DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TrpA1 and trpa1

DIOPT Version :9

Sequence 1:	NP_001261600.1	Gene:	TrpA1 / 39015	FlyBaseID:	FBgn0035934	Length:	1232	Species:	Drosophila melanogaster
Sequence 2:	NP_001121434.1	Gene:	trpa1 / 100158526	XenbaseID:	XB-GENE-1004945	Length:	1144	Species:	Xenopus tropicalis

Alignment Length:	1136	Identity:	417/1136 - (36%)
Similarity:	646/1136 - (56%)	Gaps:	84/1136 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VCLLRDSPFRILRAAESGNLDDFKRLFMADNSRIALKDAKGRTAAHQAAARNRVNILRYIRDQNG 149
            ||.|.|:|..|.:....||:...:...:.:...:|.:|....|..|.||....::::..|.:::.
Frog    29 VCSLDDNPLLIFKLIAEGNVCRVRNFVLKNPGSLAARDDSEATPLHHAAKLGNIDLMLMIVNESA 93

  Fly   150 D--FNAKDNAGNTPLHIAVESDAYDALDYLLSIPVDTGVLNEKKQAPVHLATEL--NKVKSLRVM 210
            :  .||.|:.||||||.||:.:..|.|..||....|..:.|..:.:|:|||.:|  |.:....::
Frog    94 EEGINALDSRGNTPLHWAVQKNKLDCLKVLLCRGADPNIQNCYRLSPLHLAIQLFHNSIAEALIL 158

  Fly   211 GQYRNVIDIQQGGEHGRTALHLAAIYDHEECARILITEFDACPRKPCNN---GYYPIHEAAKNAS 272
               .:..||...|:.|.|.:..|...|:.|...:|:..    ..|.|..   |.||||..|...|
Frog   159 ---HSTTDINLEGDLGNTPVMQACCKDNHEALNLLLGR----GAKLCKQNKLGCYPIHMTAFMGS 216

  Fly   273 SKTMEVFFQWGEQRGCTREEMISFYDSEGNVPLHSAVHGGDIKAVELCLKSGAKISTQQHDLSTP 337
            .|.|::..:.||:.|.|.:..|:|.::|.:.|||.||..|:|..|:.|:..||||..:|.|.:|.
Frog   217 LKCMDIILKKGEEMGYTIDHHINFTNNEKSSPLHLAVQNGNIDVVKACISYGAKIDLRQSDNATA 281

  Fly   338 VHLACAQGAIDIVKLMFEMQPMEKRLCLSCTDVQKMTPLHCASMFDHPDIVSYLVAEGADINALD 402
            :|.|..|||.:|||.|......:.:: :...|....||||.:.:|||.::..||::|||:|::.|
Frog   282 LHFAATQGATEIVKFMVSSYSDDNKI-VDLPDGNDETPLHKSVLFDHVELAEYLISEGANIDSED 345

  Fly   403 KEHRSPLLLAASRSGWKTVHLLIRLGACISVKDAAARNVLHFVIMNGGRLTDFAEQVANCQTQAQ 467
            ||.|:|||||.|.|.||:|:||:..||.:.:||...||.||.:::..|.|.:...:....:   .
Frog   346 KESRTPLLLATSCSAWKSVNLLLSKGADVKLKDHYGRNFLHLMVLQPGGLKNLNSEFLQME---N 407

  Fly   468 LKLLLNEKDSMGCSPLHYASRDGHIRSLENLIRLGACINLKNNNNESPLHFAARYGRYNTVRQLL 532
            :|.|::::|..||:|||||.|.|...|:.||:.|...:..|:.|..|||||||.|||:||.::||
Frog   408 IKKLVSDEDCEGCTPLHYACRHGVPNSVNNLLGLNMSLYSKSKNKRSPLHFAACYGRFNTCQRLL 472

  Fly   533 DSEKGSFIINESDGAGMTPLHISSQQGHTRVVQLLLNRGALLHRDHTGRNPLQLAAMSGYTETIE 597
            .......::|:.|..||||||::::.||.::|.|||.|||||..||.|...|..||:||||.||:
Frog   473 RFMSDGRLLNDGDEKGMTPLHLAAENGHEKIVFLLLKRGALLLSDHRGWTALHYAALSGYTRTIK 537

