYTGSSDI-VNAVDGNQETLLHRASLFDHHDLAEYLIS 331

  Fly   394 EGADINALDKEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQ 458
            .|||||:.|.|.||||:||.:.:.|..|:||:..||.:.:||...||.||..:.....|.:...:
Mouse   332 VGADINSTDSEGRSPLILATASASWNIVNLLLCKGAKVDIKDHLGRNFLHLTVQQPYGLRNLRPE 396

  Fly   459 VANCQTQAQLKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYG 523
            ....|   .:|.|:.::|:.||:|||||.|.|...|:.||:.....|:.|:.:.:|||||||.||
Mouse   397 FMQMQ---HIKELVMDEDNDGCTPLHYACRQGVPVSVNNLLGFNVSIHSKSKDKKSPLHFAASYG 458

  Fly   524 RYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAA 588
            |.||.::||.....:.::||.|..||||||::::.||.:||||||.:|||...||.|...|..|:
Mouse   459 RINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHAS 523

  Fly   589 MSGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYA 653
            |.|||:|::::...:....|::|::||||||.|..|....|:::|:|....::.|....|.:..|
Mouse   524 MGGYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVAMLLSYNADILLNKKQASFLHIA 588

  Fly   654 IYYKYPEAALAMVTHE--ERANEVMALRSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSK 716
            ::.|..|..|..:.::  :...:|....|..:.|..:.::..:|:..:.:.|.|:..:...|..:
Mouse   589 LHNKRKEVVLTTIRNKRWDECLQVFTHNSPSNRCPIMEMVEYLPECMKVLLDFCMIPSTEDKSCQ 653

  Fly   717 SFYIKYSFAFLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWN 781
            .::|:|:|.:||||....|....|.:.:..    ||..||.||.|.|:|||.||:.::||.|||.
Mouse   654 DYHIEYNFKYLQCPLSMTKKVAPTQDVVYE----PLTILNVMVQHNRIELLNHPVCREYLLMKWC 714

  Fly   782 SYGKYFHLANLLIYSIFLV-----FVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQN 841
            :||...|:.||..|.:.|:     .|.|...:..|:..:..|.:.|.                  
Mouse   715 AYGFRAHMMNLGSYCLGLIPMTLLVVKIQPGMAFNSTGIINGTSSTH------------------ 761

  Fly   842 PSVASQIRLDSCEERINRTTA--ILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVL 904
                        ||||:...:  |..|.:::.:..:....:|:|||:|||.:|.|:..|.:.||:
Mouse   762 ------------EERIDTLNSFPIKICMILVFLSSIFGYCKEVIQIFQQKRNYFLDYNNALEWVI 814

  Fly   905 YISALVMVTPAFQPDGGINT---IHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLI 966
            |.::::.|.|.|     :|.   :.:...:||:|..|...||:||||:..||::||...|.:||:
Mouse   815 YTTSIIFVLPLF-----LNIPAYMQWQCGAIAIFFYWMNFLLYLQRFENCGIFIVMLEVIFKTLL 874

  Fly   967 KVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRD 1031
            :...||..|::||||:||:||: ..|      :||...:||::|||||||::::...::...:|:
Mouse   875 RSTGVFIFLLLAFGLSFYVLLN-FQD------AFSTPLLSLIQTFSMMLGDINYRDAFLEPLFRN 932

  Fly  1032 QLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVW 1096
            :|..|:.:|..|..|.:.:||:|||||||||||||..|:::|.|||:||||.|||.||:|||..:
Mouse   933 ELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTNLEKKLPLWY 997

  Fly  1097 LQRVDKMELIEYPNETK--CKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAELERQRRK 1159
            |::||:...|.|||..:  ..|.|..:.|.       .:::..:|   .|.|..:..|:.:|:.:
Mouse   998 LRKVDQRSTIVYPNRPRHGRMLRFFHYFLN-------MQETRQEV---PNIDTCLEMEILKQKYR 1052

  Fly  1160 LRDISRMLEQQHHLVRLIVQKMEIKTEADDVDEGIS 1195
            |:|::.:||:||.|::||:|||||.:|.:|.|...|
Mouse  1053 LKDLTSLLEKQHELIKLIIQKMEIISETEDEDNHCS 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..183 CDD:463710 22/91 (24%)
ANK repeat 125..155 CDD:293786 9/33 (27%)
ANKYR 140..461 CDD:440430 115/336 (34%)
ANK repeat 157..199 CDD:293786 14/41 (34%)
ANK repeat 259..298 CDD:293786 16/41 (39%)
ANK repeat 300..330 CDD:293786 12/29 (41%)
ANK repeat 336..369 CDD:293786 11/32 (34%)
ANKYR 368..634 CDD:440430 111/265 (42%)
ANK repeat 374..402 CDD:293786 16/27 (59%)
ANK repeat 404..476 CDD:293786 23/71 (32%)
ANK repeat 478..509 CDD:293786 13/30 (43%)
TRPV 481..1093 CDD:454755 220/623 (35%)
ANK repeat 511..545 CDD:293786 16/33 (48%)
ANK repeat 547..576 CDD:293786 17/28 (61%)
ANK repeat 579..611 CDD:293786 9/31 (29%)
ANK repeat 613..638 CDD:293786 11/24 (46%)
Trpa1NP_808449.1 ANKYR 47..337 CDD:440430 100/326 (31%)
ANK 1. /evidence=ECO:0000255 63..94 8/32 (25%)
ANK repeat 67..96 CDD:293786 9/30 (30%)
ANK repeat 98..129 CDD:293786 11/30 (37%)
ANK 2. /evidence=ECO:0000255 98..127 11/28 (39%)
ANK repeat 131..163 CDD:293786 9/41 (22%)
ANK 3. /evidence=ECO:0000255 131..161 9/39 (23%)
ANK 4. /evidence=ECO:0000255 165..194 9/32 (28%)
ANK repeat 165..190 CDD:293786 8/28 (29%)
Ank_4 166..219 CDD:372654 19/56 (34%)
ANK repeat 198..237 CDD:293786 16/38 (42%)
ANK 5. /evidence=ECO:0000255 198..227 11/28 (39%)
ANK 6. /evidence=ECO:0000255 239..268 12/28 (43%)
ANKYR 241..552 CDD:440430 127/314 (40%)
ANK repeat 242..307 CDD:293786 23/65 (35%)
ANK 7. /evidence=ECO:0000255 272..301 11/28 (39%)
ANK repeat 309..340 CDD:293786 16/30 (53%)
ANK 8. /evidence=ECO:0000255 309..338 15/28 (54%)
ANK repeat 342..373 CDD:293786 13/30 (43%)
ANK 9. /evidence=ECO:0000255 342..371 13/28 (46%)
ANK repeat 413..444 CDD:293786 13/30 (43%)
ANK 10. /evidence=ECO:0000255 413..442 13/28 (46%)
ANK repeat 446..480 CDD:293786 16/33 (48%)
ANK 11. /evidence=ECO:0000255 446..475 14/28 (50%)
ANK repeat 482..512 CDD:293786 17/29 (59%)
ANK 12. /evidence=ECO:0000255 482..511 17/28 (61%)
ANK repeat 514..546 CDD:293786 9/31 (29%)
ANK 13. /evidence=ECO:0000255 514..543 8/28 (29%)
ANK 14. /evidence=ECO:0000255 548..577 11/28 (39%)
Ank 548..575 CDD:459634 11/26 (42%)
ANK repeat 548..573 CDD:293786 11/24 (46%)
Ion_trans 762..975 CDD:459842 85/224 (38%)

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