DRSC/TRiP Functional Genomics Resources

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Protein Alignment TrpA1 and unc-44

DIOPT Version :9

Sequence 1:NP_001261600.1 Gene:TrpA1 / 39015 FlyBaseID:FBgn0035934 Length:1232 Species:Drosophila melanogaster
Sequence 2:NP_001367345.1 Gene:unc-44 / 177366 WormBaseID:WBGene00006780 Length:6994 Species:Caenorhabditis elegans


Alignment Length:1405 Identity:283/1405 - (20%)
Similarity:457/1405 - (32%) Gaps:454/1405 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 SPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNGDFNAKD 155
            :|..|  ||..|: ::..:|.:...:.:..:.....:..|.|....|.|:...:..:....:::.
 Worm   229 TPLHI--AAHYGH-ENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSRT 290

  Fly   156 NAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATELNKVKSLRVMGQYRNVID-- 218
            ....||||.|..|.....:|.|:..........:...||:|:|.:.:.|.:.|.:..:|..:|  
 Worm   291 KDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDV 355

  Fly   219 -IQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNNGYYPIHEAAKNASSKTMEVFFQW 282
             :..     .|.||:||...|...|::|: :..|.|.....||:.|:|.|.|....|.:|:..::
 Worm   356 TVDY-----LTPLHVAAHCGHVRVAKLLL-DRSADPNSRALNGFTPLHIACKKNRIKVVELLLKY 414

  Fly   283 ------GEQRGCTREEMISFYDS-------------------EGNVPLHSAVHGGDIKAVELCLK 322
                  ..:.|.|...:.:|..:                   .|..|||.|........|.:.::
 Worm   415 RAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIR 479

  Fly   323 SGAKISTQQHDLSTPVHLACAQGAIDIVKLMFE------------MQPM---------------- 359
            :|||:..|..:|.||:|:|...|..|||.|:.:            ..|:                
 Worm   480 NGAKVDAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILL 544

  Fly   360 ----EKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALDKEHRSPLLLAASRSGWKT 420
                :|.|...    :..||||.||.:.:.::|..|:..|..::...|...:||.:||..:..|.
 Worm   545 DHNADKTLLTK----KGFTPLHLASKYGNLEVVRLLLERGTPVDIEGKNQVTPLHVAAHYNNDKV 605

  Fly   421 VHLLIRLGACISVKDAAARN---VLHFVIMNGGRLTDFAEQVANCQTQAQLKLLLNEKDSMGCSP 482
            ..||:..||  |.| |||:|   .||.....        .|:....|..|.|...|.|...|.:|
 Worm   606 AMLLLENGA--SAK-AAAKNGYTPLHIAAKK--------NQMEIASTLLQFKADPNAKSRAGFTP 659

  Fly   483 LHYASRDGH--IRSL--EN-----------------------------LIRLGACINLKNNNNES 514
            ||.::::||  |..|  ||                             |...||.||.|.|...:
 Worm   660 LHLSAQEGHKEISGLLIENGSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYT 724

  Fly   515 PLHFAARYGRYNTVRQLLDSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLH-RDH 578
            |||.|..:|:.|.|:.|:  |.|: .:.|...|..||||.::||||...|:.||..||..: :..
 Worm   725 PLHVACHFGQLNMVKFLV--ENGA-DVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTA 786

  Fly   579 TGRNPLQLAAMSGYTETIELLHSV------------------------HSHLLDQVDKDGNTALH 619
            ||:.||.:|...||...:|.|.:|                        :..:..:.:.:|..|.|
 Worm   787 TGQTPLSIAQRLGYVSVVETLRTVTETTVITETTTVDERYKPQNPEAMNETMFSESEDEGQAAEH 851

  Fly   620 LATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAALAMVTHEERANEVMALRSDKHP 684
            .|...::       ......|...:.|.:.:                 |.....|.:..||.:  
 Worm   852 EAVAAHE-------KDFSDNLTQGLQDSTGV-----------------HMIHTGEQLLQRSQE-- 890

  Fly   685 CVTLALIASMPKV----------FEAVQDKCITKANCKKDSKSFYI-----KYSFAFLQCPFMFA 734
               |....::||:          |..:.....:......:|:||.|     ..|..|.|.|...|
 Worm   891 ---LENGGAIPKINSGGMSPEKEFAKIAPVATSSPIATSNSQSFGIAPRAGSISGQFQQQPLHGA 952

  Fly   735 KIDEKTGESITTASPIPLPALN------TMVTHG------------------------------- 762
            ..::...|.:..|...|:.|.|      .|:.:|                               
 Worm   953 GPEDNLEELVRRAQNHPINAGNYDNGGVAMLENGHADNVPIGHHVTQPSKLQHRTFLISFLVDAR 1017

  Fly   763 --------------------------------RVELLAHP--------LSQKYLQMKWNSYGKYF 787
                                            |.:.||||        |:.:.|:|.        
 Worm  1018 GGAMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLAHPPPLSEGEELASRILEMA-------- 1074

  Fly   788 HLANLLIYSIFLVFVTIYSSLMMNNIE---LKAGDNKTMSQYCNMGWEQLTMNLSQNPSVASQIR 849
             .|........::.|..::||.....|   |::.|.:        .|::..:..::         
 Worm  1075 -PAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQ--------HWKEHQLEATE--------- 1121

  Fly   850 LDSCEERIN-----------------RTTAIL------FCAVVIVVYILLNSMRELIQIYQQKLH 891
             |:.:|.:|                 |.|.||      :.|||..|              :|::|
 Worm  1122 -DAVQEVLNESFDAEDLAQLDDLQTPRITRILTSDFPMYFAVVTRV--------------RQEVH 1171