  Fly   598 LLHSVHSHLLDQVDKDGNTALHLATMENKPHAISVLMSMGCKLVYNVLDMSAIDYAIYYKYPEAA 662
            .|......|:|:.||:.|||:|||..|....|:|:|:..|..::.|....|.|..||.:...:..
Frog   538 TLLETSIGLIDKTDKEQNTAMHLAGREGHAKAVSLLLENGASILLNANGASYIHEAIRFGKKDTV 602

  Fly   663 LAMVTHEERANEVMAL--RSDKHPCVTLALIASMPKVFEAVQDKCITKANCKKDSKSFYIKYSFA 725
            |..: ..||..|::..  .:..:.|..|.:|..:|:.|:.:.|:|:|::...|.|..|:::|:|.
Frog   603 LVSI-QSERWEEILQTFSHTSSYKCAILEMIYHLPESFKTLLDRCMTESIGDKKSPDFHVEYNFT 666

  Fly   726 FLQCPFMFAKIDEKTGESITTASPIPLPALNTMVTHGRVELLAHPLSQKYLQMKWNSYGKYFHLA 790
            :||||..|.|..::.    ......||..||.||.|.|::||:||:.::||.|||.:||...||.
Frog   667 YLQCPLSFRKAHKRE----NNVHYEPLTTLNAMVQHQRIDLLSHPVCKEYLLMKWMAYGFKAHLL 727

  Fly   791 NLLIYSIFLVFVTIYSSLMMNNI------------ELKAGD--NKTMSQYCNMGWEQLTMNLSQN 841
            ||.|||:.|:.:|:   |::|.:            .||..|  |.:|.|.|        .|:|:
Frog   728 NLAIYSLGLIPLTL---LIINAVRPESLAIIEECEHLKRTDFYNSSMKQEC--------ANVSR- 780

  Fly   842 PSVASQIRLDSCEERINRTTAILFCAVVIVVYILLNSMRELIQIYQQKLHYILETVNLISWVLYI 906
                   :||..:.:..:.|.:  |..::....|...::|.:|:.||||.||.:..|:|.|.:||
Frog   781 -------KLDLLQLKDTQYTRV--CMGLVFCMSLFGIVKEAVQLCQQKLAYIGDGSNIIDWSIYI 836

  Fly   907 SALVMVTPAFQPDGGINTIHYSAASIAVFLSWFRLLLFLQRFDQVGIYVVMFLEILQTLIKVLMV 971
            |:::.|:........::.:.:...:||||.||...|::||||:..|||:|||.|||:||::::.:
Frog   837 SSIIFVSSLCHSPIVVSGLQWQFGAIAVFASWVNFLIYLQRFESYGIYIVMFWEILRTLLRIVFL 901

  Fly   972 FSILIIAFGLAFYILLSKIIDPQPNHLSFSNIPMSLLRTFSMMLGELDFVGTYVNTYYRDQLKVP 1036
            |..||:||||:||:.|.    ||   ::||....:|:::|:||||::::...::.....||::.|
Frog   902 FFFLILAFGLSFYVFLY----PQ---VTFSRPYFALMQSFTMMLGDINYEEGFLKPLLDDQIEYP 959

  Fly  1037 MTSFLILSVFMILMPILLMNLLIGLAVGDIESVRRNAQLKRLAMQVVLHTELERKLPHVWLQRVD 1101
            ..:|:.|.:|.:|:||||||||||||||||..|:|||.|||:||||.|||.||:|||..:|:|||
Frog   960 FFTFIHLIMFTLLIPILLMNLLIGLAVGDIAEVQRNACLKRIAMQVSLHTSLEKKLPFWFLKRVD 1024

