DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and trpa-1

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_502249.3 Gene:trpa-1 / 178118 WormBaseID:WBGene00007801 Length:1211 Species:Caenorhabditis elegans


Alignment Length:1266 Identity:317/1266 - (25%)
Similarity:546/1266 - (43%) Gaps:215/1266 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 RIEIDGDDADTPLEAILPAEPPAEVCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKG 125
            |.|.||..|.....|.|.|...|:  .||..   |.::|..||::..:...:.....:..:|...
 Worm    25 RSEKDGRQASIFRVAELDARTEAD--NLRSI---IHQSAREGNVNALQEALLKAPLAVNAQDGDF 84

  Fly   126 RTAAHQAAARNRVNILRYIRDQNGDFNAKDNAGNTPLHIA-------------VESDAYDA---- 173
            .|..|.||.....:.::.:..:|...|.|:..|:||||||             ::.|..|:    
 Worm    85 MTPLHYAARYGNYDAVKLLLSKNALPNTKNREGDTPLHIASKYIYGYSDICSIIDEDQADSARKY 149

  Fly   174 -------LDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVIDIQQGGEHGRTALH 231
                   ::.|:|...:...:|:.:..|:|.|...:...:|..:.:.:..:|.:.  ::..|.|.
 Worm   150 NTATKKIINALVSENAEIDPVNKYQLTPLHYAAMKSNFSALHALIKLKADVDAED--DNKMTPLL 212

  Fly   232 LAAIYDHEECARILI-TEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQWGEQRGCTREEMIS 295
            ||.::..:|..:.|| ...:...|....|..:  |..|.....:.:|:..........   :.::
 Worm   213 LACVHGSQEIIQELIKANSNVTKRDQRLNTVF--HIVALRGEPEYLEMMMDHDPVEAI---KALN 272

  Fly   296 FYDSEGNVPLHSAVHGGDIKAVELCL----KSGAKISTQQHDLSTPVHLACAQGAIDIVKLMFEM 356
            .:::|...||..||.|...:.::..|    |:..|...::.:|   :|.|..:|.::::|.:.|.
 Worm   273 LFNNEKKTPLRMAVEGNHPETLKKILQMEKKNSCKWMDREKEL---IHFAAEKGFLEVLKALVEA 334

  Fly   357 QPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGAD-INALDKEHRSPLLLAASRSGWKT 420
            ...:..|     :..|..|||.|:..:..::||||:.|..| |:.:|::..:||::|.:....|.
 Worm   335 GGNKNEL-----NEVKAVPLHVAAQMNQLEVVSYLIEEEKDNIDVVDEQGLTPLMMAVTHDSKKC 394

  Fly   421 VHLLIRLGACISVKDAAAR---------NVL---HFVIMNGGRLTDFAEQVA-NCQTQAQLKL-- 470
            |..||...|.:::.|...|         |.|   .:::.:..:.....|:.| ...|:..|::  
 Worm   395 VEYLIAKKANLTITDKDERTPVFIGAKFNALSSVEYILDHLRKKNKETERSALKSPTRNTLRIVS 459

  Fly   471 ------LLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVR 529
                  ::|..|....:|:|..:.:|::..::.|.:.||.|...|.:.|:.||.||..|:...||
 Worm   460 EDVRRTMVNMVDRDQNTPMHIVASNGYLEMMQLLQKHGASITQVNEDEETALHRAAIGGQTGAVR 524

  Fly   530 QLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRN-----PLQLAAM 589
            |||:.:....::  .|..|.:.||::::.||....::||:.||    |...:|     |||:|..
 Worm   525 QLLEWDIRLLLM--KDEMGNSALHLAARSGHDATTKVLLDNGA----DKEAKNSYQKTPLQVAVD 583

  Fly   590 SGYTETIELLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLD------MS 648
            ||..||.:.|.:..:.:  :...|..|.||.|........:...::.|.     .:|      .:
 Worm   584 SGKLETCQRLVAKGAQI--ESSSDTKTVLHTAAFYGNESIVRYFIAEGV-----TIDRRDEEGKT 641

  Fly   649 AIDYAIYYKYPEAALAMVTHEERAN-----EVMALRSDKH----------PCVTLALIASMPKVF 698
            |.|.|....:.:.|.|.:..::..|     :|:.|  |||          |..|  |:...|::.
 Worm   642 AFDIACENDHKDVARAFLETDQWKNLMIPCDVIPL--DKHRNPVNMKRRTPFRT--LLTKFPELA 702

  Fly   699 EAVQDKCITKANCKKDSKSFYIKYSFAFLQCPFMFAKI-DEKTGESI------------------ 744
            ..|.|.||.|:..:.||.. .:.|:|.||...:|...: |:.|||.:                  
 Worm   703 SFVMDNCIEKSKEETDSTQ-SVAYNFEFLDDTYMMRCVSDDGTGEQLIGCKSAYDEDFKLEKDAQ 766

  Fly   745 TTAS---------PIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLANLLIYSIFLV 800
            :.||         |:.|     |....::.||.||||:..|:.|||..|:..:...|.:|.:|:|
 Worm   767 SYASNYDRVYKYHPLKL-----MADAEKLHLLNHPLSKALLKYKWNRLGRPMYYFALFMYLVFIV 826

  Fly   801 FVTIYSSLMMNNIELKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASQIRLDSCE--ERINRTTAI 863
            .:|.|.             ..|.:.|          |:....|.......|..|  .:||.|...
 Worm   827 SLTQYV-------------RHTKAPY----------NVWNEESYYDSEYFDENETCPQINTTKPD 868