  Fly   892 YILETVNLISWVLYISALVMVTPAFQPDGGI-NTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYV 955
            .:.....:|     ||::|....|..|||.: .||..|                           
 Worm  1172 CVGPEGGVI-----ISSVVPRVQAIFPDGSLTKTIKVS--------------------------- 1204

  Fly   956 VMFLEILQTLIKVLMVFSILIIAFGLAFYILLSKIIDPQPNHLSFSN-----IPMSLLRTFSMML 1015
            |....:.|.::..|.           ...:.:|.|:..:|....|..     ||:.......|: 
 Worm  1205 VQAQPVPQEMVTRLH-----------GNRVAVSPIVTVEPRRRKFHKPITLCIPLPQSNNRGML- 1257

  Fly  1016 GELDFVGTYVNTYYRDQLKVPMTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAM 1080
                      ..|...|.:.|.|..|:.|:            ..|.|....|.:....||.....
 Worm  1258 ----------TQYSGQQGQEPPTLRLLCSI------------TGGSAPAQWEDITGTTQLTFTGD 1300

  Fly  1081 QVVLHTELERKLPHVWL-------------QRVDKMELIEYPNETKCKLGFCDFILRKWFSNPFT 1132
            :|...|.:..:.   ||             |.|.. |.|..|...|    |..|..|     .|.
 Worm  1301 EVSFTTTVSARF---WLMDCQTPRDAARMAQEVYN-EAISIPYMAK----FAVFARR-----TFP 1352

  Fly  1133 EDSSMDVISFDNNDDYINAELERQRR-----KLRDISRMLEQQHHLVRLIVQKMEIKTEADDVDE 1192
            .:..:.|  |...||..:..||:|..     |.||: .:|:.:|..:......:.|....|.:..
 Worm  1353 VEGQLRV--FCMTDDKEDKTLEKQEHFKLIAKSRDV-EVLKGKHQFLEFSGNLVPITKSGDQLSL 1414

  Fly  1193 GISP---NELRSVVGLRSAGGNR---------WNSPRVRN 1220
            ...|   |.|..:|..||...|.         ...|::|:
 Worm  1415 FFLPFQENRLAFMVKTRSNDDNEAATEGRIGFMAEPKIRS 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpA1NP_001261600.1 Ank_2 95..188 CDD:289560 17/92 (18%)
ANK 121..246 CDD:238125 27/127 (21%)
ANK repeat 125..155 CDD:293786 4/29 (14%)
ANK repeat 157..199 CDD:293786 11/41 (27%)
Ank_2 230..330 CDD:289560 29/124 (23%)
ANK repeat 259..298 CDD:293786 11/44 (25%)
ANK 298..425 CDD:238125 39/177 (22%)
ANK repeat 300..330 CDD:293786 9/29 (31%)
Ank_2 305..402 CDD:289560 30/128 (23%)
ANK repeat 336..369 CDD:293786 12/64 (19%)
ANK repeat 374..402 CDD:293786 9/27 (33%)
ANK repeat 404..476 CDD:293786 22/74 (30%)
ANK 473..599 CDD:238125 52/159 (33%)
ANK repeat 478..509 CDD:293786 15/63 (24%)
Ank_2 483..572 CDD:289560 38/121 (31%)
ANK repeat 511..545 CDD:293786 11/33 (33%)
ANK 542..662 CDD:238125 31/144 (22%)
ANK repeat 547..576 CDD:293786 14/29 (48%)
Ank_2 552..643 CDD:289560 26/115 (23%)
ANK repeat 579..611 CDD:293786 10/55 (18%)
ANK repeat 613..638 CDD:293786 4/24 (17%)
Ion_trans 858..1074 CDD:278921 41/244 (17%)
unc-44NP_001367345.1 ANK repeat 32..63 CDD:293786
PHA03095 37..>387 CDD:222980 36/166 (22%)
ANK repeat 65..96 CDD:293786
ANK repeat 98..129 CDD:293786
ANK repeat 131..156 CDD:293786
ANK repeat 197..224 CDD:293786
ANK repeat 226..257 CDD:293786 6/30 (20%)
PHA02876 <242..>648 CDD:165207 96/426 (23%)
ANK repeat 259..290 CDD:293786 4/30 (13%)
ANK repeat 292..322 CDD:293786 8/29 (28%)
ANK repeat 325..356 CDD:293786 8/30 (27%)
ANK repeat 358..389 CDD:293786 10/36 (28%)
ANK repeat 391..422 CDD:293786 8/30 (27%)
ANK repeat 424..455 CDD:293786 3/30 (10%)
ANK repeat 457..488 CDD:293786 9/30 (30%)
ANK repeat 490..519 CDD:293786 10/28 (36%)
ANK repeat 523..552 CDD:293786 2/28 (7%)
Ank_2 555..>780 CDD:423045 74/242 (31%)
ANK repeat 556..586 CDD:293786 9/29 (31%)
ANK repeat 589..620 CDD:293786 12/33 (36%)
ANK repeat 622..652 CDD:293786 8/37 (22%)
ANK repeat 655..685 CDD:293786 10/29 (34%)
ANK repeat 688..719 CDD:293786 5/30 (17%)
ANK repeat 721..752 CDD:293786 11/33 (33%)
ANK repeat 754..784 CDD:293786 14/29 (48%)
Ank_4 756..807 CDD:372654 21/50 (42%)
ZU5 1008..1110 CDD:128514 15/110 (14%)
UPA_2 1337..1472 CDD:375346 29/130 (22%)
Death_ank 1503..1580 CDD:260029
PTZ00449 <1770..2112 CDD:185628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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