  Fly  1102 KMELIEYPNETKCKLGFCDFILRKW----FSNPFTEDSSMDVISFD--NNDDYINAELERQRRKL 1160
            |:.:..|||..           |.|    .||.|...||.|.:..:  .||:.:..||.:|:.:|
Frog  1025 KISITVYPNRP-----------RIWGITFTSNFFHYFSSCDDVKAEIPINDETMELELWKQKNRL 1078

  Fly  1161 RDISRMLEQQHHLVRLIVQKMEIKTEADDVD 1191
            :|::.|:::|:.|::||:|||||.:||:|.|
Frog  1079 KDLTTMMQKQNDLIKLIIQKMEIVSEAEDED 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TrpA1	NP_001261600.1	Ank_2	95..188	CDD:289560	26/94 (28%)
		ANK	121..246	CDD:238125	37/128 (29%)
		ANK repeat	125..155	CDD:293786	7/31 (23%)
		ANK repeat	157..199	CDD:293786	17/41 (41%)
		Ank_2	230..330	CDD:289560	35/102 (34%)
		ANK repeat	259..298	CDD:293786	15/41 (37%)
		ANK	298..425	CDD:238125	55/126 (44%)
		ANK repeat	300..330	CDD:293786	14/29 (48%)
		Ank_2	305..402	CDD:289560	38/96 (40%)
		ANK repeat	336..369	CDD:293786	10/32 (31%)
		ANK repeat	374..402	CDD:293786	13/27 (48%)
		ANK repeat	404..476	CDD:293786	26/71 (37%)
		ANK	473..599	CDD:238125	61/125 (49%)
		ANK repeat	478..509	CDD:293786	13/30 (43%)
		Ank_2	483..572	CDD:289560	41/88 (47%)
		ANK repeat	511..545	CDD:293786	16/33 (48%)
		ANK	542..662	CDD:238125	52/119 (44%)
		ANK repeat	547..576	CDD:293786	17/28 (61%)
		Ank_2	552..643	CDD:289560	41/90 (46%)
		ANK repeat	579..611	CDD:293786	13/31 (42%)
		ANK repeat	613..638	CDD:293786	10/24 (42%)
		Ion_trans	858..1074	CDD:278921	86/215 (40%)
trpa1	NP_001121434.1	Ank_2	43..134	CDD:289560	25/90 (28%)
		ANK repeat	68..101	CDD:293786	7/32 (22%)
		ANK	98..224	CDD:238125	43/132 (33%)
		ANK repeat	103..134	CDD:293786	13/30 (43%)
		Ank_2	108..201	CDD:289560	27/99 (27%)
		ANK repeat	136..168	CDD:293786	8/34 (24%)
		ANK repeat	170..201	CDD:293786	8/34 (24%)
		ANK repeat	203..242	CDD:293786	15/38 (39%)
		ANK	239..368	CDD:238125	56/129 (43%)
		ANK repeat	247..275	CDD:293786	13/27 (48%)
		Ank_2	249..345	CDD:289560	38/96 (40%)
		ANK repeat	277..312	CDD:293786	11/35 (31%)
		ANK repeat	314..345	CDD:293786	13/30 (43%)
		Ank_5	334..387	CDD:290568	28/52 (54%)
		ANK repeat	347..378	CDD:293786	16/30 (53%)
		Ank_4	421..472	CDD:290365	25/50 (50%)
		ANK	447..574	CDD:238125	61/126 (48%)
		ANK repeat	451..485	CDD:293786	16/33 (48%)
		ANK repeat	490..517	CDD:293786	15/26 (58%)
		Ank_2	492..583	CDD:289560	41/90 (46%)
		ANK repeat	519..551	CDD:293786	13/31 (42%)
		ANK repeat	553..578	CDD:293786	10/24 (42%)
		Ion_trans	820..996	CDD:278921	77/182 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3897
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7189
Inparanoid	1	1.050	672	1.000	Inparanoid score	I734
OMA	1	1.010	-	-		QHG46546
OrthoDB	1	1.010	-	-		D180347at33208
OrthoFinder	1	1.000	-	-		FOG0006155
OrthoInspector	1	1.000	-	-		oto105267
Panther	1	1.100	-	-	LDO	PTHR24123
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080