  Fly   864 LFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYISALVMV---TPAFQPDGGINTI 925
            :...::|....:...:.|..|::|:|..|::...|.|...:|.:||:.|   :......|.....
 Worm   869 VVWKIIIQTLAVCQILVECFQLFQRKFAYLVNWENWIDCFIYSTALITVYDFSECSATSGVRQNW 933

  Fly   926 HYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKI 990
            .:..|::.:|..|..||..:::..:.||:||||::|::|..:...||.:.||||..:||::|.  
 Worm   934 QWILAALCIFFGWINLLFMIRKMPRFGIFVVMFVDIVKTFFRFFPVFVLFIIAFSSSFYVILQ-- 996

  Fly   991 IDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTY--VNTYYRDQLKVPMTSFLILSVFM---ILM 1050
                 |...||.|.||.|:|..||:||.:|.|.:  ..|.:.:::..|..:.:..::|.   |:|
 Worm   997 -----NRPEFSTIFMSPLKTTVMMIGEFEFTGIFHGDETTHAEKMFGPAHTAVACALFFFFCIIM 1056

  Fly  1051 PILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQRVDKMELIEY---PNET 1112
            .|||||||:||||.||:.|:..|:||||||||.|..::|..| |.::||..|.....|   |...
 Worm  1057 TILLMNLLVGLAVDDIKGVQEKAELKRLAMQVDLVLQIEASL-HFFIQRTKKYATCRYATFPYGK 1120

  Fly  1113 KCKLGFCDFILRKWFSNPFTEDSSMDVISFDNNDDYINAE----------LERQRRKLRDISR-- 1165
            ..|.||..     |:|| |.....:.|.:....|:....|          |:.|..||::|..  
 Worm  1121 LHKTGFAG-----WWSN-FRRRFGLSVSTDPEIDEMYEREAEFTSEMTQKLQNQAAKLKNIQENI 1179

  Fly  1166 --MLEQQHHLVRLIVQ---KMEIKTEADDVD 1191
              |.|:|..|..:|.:   .:.|..|.::.|
 Worm  1180 DVMYEKQVRLEAIIAKLATGLNINIELEEKD 1210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 23/116 (20%)
ANK 121..246 CDD:238125 30/148 (20%)
ANK repeat 125..155 CDD:293786 6/29 (21%)
ANK repeat 157..199 CDD:293786 14/65 (22%)
Ank_2 230..330 CDD:289560 20/104 (19%)
ANK repeat 259..298 CDD:293786 4/38 (11%)
ANK 298..425 CDD:238125 34/131 (26%)
ANK repeat 300..330 CDD:293786 9/33 (27%)
Ank_2 305..402 CDD:289560 26/101 (26%)
ANK repeat 336..369 CDD:293786 6/32 (19%)
ANK repeat 374..402 CDD:293786 11/28 (39%)
ANK repeat 404..476 CDD:293786 17/92 (18%)
ANK 473..599 CDD:238125 41/130 (32%)
ANK repeat 478..509 CDD:293786 7/30 (23%)
Ank_2 483..572 CDD:289560 26/88 (30%)
ANK repeat 511..545 CDD:293786 11/33 (33%)
ANK 542..662 CDD:238125 31/130 (24%)
ANK repeat 547..576 CDD:293786 9/28 (32%)
Ank_2 552..643 CDD:289560 25/95 (26%)
ANK repeat 579..611 CDD:293786 10/36 (28%)
ANK repeat 613..638 CDD:293786 5/24 (21%)
Ion_trans 858..1074 CDD:278921 70/223 (31%)
trpa-1NP_502249.3 Ank_4 51..104 CDD:290365 10/55 (18%)
ANK repeat 51..81 CDD:293786 5/32 (16%)
ANK 78..227 CDD:238125 30/150 (20%)
ANK repeat 86..114 CDD:293786 6/27 (22%)
Ank_2 88..204 CDD:289560 23/115 (20%)
ANK repeat 116..171 CDD:293786 11/54 (20%)
ANK 168..298 CDD:238125 24/136 (18%)
ANK repeat 173..204 CDD:293786 5/30 (17%)
ANK repeat 206..237 CDD:293786 7/30 (23%)
Ank_4 208..258 CDD:290365 11/51 (22%)
Ank_2 244..342 CDD:289560 19/110 (17%)
ANK repeat 280..310 CDD:293786 8/29 (28%)
Ank_2 316..409 CDD:289560 27/97 (28%)
ANK repeat 316..342 CDD:293786 6/30 (20%)
ANK 339..493 CDD:238125 35/158 (22%)
ANK repeat 344..376 CDD:293786 12/31 (39%)
ANK repeat 378..409 CDD:293786 8/30 (27%)
Ank_2 383..504 CDD:289560 24/120 (20%)
ANK 468..594 CDD:238125 41/131 (31%)
ANK repeat 473..504 CDD:293786 7/30 (23%)
Ank_2 479..571 CDD:289560 29/97 (30%)
ANK repeat 506..538 CDD:293786 11/33 (33%)
ANK 536..659 CDD:238125 33/135 (24%)
ANK repeat 540..571 CDD:293786 10/34 (29%)
Ank_2 545..636 CDD:289560 26/101 (26%)
ANK repeat 573..601 CDD:293786 9/29 (31%)
ANK repeat 605..636 CDD:293786 7/35 (20%)
Ion_trans 857..1080 CDD:278921 72/229 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I3728
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7189
Inparanoid 1 1.050 289 1.000 Inparanoid score I1699
Isobase 1 0.950 - 0 Normalized mean entropy S4691
OMA 1 1.010 - - QHG46546
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006155
OrthoInspector 1 1.000 - - oto19665
orthoMCL 1 0.900 - - OOG6_104949
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.810

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